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E2 enzyme Bruce negatively regulates Hippo signaling through POSH-mediated expanded degradation
The Hippo pathway is a master regulator of organ growth, stem cell renewal, and tumorigenesis, its activation is tightly controlled by various...
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USP1 modulates hepatocellular carcinoma progression via the Hippo/TAZ axis
Hepatocellular carcinoma (HCC) is one of the most lethal malignancies worldwide. The Hippo signaling pathway has emerged as a significant suppressive...
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The roles of Hippo/YAP signaling pathway in physical therapy
Cellular behavior is regulated by mechanical signals within the cellular microenvironment. Additionally, changes of temperature, blood flow, and...
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LncRNA-SNHG5 mediates activation of hepatic stellate cells by regulating NF2 and Hippo pathway
Long noncoding RNA small nucleolar RNA host gene 5 (SNHG5) is an oncogene found in various human cancers. However, it is unclear what role SNHG5...
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The LKB1–TSSK1B axis controls YAP phosphorylation to regulate the Hippo–YAP pathway
The Hippo pathway’s main effector, Yes-associated protein (YAP), plays a crucial role in tumorigenesis as a transcriptional coactivator. YAP’s...
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The AAA-ATPase Ter94 regulates wing size in Drosophila by suppressing the Hippo pathway
Insect wing development is a fascinating and intricate process that involves the regulation of wing size through cell proliferation and apoptosis. In...
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HIPPO: HIstogram-based Pseudo-POtential for scoring protein-ssRNA fragment-based docking poses
BackgroundThe RNA-Recognition motif (RRM) is a protein domain that binds single-stranded RNA (ssRNA) and is present in as much as 2% of the human...
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Bcl-2 dependent modulation of Hippo pathway in cancer cells
IntroductionBcl-2 and Bcl-xL are the most studied anti-apoptotic members of Bcl-2 family proteins. We previously characterized both of them, not only...
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Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing
The overlap** roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions....
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YY1 modulates the radiosensitivity of esophageal squamous cell carcinoma through KIF3B-mediated Hippo signaling pathway
Radiotherapy is an important strategy in the comprehensive treatment of esophageal squamous cell carcinoma (ESCC). However, effectiveness of...
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Neuronopathic Gaucher disease models reveal defects in cell growth promoted by Hippo pathway activation
Gaucher Disease (GD), the most common lysosomal disorder, arises from mutations in the GBA1 gene and is characterized by a wide spectrum of...
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Non-hippo kinases: indispensable roles in YAP/TAZ signaling and implications in cancer therapy
The transcriptional co-activators Yes-associated protein (YAP) and PDZ-binding domain (TAZ) are the known downstream effectors of the Hippo kinase...
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Hippo kinases Mst1 and Mst2 maintain NK cell homeostasis by orchestrating metabolic state and transcriptional activity
Natural killer (NK) cells play a crucial role in immune response against viral infections and tumors. However, further investigation is needed to...
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FRMD6 determines the cell fate towards senescence: involvement of the Hippo-YAP-CCN3 axis
Cellular senescence, a hallmark of aging, is pathogenically linked to the development of aging-related diseases. This study demonstrates that FRMD6,...
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Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers
The YAP–TEAD protein–protein interaction mediates YAP oncogenic functions downstream of the Hippo pathway. To date, available YAP–TEAD pharmacologic...
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Hippo signaling pathway and respiratory diseases
The hippo signaling pathway is a highly conserved evolutionary signaling pathway that plays an important role in regulating cell proliferation, organ...
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GPR137 inactivates Hippo signaling to promote gastric cancer cell malignancy
As the fifth most common cancer in the world, gastric cancer (GC) ranks as the third major cause of cancer-related death globally. Although surgical...
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Shaggy regulates tissue growth through Hippo pathway in Drosophila
The evolutionarily conserved Hippo pathway coordinates cell proliferation, differentiation and apoptosis to regulate organ growth and tumorigenesis....
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Hippo pathway dysregulation in gastric cancer: from Helicobacter pylori infection to tumor promotion and progression
The Hippo pathway plays a critical role for balancing proliferation and differentiation, thus regulating tissue homeostasis. The pathway acts through...
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CYLD regulates cell ferroptosis through Hippo/YAP signaling in prostate cancer progression
Prostate cancer (PCa) is one of the most common malignancy in men. However, the molecular mechanism of its pathogenesis has not yet been elucidated....
