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Mitophagy in human health, ageing and disease
Maintaining optimal mitochondrial function is a feature of health. Mitophagy removes and recycles damaged mitochondria and regulates the biogenesis...
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Dynamic lipidome alterations associated with human health, disease and ageing
Lipids can be of endogenous or exogenous origin and affect diverse biological functions, including cell membrane maintenance, energy management and...
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The influence of biological sex in human skeletal muscle transcriptome during ageing
Sex is a crucial biological variable, and influence of biological sex on the change of gene expression in ageing skeletal muscle has not yet been...
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Skeletal muscle myostatin mRNA expression is upregulated in aged human adults with excess adiposity but is not associated with insulin resistance and ageing
Myostatin negatively regulates skeletal muscle growth and appears upregulated in human obesity and associated with insulin resistance. However,...
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Trigonelline is an NAD+ precursor that improves muscle function during ageing and is reduced in human sarcopenia
Mitochondrial dysfunction and low nicotinamide adenine dinucleotide (NAD + ) levels are hallmarks of skeletal muscle ageing and sarcopenia
1 –3 , but it...
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Cellular and Molecular Aspects of Ageing
Even though life expectancy increased in the last decades, ageing has been considered a strong risk factor for age-related diseases, disability and...
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Measuring healthy ageing: current and future tools
Human ageing is a complex, multifactorial process characterised by physiological damage, increased risk of age-related diseases and inevitable...
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Ageing in the brain: mechanisms and rejuvenating strategies
Ageing is characterized by the progressive loss of cellular homeostasis, leading to an overall decline of the organism’s fitness. In the brain,...
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Yeast as a model for ageing and apoptosis research
Apoptosis is a form of programmed cell death with a crucial role in health and disease in metazoans. Recent findings demonstrate the existence of an...
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Ageing as a software design flaw
Ageing is inherent to all human beings, yet why we age remains a hotly contested topic. Most mechanistic explanations of ageing posit that ageing is...
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Adipose tissue as a linchpin of organismal ageing
Ageing is a conserved biological process, modulated by intrinsic and extrinsic factors, that leads to changes in life expectancy. In humans, ageing...
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Molecular hallmarks of ageing in amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a fatal, severely debilitating and rapidly progressing disorder affecting motor neurons in the brain,...
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SIRT4 in ageing
Ageing is a phenomenon in which cells, tissues and organs undergo systemic pathological changes as individuals age, leading to the occurrence of...
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Adding intrinsically disordered proteins to biological ageing clocks
Research into how the young and old differ, and which biomarkers reflect the diverse biological processes underlying ageing, is a current and...
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Transcriptomic analysis reveals a tissue-specific loss of identity during ageing and cancer
IntroductionUnderstanding changes in cell identity in cancer and ageing is of great importance. In this work, we analyzed how gene expression changes...
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A commentary on studies of brain iron accumulation during ageing
Brain iron content is widely reported to increase during “ageing”, across multiple species from nematodes, rodents (mice and rats) and humans. Given...
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PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing
Muscle degeneration is the most prevalent cause for frailty and dependency in inherited diseases and ageing. Elucidation of pathophysiological...
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Role of subcytotoxic stress in tissue ageing
Most commonly stress-induced premature senescence (SIPS) is defined as the long-term effects of subcytotoxic stress on proliferative cell types,...
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Rapid measurement of ageing by automated monitoring of movement of C. elegans populations
Finding new interventions that slow ageing and maintain human health is a huge challenge of our time. The nematode Caenorhabditis elegans offers a...
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Cannabinoids and healthy ageing: the potential for extending healthspan and lifespan in preclinical models with an emphasis on Caenorhabditis elegans
There is a significant global upsurge in the number and proportion of older persons in the population. With this comes an increasing prevalence of...
