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MHY1485 promotes adriamycin sensitivity in HepG2 cells by inhibiting autophagy
MHY1485 is an mTOR activator that inhibits the autophagy process by inhibiting the fusion between autophagosomes and lysosomes. This study aimed to...
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LncRNA MEG3 Restrains Hepatic Lipogenesis via the FOXO1 Signaling Pathway in HepG2 Cells
Nonalcoholic fatty liver disease (NAFLD) become a main public health concern, and is characterized by lipid accumulation in the hepatocytes. We found...
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Effects of Progesterone and Selective Ligands of Membrane Progesterone Receptors in HepG2 Cells of Human Hepatocellular Carcinoma
AbstractProgesterone exerts multiple effects in different tissues through nuclear receptors (nPRs) and through membrane receptors (mPRs) of...
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Epigallocatechin gallate induces an up-regulation of LDLR accompanied by a reduction of idol in Hepg2 cells
Epigallocatechin gallate (EGCG), the primary catechin in green tea, has improved cholesterol metabolism. However, the molecular mechanisms of EGCG...
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Antitumor activity of bovine lactoferrin and its derived peptides against HepG2 liver cancer cells and Jurkat leukemia cells
Liver cancer and leukemia are the fourth and first causes, respectively, of cancer death in children and adults worldwide. Moreover, cancer...
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Phytochemical profile of Euphorbia hirta plant extract and its in vitro anticancer activity against the liver cancer HepG2 cells
Recently, the plants-derived bioactive components received a greater interests due to their significant anti-carcinogenic properties. Euphorbia hirta ...
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Adiponectin Stimulates Apolipoprotein A-1 Gene Expression in HepG2 Cells via AMPK, PPARα, and LXRs Signaling Mechanisms
AbstractAdiponectin is an adipose tissue hormone, participating in energy metabolism and involved in atherogenesis. Previously, it was found that...
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Direct and macrophage stimulation mediated effects of active, inactive, and cell-free supernatant forms of Akkermansia muciniphila and Faecalibacterium duncaniae on hepcidin gene expression in HepG2 cells
Hepcidin is a crucial regulator of iron homeostasis with protective effects on liver fibrosis. Additionally, gut microbiota can also affect liver...
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Characterization of chikusetsusaponin IV and V induced apoptosis in HepG2 cancer cells
BackgroundChikusetsusaponin IV and V (CsIV and CsV), two typical oleanolic acid saponins, are mainly derived from the rhizome of Panax japonicus ...
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Unravelling effects of phytochemicals from buckwheat on cholesterol metabolism and lipid accumulation in HepG2 cells and its validation through gene expression analysis
BackgroundThe objective of this research was to elucidate the hypocholesterolemic effects of a bioactive compound extracted from buckwheat, and to...
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Arecoline promotes proliferation and migration of human HepG2 cells through activation of the PI3K/AKT/mTOR pathway
BackgroundArecoline is a well-known risk factor for oral submucosal fibrosis and cancer. However, the mechanistic correlation between arecoline and...
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Protopanaxadiol Targeting Membrane Induces HepG2 Cell Apoptosis Via Raft-like Formation and Tubulation Disruption
Protopanaxadiol (PPD), which has a molecular structure similar to cholesterol, is a potent anticancer agent that has been proposed to target the...
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Chlorogenic acid improves anti-lipogenic activity of metformin by positive regulating of AMPK signaling in HepG2 cells
Metformin improves lipid profile, however, combination therapy is develo** to increase its effectiveness and reduce the deleterious effects of...
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Biochemical effects of copper nanomaterials in human hepatocellular carcinoma (HepG2) cells
In dose-response and structure-activity studies, human hepatic HepG2 cells were exposed for 3 days to nano Cu, nano CuO or CuCl 2 (ions) at doses...
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Analytical Methods and Bioassays for Cytotoxicity and Antidiabetic Properties of Aquilaria crassna Leaf Extracts in HepG2 Cells
Aquilaria crassna is a herbal plant that has recently been reported to possess several biological activities. A. crassna leaf extracts have been...
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Effects of an aryl hydrazone derivative of naproxen on HepG2 liver cancer and HGF gingival fibroblasts cell lines
Nonsteroidal anti-inflammatory drugs are suggested to have anti-cancer effects in many studies, but elucidation of mode of action remains a...
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Study of anticancer effects of platinum levetiracetam and levetiracetam via cancer biomarkers genes expression on HepG2 cell line
BackgroundHigh expression of some anticancer biomarkers such as telomerase and B cell lymphoma-2 ( Bcl-2), microRNA-21(miRNA-21), and low expression...
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Antioxidant and protective effects of a peptide (VTAL) derived from simulated gastrointestinal digestion of protein hydrolysates of Magallana gigas against acetaminophen-induced HepG2 cells
Oxidative stress is an automatic mechanism responsible for the commencement and continuance of liver injury. In this study, an antioxidative peptide...
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Anti-hyperglycemic effects of Eryngium billardierei F. Delaroche extract on insulin-resistance HepG2 cells in vitro
BackgroundInsulin resistance as a major problem is associated with type 2 diabetes mellitus. This study investigated the effect of Eryngium...
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GRP78/BiP alleviates oxLDL-induced hepatotoxicity in familial hypercholesterolemia caused by missense variants of LDLR in a HepG2 cellular model
Background and aimsThe accumulation of misfolded proteins, encoded by genetic variants of functional genes leads to Endoplasmic Reticulum (ER)...
