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1. Histone Modification Analysis of Low-Mappability Regions

   Posttranslational modificationsPosttranslational modifications of histoneHistone are intimately related to chromatin/chromosome-mediated cellular...

   Naoko Yoshizawa-Sugata, Hisao Masai in Chromosome Analysis

   Protocol 2023
   

2. Targeted Manipulation of Histone Modification in Medaka Embryos

   Recent development of targeted manipulation of histone modification enables us to experimentally and directly test the functional relevance of...

   Hiroto S. Fukushima, Hiroyuki Takeda, Ryohei Nakamura in Epigenomics

   Protocol 2023
   

3. Evaluating histone modification analysis of individual preimplantation embryos

   Background

   We previously reported a modification of the CUT&Tag method (NTU-CAT) that allows genome-wide histone modification analysis in individual...

   Yiren Zeng, Yoichiro Hoshino, ... Shuntaro Ikeda in BMC Genomics

   Article Open access 18 January 2024
   

4. Epigenetic mechanisms of Immune remodeling in sepsis: targeting histone modification

   Sepsis is a life-threatening disorder disease defined as infection-induced dysregulated immune responses and multiple organ dysfunction. The...

   Dan Wu, Yuxin Shi, ... Changhong Miao in Cell Death & Disease

   Article Open access 11 February 2023
   

5. The Role of Histone H2B Acetylation Modification in Aluminum-Induced Cognitive Dysfunction

   Aluminum (Al) is a low toxic trace element that can accumulate in the nervous system and induce cognitive disorders characterized by reduced learning...

   Jie Gao, Wei Liu, ... Lifeng Zhang in Biological Trace Element Research

   Article 18 November 2023
   

6. Predicting active enhancers with DNA methylation and histone modification

   Background

   Enhancers play a crucial role in gene regulation, and some active enhancers produce noncoding RNAs known as enhancer RNAs (eRNAs)...

   **mei Luo, Qun Li, ... Lei Xu in BMC Bioinformatics

   Article Open access 02 November 2023
   

7. Histone modification landscape and the key significance of H3K27me3 in myocardial ischaemia/reperfusion injury

   Histone modifications play crucial roles in the pathogenesis of myocardial ischaemia/reperfusion (I/R) injury. However, a genome-wide map of histone...

   Le Ni, Bowen Lin, ... Yi-Han Chen in Science China Life Sciences

   Article 13 February 2023

8. Investigating Histone Modification Dynamics by Mechanistic Computational Modeling

   The maintenance of transcriptional states regulated by histone modifications and controlled switching between these states are fundamental concepts...

   Govind Menon, Martin Howard in Histone Methyltransferases

   Protocol 2022
   

9. GoPeaks: histone modification peak calling for CUT&Tag

   Genome-wide map** of histone modifications is critical to understanding transcriptional regulation. CUT&Tag is a new method for profiling histone...

   William M. Yashar, Garth Kong, ... Theodore P. Braun in Genome Biology

   Article Open access 04 July 2022
   

10. Multi-omics approaches establishing histone modification based prognostic model in glioma patients and further verification of the carcinogenesis mechanism

    Glioblastoma (GBM) emerges as the most common malignant brain tumor. Histone modifications, as an epigenetic regulatory mechanism of gene expression,...

    Yunhui Wang, LiKang Ji, ... Fan Wang in Functional & Integrative Genomics

    Article 21 September 2023
    

11. The Generation and Recognition of Histone Methylation

    The posttranslational modification of histone proteins via methylation has important functions in gene activation, transcriptional silencing,...

    Michael S. Torok, Patrick A. Grant in Chromatin Dynamics in Cellular Function

    Chapter
    

12. Allele-specific binding variants causing ChIP-seq peak height of histone modification are not enriched in expression QTL annotations

    Background

    Genome sequence variants affecting complex traits (quantitative trait loci, QTL) are enriched in functional regions of the genome, such as...

    Mohammad Ghoreishifar, Amanda J. Chamberlain, ... Michael E. Goddard in Genetics Selection Evolution

    Article Open access 27 June 2024
    

13. DNA Methylation and Histone Modification in Dental-derived Mesenchymal Stem Cells

    Abstract

    Epigenetic regulation, mainly involving DNA methylation, histone modification, and noncoding RNAs (ncRNAs), is essential for the regulation...

    Biyun Zeng, Gui Liu, Junhui Huang in Stem Cell Reviews and Reports

    Article 27 July 2022
    

14. Lysine acetylation of histone acetyltransferase adaptor protein ADA2 is a mechanism of metabolic control of chromatin modification in plants

    Histone acetylation is a predominant active chromatin mark deposited by histone acetyltransferases (HATs) that transfer the acetyl group from acetyl...

    Yue Yu, Feng Zhao, ... Dao-**u Zhou in Nature Plants

    Article 07 February 2024
    

15. Sub-Chronic Aluminum Exposure in Rats’ Learning-Memory Capability and Hippocampal Histone H4 Acetylation Modification: Effects and Mechanisms

    Aluminum has been found to be closely related to the pathogenesis of neurodegenerative diseases and damage learning and memory functions. Many...

    Jie Gao, Shiming Zhang, ... Lifeng Zhang in Biological Trace Element Research

    Article 24 February 2023
    

16. Metformin Promotes Proliferation of Mouse Female Germline Stem Cells by Histone Acetylation Modification of Traf2

    Female germline stem cells (FGSCs) are adult stem cells that can both self-renew and differentiate into mature oocytes. Although small-molecule...

    Jiaqi Chen, Lu Wang, ... Ji Wu in Stem Cell Reviews and Reports

    Article 24 June 2023
    

17. The histone modification reader ZCWPW1 promotes double-strand break repair by regulating cross-talk of histone modifications and chromatin accessibility at meiotic hotspots

    Background

    The PRDM9-dependent histone methylation H3K4me3 and H3K36me3 function in assuring accurate homologous recombination at recombination...

    Shenli Yuan, Tao Huang, ... Zi-Jiang Chen in Genome Biology

    Article Open access 06 September 2022
    

18. Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2

    Histone lysine crotonylation is a posttranslational modification with demonstrated functions in transcriptional regulation. Here we report the...

    Kyle Delaney, Minjia Tan, ... Yingming Zhao in Cell Discovery

    Article Open access 28 December 2021
    

19. Whole-genome landscape of histone H3K4me3 modification during sperm cell lineage development in tomato

    Background

    During male gametogenesis of flowering plants, sperm cell lineage (microspores, generative cells, and sperm cells) differentiated from...

    Yunyun Song, Zhikai Chang, ... Lingtong Liu in BMC Plant Biology

    Article Open access 27 June 2024
    

20. A benchmark of computational pipelines for single-cell histone modification data

    Background

    Single-cell histone post translational modification (scHPTM) assays such as scCUT&Tag or scChIP-seq allow single-cell map** of diverse...

    Félix Raimundo, Pacôme Prompsy, ... Céline Vallot in Genome Biology

    Article Open access 20 June 2023