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Hepatic Sirt6 activation abrogates acute liver failure
Acute liver failure (ALF) is a deadly illness due to insufficient detoxification in liver induced by drugs, toxins, and other etiologies, and the...
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Cryopreserved cGMP-compliant human pluripotent stem cell-derived hepatic progenitors rescue mice from acute liver failure through rapid paracrine effects on liver cells
BackgroundLiver transplantation remains the only curative treatment for end-stage liver diseases. Unfortunately, there is a drastic organ donor...
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In vivo reprogramming leads to premature death linked to hepatic and intestinal failure
The induction of cellular reprogramming via expression of the transcription factors Oct4 , Sox2 , Klf4 and c‐Myc (OSKM) can drive dedifferentiation of...
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Programmed cell death in hepatic fibrosis: current and perspectives
The initiation, development and resolution of hepatic fibrosis are influenced by various cytokines, chemokines, damage-associated molecular patterns...
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Segmentation algorithm can be used for detecting hepatic fibrosis in SD rat
BackgroundLiver fibrosis is an early stage of liver cirrhosis. As a reversible lesion before cirrhosis, liver failure, and liver cancer, it has been...
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GPR120 induces regulatory dendritic cells by inhibiting HK2-dependent glycolysis to alleviate fulminant hepatic failure
Fulminant hepatic failure (FHF) is a potentially fatal liver disease that is associated with intrahepatic infiltration of inflammatory cells. As the...
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Testing Cell Migration, Invasion, Proliferation, and Apoptosis in Hepatic Stellate Cells
The hepatic wound repair process involves cell types including healthy and injured hepatocytes, Kupffer and inflammatory cells, sinusoidal...
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MSCs Ameliorate Hepatic IR Injury by Modulating Phenotypic Transformation of Kupffer Cells Through Drp-1 Dependent Mitochondrial Dynamics
BackgroundHepatic ischemia and reperfusion (IR) injury, characterized by reactive oxygen species (ROS) production and immune disorders, leads to...
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The Beneficial Influence of Testosterone in Hepatic Ischemia/Reperfusion Injury and Its Possible Mechanisms
AbstractMost studies have indicated that the sex hormone estrogen is hepatoprotective, but little attention has been paid to investigating the effect...
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Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice
Under normal conditions, insulin promotes hepatic de novo lipogenesis (DNL). However, during insulin resistance (IR), when insulin signalling is...
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Impaired hepatic autophagy exacerbates hepatotoxin induced liver injury
Hepatotoxins activate the hepatic survival pathway, but it is unclear whether impaired survival pathways contribute to liver injury caused by...
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Downregulation of HNF4A enables transcriptomic reprogramming during the hepatic acute-phase response
The hepatic acute-phase response is characterized by a massive upregulation of serum proteins, such as haptoglobin and serum amyloid A, at the...
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Ufmylation on UFBP1 alleviates non-alcoholic fatty liver disease by modulating hepatic endoplasmic reticulum stress
Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease characterized by lipid accumulation and endoplasmic reticulum (ER) stress,...
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The miR-3074/BMP7 axis regulates TGF-β-caused activation of hepatic stellate cells in vitro and CCl4-caused murine liver fibrosis in vivo
Continuously progressive hepatic fibrosis might cause chronic liver diseases, resulting in hepatic failure. The activation of hepatic stellate cells...
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Nuclear receptor corepressors non-canonically drive glucocorticoid receptor-dependent activation of hepatic gluconeogenesis
Nuclear receptor corepressors (NCoRs) function in multiprotein complexes containing histone deacetylase 3 (HDAC3) to alter transcriptional output...
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Kupffer cells abrogate homing and repopulation of allogeneic hepatic progenitors in injured liver site
BackgroundAllogeneic hepatocyte transplantation is an emerging approach to treat acute liver defects. However, durable engraftment of the...
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Ephrin–Eph receptor tyrosine kinases for potential therapeutics against hepatic pathologies
AbstractHepatic fibrosis is the common pathological change that occurs due to increased synthesis and accumulation of extracellular matrix...
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Liver organoids cocultured on decellularized native liver scaffolds as a bridging therapy improves survival from liver failure in rabbits
The present study aimed to develop viable liver organoids using decellularized native liver scaffolds and evaluate the efficacy of human liver...
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lncRNA Helf promotes hepatic inflammation and fibrosis by interacting with PTBP1 to facilitate PIK3R5 mRNA stabilization
BackgroundHepatic fibrosis is a common consequence of chronic liver diseases without approved antifibrotic therapies. Long noncoding RNAs (lncRNAs)...
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MafG/MYH9-LCN2 axis promotes liver fibrosis through inhibiting ferroptosis of hepatic stellate cells
Hepatic stellate cells (HSCs) secrete extracellular matrix for collagen deposition, contributing to liver fibrosis. Ferroptosis is a novel type of...
