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IL-1β-mediated adaptive reprogramming of endogenous human cardiac fibroblasts to cells with immune features during fibrotic remodeling
The source and roles of fibroblasts and T-cells during maladaptive remodeling and myocardial fibrosis in the setting of pulmonary arterial...
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Antigen presentation by cardiac fibroblasts promotes cardiac dysfunction
Heart failure (HF) is a leading cause of morbidity and mortality. Studies in animal models and individuals with HF revealed a prominent role for CD4 + ...
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Subpopulations of fibroblasts derived from human iPS cells
Organ fibrosis causes collagen fiber overgrowth and impairs organ function. Cardiac fibrosis after myocardial infarction impairs cardiac function...
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Stem cell antigen-1+cell-derived fibroblasts are crucial for cardiac fibrosis during heart failure
AimsMesenchymal stem cells (MSCs) present in the heart cannot differentiate into cardiomyocytes, but may play a role in pathological conditions....
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IPSC derived cardiac fibroblasts of DMD patients show compromised actin microfilaments, metabolic shift and pro-fibrotic phenotype
Duchenne muscular dystrophy (DMD) is a severe form of muscular dystrophy caused by mutations in the dystrophin gene. We characterized which isoforms...
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Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo
Direct reprogramming of fibroblasts into induced cardiomyocytes (iCMs) through microRNAs (miRNAs) is a new emerging strategy for myocardial...
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MYBPC3 deficiency in cardiac fibroblasts drives their activation and contributes to fibrosis
Genetic mutations in the MYBPC3 gene encoding cardiac myosin binding protein C (cMyBP-C) are the most common cause of hypertrophic cardiomyopathy...
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Anti-inflammatory, Anti-fibrotic and Pro-cardiomyogenic Effects of Genetically Engineered Extracellular Vesicles Enriched in miR-1 and miR-199a on Human Cardiac Fibroblasts
RationaleEmerging evidence indicates that stem cell (SC)- derived extracellular vesicles (EVs) carrying bioactive miRNAs are able to repair damaged...
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Primitive macrophages induce sarcomeric maturation and functional enhancement of develo** human cardiac microtissues via efferocytic pathways
Yolk sac macrophages are the first to seed the develo** heart; however, owing to a lack of accessible tissue, there is no understanding of their...
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Modeling acute myocardial infarction and cardiac fibrosis using human induced pluripotent stem cell-derived multi-cellular heart organoids
Heart disease involves irreversible myocardial injury that leads to high morbidity and mortality rates. Numerous cell-based cardiac in vitro models...
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Human cardiac fibroblasts produce pro-inflammatory cytokines upon TLRs and RLRs stimulation
Heart inflammation is one of the major causes of heart damage that leads to dilated cardiomyopathy and often progresses to end-stage heart failure....
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‘Youthful’ phenotype of c-Kit+ cardiac fibroblasts
Cardiac fibroblast (CF) population heterogeneity and plasticity present a challenge for categorization of biological and functional properties....
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LncRNA Airn alleviates diabetic cardiac fibrosis by inhibiting activation of cardiac fibroblasts via a m6A-IMP2-p53 axis
BackgroundCardiac fibrosis is a leading cause of cardiac dysfunction in patients with diabetes. However, the underlying mechanisms of cardiac...
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Human Stem Cell-Derived Cardiac Organoid-Like Structures: Generation and Applications
Since 2017, the interest in cardiac organoids has flourished. Their critical benefit relies on the three-dimensional organization and multicellular...
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SPRR1A is a key downstream effector of MiR-150 during both maladaptive cardiac remodeling in mice and human cardiac fibroblast activation
MicroRNA-150 (miR-150) is conserved between rodents and humans, is significantly downregulated during heart failure (HF), and correlates with patient...
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Low expression of miR-1929-3p mediates murine cytomegalovirus-induced fibrosis in cardiac fibroblasts via targeting endothelin a receptor/NLRP3 inflammasome pathway
MicroRNAs are crucial in the development of myocardial remodeling in hypertension. Low miR-1929-3p expression induced by murine cytomegalovirus...
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Vitamin C facilitates direct cardiac reprogramming by inhibiting reactive oxygen species
BackgroundAfter myocardial infarction, the lost myocardium is replaced by fibrotic tissue, eventually progressively leading to myocardial...
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Correction to: Direct Reprogramming of Adult Human Cardiac Fibroblasts into Induced Cardiomyocytes Using miRcombo
This chapter was previously published as non-Open Access. Under the request of the authors the chapter is now converted to Open Access and is...
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Recent advances and future prospects in direct cardiac reprogramming
Cardiovascular disease remains a leading cause of death worldwide despite important advances in modern medical and surgical therapies. As human adult...
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MYOCD is Required for Cardiomyocyte-like Cells Induction from Human Urine Cells and Fibroblasts Through Remodeling Chromatin
Despite direct reprogramming of human cardiac fibroblasts into induced cardiomyocytes (iCM) holds great potential for heart regeneration, the...
