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Machine learning techniques on homological persistence features for prostate cancer diagnosis
The rapid evolution of image processing equipment and techniques ensures the development of novel picture analysis methodologies. One of the most...
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Persistent Homology for RNA Data Analysis
Molecular representations are of great importance for machine learning models in RNA data analysis. Essentially, efficient molecular descriptors or...
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In vivo tracking of functionally tagged Rad51 unveils a robust strategy of homology search
Homologous recombination (HR) is a major pathway to repair DNA double-strand breaks (DSB). HR uses an undamaged homologous DNA sequence as a template...
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Developmental Homology
Homology Homology description is the fundamental determinant of the sameness of biological charactersBiological characters or traits. When two...
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High-efficiency transgene integration by homology-directed repair in human primary cells using DNA-PKcs inhibition
Therapeutic applications of nuclease-based genome editing would benefit from improved methods for transgene integration via homology-directed repair...
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Development of a novel SNP assay to detect lactase persistence associated genetic variants
BackgroundIn adulthood the activity of the lactase enzyme is inherited as autosomal dominant form associated to Single nucleotide polymorphisms...
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Awakening sleeper cells: a narrative review on bacterial magic spot synthetases as potential drug targets to overcome persistence
Magic spot synthetases are emerging targets to overcome persistence caused by stringent response. The ‘stringent response’ is a bacterial stress...
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Multivalency ensures persistence of a +TIP body at specialized microtubule ends
Microtubule plus-end tracking proteins (+TIPs) control microtubule specialization and are as such essential for cell division and morphogenesis. Here...
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MFCIS: an automatic leaf-based identification pipeline for plant cultivars using deep learning and persistent homology
Recognizing plant cultivars reliably and efficiently can benefit plant breeders in terms of property rights protection and innovation of germplasm...
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Effect of APOE ε4 on multimodal brain connectomic traits: a persistent homology study
BackgroundAlthough genetic risk factors and network-level neuroimaging abnormalities have shown effects on cognitive performance and brain atrophy in...
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Topological data analysis of spatial patterning in heterogeneous cell populations: clustering and sorting with varying cell-cell adhesion
Different cell types aggregate and sort into hierarchical architectures during the formation of animal tissues. The resulting spatial organization...
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Supervised topological data analysis for MALDI mass spectrometry imaging applications
BackgroundMatrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) displays significant potential for applications in cancer...
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Paradoxical implication of BAX/BAK in the persistence of tetraploid cells
Pro-apoptotic multi-domain proteins of the BCL2 family such as BAX and BAK are well known for their important role in the induction of mitochondrial...
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Protein Sorting Prediction
Many computational methods are available for predicting protein sorting in bacteria. When comparing them, it is important to know that they can be...
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Dicentric chromosomes are resolved through breakage and repair at their centromeres
Chromosomes with two centromeres provide a unique opportunity to study chromosome breakage and DNA repair using completely endogenous cellular...
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Survival of Streptococcus equi subsp. zooepidemicus on environmental samples is affected by material type and incubation temperature
Streptococcus equi subsp. zooepidemicus is an opportunistic pathogen associated with disease in a range of domestic and wild animals. Despite its...
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Developmental Homology
Homology Homology description is the fundamental determinant of the sameness of biological charactersBiological characters or traits. When two...
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Biofilms preserve the transmissibility of a multi-drug resistance plasmid
Self-transmissible multidrug resistance (MDR) plasmids are a major health concern because they can spread antibiotic resistance to pathogens. Even...
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A highly efficient transgene knock-in technology in clinically relevant cell types
Inefficient knock-in of transgene cargos limits the potential of cell-based medicines. In this study, we used a CRISPR nuclease that targets a site...
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A positive feedback loop controls Toxoplasma chronic differentiation
Successful infection strategies must balance pathogen amplification and persistence. In the obligate intracellular parasite Toxoplasma gondii this is...
