Search
Search Results
-
Interaction of pRb and β-Catenin in Cancer and Normal Human Prostate Tissue
AbstractProstate cancer (PCa) is one of the most common oncological diseases, which passes through two stages in its development: localized PCa and...
-
Molecular evaluation of human papillomavirus as an oncogenic biomarker in prostate cancer
BackgroundProstate cancer (PCa) is one of the most common tumors in men, regardless of ethnicity and demographics. In many risk factors causing PCa,...
-
Efficient 3D light-sheet imaging of very large-scale optically cleared human brain and prostate tissue samples
The ability to image human tissue samples in 3D, with both cellular resolution and a large field of view (FOV), can improve fundamental and clinical...
-
7-Geranyloxcycoumarin enhances radio sensitivity in human prostate cancer cells
BackgroundProstate cancer is the second most prevalent and the fifth deadliest cancer among men worldwide. To improve radiotherapy outcome, we...
-
Melatonin protects against cadmium-induced oxidative stress via mitochondrial STAT3 signaling in human prostate stromal cells
Melatonin protects against Cadmium (Cd)-induced toxicity, a ubiquitous environmental toxicant that causes adverse health effects by increasing...
-
YAP is required for prostate development, regeneration, and prostate stem cell function
Prostate development and regeneration depend on prostate stem cell function, the delicate balance of stem cell self-renewal and differentiation....
-
Targeting SphK1/2 by SKI-178 inhibits prostate cancer cell growth
Sphingosine kinases (SphK), including SphK1 and SphK2, are important enzymes promoting progression of prostate cancer. SKI-178 is a novel and highly...
-
The “Ins and Outs” of Prostate Specific Membrane Antigen (PSMA) as Specific Target in Prostate Cancer Therapy
Prostate-specific membrane antigen (PSMA)PSMA is expressed in epithelial cells of the prostate gland and is strongly upregulated in prostatic...
-
Inhibition of CDKL3 downregulates STAT1 thus suppressing prostate cancer development
Prostate cancer poses a great threat to men’s health worldwide, yet its treatment is still limited by the unclear understanding of its molecular...
-
Decellularized Prostate for Cancer Studies
AbstractRegenerative medicine researchers are interested in extracellular matrix (ECM) investigations around fabricating scaffolds that mimic the...
-
Castration promotes the browning of the prostate tumor microenvironment
BackgroundAdipose tissue has gained attention due to its potential paracrine role. Periprostatic adipose tissue surrounds the prostate and the...
-
Fluorescent Conjugates Based on Prostate-Specific Membrane Antigen Ligands as an Effective Visualization Tool for Prostate Cancer
AbstractFluorescent dyes are widely used in histological studies and in intraoperative imaging, including surgical treatment of prostate cancer (PC),...
-
Knockdown of KIF15 suppresses proliferation of prostate cancer cells and induces apoptosis through PI3K/Akt signaling pathway
Prostate cancer is one of the most common malignancies in men, which has been considered a public health threat. KIF15 is a kind of driver protein,...
-
Recent advances in flavonoid compounds for the treatment of prostate cancer
Prostate cancer is a malignant epithelial tumor of the prostate gland and is the most common malignant tumor of the male genitourinary system....
-
Landscape of prostate-specific membrane antigen heterogeneity and regulation in AR-positive and AR-negative metastatic prostate cancer
Tumor expression of prostate-specific membrane antigen (PSMA) is lost in 15–20% of men with castration-resistant prostate cancer (CRPC), yet the...
-
A New Approach to Release Insoluble Curcumin into DU-145 Human Prostate Cancer Cells Through Biodegradable Polymeric Nanocarriers with Apoptosis Induction and Metastasis Inhibition
AbstractObjective: Curcumin (C 21 H 20 O 6 , CUR) is the most abundant compound in turmeric (Curcuma longa), which had antioxidant, anti-cancer and...
-
Lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of prostate carcinogenesis
This work aimed to understand how lifelong exercise training promotes the remodelling of the immune system and prostate signalome in a rat model of...
-
Identification of the mitochondrial protein POLRMT as a potential therapeutic target of prostate cancer
RNA polymerase mitochondria (POLRMT) is essential for mitochondrial transcription machinery and other mitochondrial functions. Its expression and...
-
Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment
Lineage transitions are a central feature of prostate development, tumourigenesis and treatment resistance. While epigenetic changes are well known...
-
UBE2N promotes cell viability and glycolysis by promoting Axin1 ubiquitination in prostate cancer cells
BackgroundUbiquitin-conjugating enzyme E2 N (UBE2N) is recognized in the progression of some cancers; however, little research has been conducted to...
