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GREM1/PPP2R3A expression in heterogeneous fibroblasts initiates pulmonary fibrosis
BackgroundFibroblasts have important roles in the synthesis and remodeling of extracellular matrix (ECM) proteins during pulmonary fibrosis. However,...
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scINSIGHT for interpreting single-cell gene expression from biologically heterogeneous data
The increasing number of scRNA-seq data emphasizes the need for integrative analysis to interpret similarities and differences between single-cell...
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Heterogeneous pseudobulk simulation enables realistic benchmarking of cell-type deconvolution methods
BackgroundComputational cell type deconvolution enables the estimation of cell type abundance from bulk tissues and is important for understanding...
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Data-driven identification of total RNA expression genes for estimation of RNA abundance in heterogeneous cell types highlighted in brain tissue
We define and identify a new class of control genes for next-generation sequencing called total RNA expression genes (TREGs), which correlate with...
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AMPFLDAP: Adaptive Message Passing and Feature Fusion on Heterogeneous Network for LncRNA-Disease Associations Prediction
Exploration of the intricate connections between long noncoding RNA (lncRNA) and diseases, referred to as lncRNA-disease associations (LDAs), plays a...
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Study on the mechanism of heterogeneous tumor-associated macrophages in three subtypes of breast cancer through the integration of single-cell RNA sequencing and in vitro experiments
BackgroundTumor-associated macrophages (TAM) exert a significant influence on the progression and heterogeneity of various subtypes of breast cancer...
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Heterogeneous expression and role of receptor tyrosine kinase-like orphan receptor 2 (ROR2) in small cell lung cancer
The present study investigated the expression and role of ROR2 in small cell lung cancer (SCLC). To examine the expression of ROR2, 27 surgically...
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Heterogeneous Cells as well as Adipose-Derived Stromal Cells in Stromal Vascular Fraction Contribute to Enhance Anabolic and Inhibit Catabolic Factors in Osteoarthritis
The stromal-vascular fraction (SVF), comprising heterogeneous cell populations and adipose-derived stromal cells (ADSCs), has therapeutic potential...
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A heterogeneous graph convolutional attention network method for classification of autism spectrum disorder
BackgroundAutism spectrum disorder (ASD) is a serious developmental disorder of the brain. Recently, various deep learning methods based on...
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Zoom-in to molecular mechanisms underlying root growth and function under heterogeneous soil environment and abiotic stresses
Main conclusionThe review describes tissue-specific and non-cell autonomous molecular responses regulating the root system architecture and function...
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Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas
BackgroundPaediatric-type diffuse High-Grade Gliomas (PDHGG) are highly heterogeneous tumours which include distinct cell sub-populations co-existing...
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Heterogeneous co-supplies of phosphorus, sulfur and carbon enhance phosphorus availability by improving rhizosphere processes in a calcareous soil
Background and aimsPhosphorus (P) availability in calcareous soils is limited. Acidifying the soil by adding sulfur (S) or enhancing microbial...
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Heterogeneous Group of Fish Response to Escape Reaction
The response of heterogeneous groups of fish including a few leaders, several followers, and a few fish initiating escape reaction is investigated....
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In vitro-generated human muscle reserve cells are heterogeneous for Pax7 with distinct molecular states and metabolic profiles
BackgroundThe capacity of skeletal muscles to regenerate relies on Pax7 + muscle stem cells (MuSC). While in vitro-amplified MuSC are activated and...
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Protein function annotation based on heterogeneous biological networks
BackgroundAccurate annotation of protein function is the key to understanding life at the molecular level and has great implications for biomedicine...
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Characterizing heterogeneous single-cell dose responses computationally and experimentally using threshold inhibition surfaces and dose-titration assays
Single cancer cells within a tumor exhibit variable levels of resistance to drugs, ultimately leading to treatment failures. While tumor...
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Investigating Heterogeneous Cell-Cycle Progression Using Single-Cell Imaging Approaches
Investigating cell-cycle progression has been challenging due to the complex interconnectivity of regulatory processes and inherent cell-to-cell...
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Androgen receptor variant shows heterogeneous expression in prostate cancer according to differentiation stage
Quantitation of androgen receptor variant (AR-V) expression in circulating tumor cells (CTCs) from patients with metastatic castration-resistant...
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HMCDA: a novel method based on the heterogeneous graph neural network and metapath for circRNA-disease associations prediction
Circular RNA (CircRNA) is a type of non-coding RNAs in which both ends are covalently linked. Researchers have demonstrated that many circRNAs can...
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Harmonizing heterogeneous transcriptomics datasets for machine learning-based analysis to identify spaceflown murine liver-specific changes
NASA has employed high-throughput molecular assays to identify sub-cellular changes impacting human physiology during spaceflight. Machine learning...
