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APOB100 transgenic mice exemplify how the systemic circulation content may affect the retina without altering retinal cholesterol input
Apolipoprotein B (APOB) is a constituent of unique lipoprotein particles (LPPs) produced in the retinal pigment epithelium (RPE), which separates the...
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Elevated cholesteryl ester transfer and phospholipid transfer proteins aggravated psoriasis in imiquimod-induced mouse models
BackgroundPsoriasis is a chronic inflammatory skin disorder related to dyslipidemia, with decreased high-density lipoprotein (HDL). Various cell...
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Genetically Engineered Hamster Models of Dyslipidemia and Atherosclerosis
Animal models of human diseases play an extremely important role in biomedical research. Among them, mice are widely used animal models for...
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Pig and Mouse Models of Hyperlipidemia and Atherosclerosis
Atherosclerosis is a chronic inflammatory disorder that is the underlying cause of most cardiovascular disease. Resident cells of the artery wall and...
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Closing the gaps in patient management of dyslipidemia: step** into cardiovascular precision diagnostics with apolipoprotein profiling
In persons with dyslipidemia, a high residual risk of cardiovascular disease remains despite lipid lowering therapy. Current cardiovascular risk...
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Genetics of extreme human longevity to guide drug discovery for healthy ageing
Ageing is the greatest risk factor for most common chronic human diseases, and it therefore is a logical target for develo** interventions to...
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Survey of Approaches for Investigation of Atherosclerosis In Vivo
Although in vitro model systems are useful for investigation of atherosclerosis-associated processes, they represent simplification of complex events...
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Atherosclerotic Plaque Regression: Future Perspective
Atherosclerotic plaque is a complex environment in which cholesterol, phospholipids, protein, and their oxidized molecules co-exist. Many of these...
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Atherosclerosis antigens as targets for immunotherapy
Atherosclerosis is a chronic inflammatory disease of the arteries that can lead to thrombosis, infarction and stroke, underlying the first cause of...
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Residual risks and evolving atherosclerotic plaques
Atherosclerotic disease of the coronary and carotid arteries is the primary global cause of significant mortality and morbidity. The chronic...
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Chronic Exercise Reduces CETP and Mesterolone Treatment Counteracts Exercise Benefits on Plasma Lipoproteins Profile: Studies in Transgenic Mice
Regular exercise and anabolic androgenic steroids have opposing effects on the plasma lipoprotein profile and risk of cardio-metabolic diseases in...
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Nutrition in Alzheimer’s disease: a review of an underappreciated pathophysiological mechanism
Alzheimer’s disease (AD) is the leading cause of dementia in older individuals and is an escalating challenge to global public health. Pharmacy...
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A review of animal models utilized in preclinical studies of approved gene therapy products: trends and insights
Scientific progress heavily relies on rigorous research, adherence to scientific standards, and transparent reporting. Animal models play a crucial...
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Peptides as Therapeutic Agents for Atherosclerosis
More than three decades ago, as a test for the amphipathic helix theory, an 18 amino acid residue peptide and its analogs were designed with no...
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Contribution of environmental, genetic and epigenetic factors to obesity-related metabolic syndrome
Non-communicable lifestyle diseases and related mortality are increasing rapidly over the last few decades. Obesity is one of the major concerning...
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The novel molecular mechanism of pulmonary fibrosis: insight into lipid metabolism from reanalysis of single-cell RNA-seq databases
Pulmonary fibrosis (PF) is a severe pulmonary disease with limited available therapeutic choices. Recent evidence increasingly points to abnormal...
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A novel swine model for evaluation of dyslipidemia and atherosclerosis induced by human CETP overexpression
BackgroundThe mechanism of cholesteryl ester transfer protein (CETP) in lipid metabolism is still unclear. Furthermore, the relationship of CETP and...
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Determinants of high-density lipoprotein (HDL) functions beyond proteome in Asian Indians: exploring the fatty acid profile of HDL phospholipids
Impaired high-density lipoprotein (HDL) functions are associated with development of coronary artery disease. In this study, we explored the...
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The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to impaired functional ability and ultimately increased...
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Epigenetic contribution to obesity
Obesity is a worldwide epidemic and contributes to global morbidity and mortality mediated via the development of nonalcoholic fatty liver disease...
