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Hematopoietic Stem Cells Methods and Protocols
This detailed volume collects updates on the technical advances in hematopoietic stem cell research and incorporates new techniques focused on the...
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Base Editing of Human Hematopoietic Stem Cells
Base editing by nucleotide deaminases linked to programmable DNA-binding proteins represents a promising approach to remedy blood disorders. Here we...
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Influential factors for optimizing and strengthening mesenchymal stem cells and hematopoietic stem cells co-culture
Mesenchymal stem cells (MSCs) and Hematopoietic stem cells (HSCs) are two types of bone marrow stem cells that can proliferate and differentiate into...
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The Factory of Blood Production: Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) support the lifelong production of hundreds of billions of blood cells per day. This unique, incredible ability of...
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Detection of DNA Damage in Hematopoietic Stem Cells
Single-cell gel electrophoresis (SCGE or Comet assay) and the Fast Halo assay, also known as the Halo assay, are powerful tools to generate DNA...
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Identification of Nonhuman Primate Hematopoietic Stem and Progenitor Cells
The preclinical development of hematopoietic stem cell (HSC) gene therapy/editing and transplantation protocols is frequently performed in large...
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Assessment of Ferroptosis in Hematopoietic Stem and Progenitor Cells
Hematopoietic stem cells (HSCs) are critical for maintaining hematopoiesis throughout life by utilizing their self-renewing and multipotent...
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Mesenchymal stem/stromal cells from human pluripotent stem cell-derived brain organoid enhance the ex vivo expansion and maintenance of hematopoietic stem/progenitor cells
BackgroundMesenchymal stem/stromal cells (MSCs) are of great therapeutic value due to their role in maintaining the function of hematopoietic...
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CRISPR Gene Editing of Hematopoietic Stem and Progenitor Cells
Genetic editing of hematopoietic stem and progenitor cells can be employed to understand gene-function relationships underlying hematopoietic cell...
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Age-related noncanonical TRMT6–TRMT61A signaling impairs hematopoietic stem cells
Aged hematopoietic stem cells (HSCs) exhibit compromised reconstitution capacity and differentiation bias toward myeloid lineages. However, the...
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Generating hematopoietic cells from human pluripotent stem cells: approaches, progress and challenges
Human pluripotent stem cells (hPSCs) have been suggested as a potential source for the production of blood cells for clinical application. In two...
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Effect of Post-transplant Dietary Restriction on Hematopoietic Reconstitution and Maintenance of Reconstitution Capacity of Hematopoietic Stem Cells
Hematopoietic cell transplantation (HCT) is an important therapy for many hematological malignancies as well as some non-malignant diseases....
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Isolation and Characterization of Fetal Liver Hematopoietic Stem Cells
Hematopoietic stem cells (HSCs) are responsible for the generation and maintenance of pools of multipotent precursors that ultimately give rise to...
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Repopulating Kupffer cells originate directly from hematopoietic stem cells
BackgroundKupffer cells (KCs) originate from yolk-sac progenitors before birth. Throughout adulthood, they self-maintain independently from the input...
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The “Mystery Cell Population” Residing in Murine Bone Marrow – A Missing Link Between Very Small Embryonic Like Stem Cells and Hematopoietic Stem Cells?
Bone marrow (BM) contains not only hematopoietic stem cells (HSCs) but also some very rare, early development, small quiescent stem cells that, upon...
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Hematopoietic Stem Cell Identification Postirradiation
Radiation exposure is particularly damaging to cells of the hematopoietic system, inducing pancytopenia and bone marrow failure. The study of these...
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Rapid activation of hematopoietic stem cells
Adult hematopoietic stem cells (HSCs) in the bone marrow (BM) are quiescent. Following perturbations, such as blood loss or infection, HSCs may...
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Leading Edge Techniques in the Quest for Characterizing Rare Hematopoietic Stem Cells
Purpose of ReviewHematopoietic stem cells (HSCs) occupy the summit of the intricate hematopoiesis hierarchy, constituting a mere 0.01% of the adult...
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Long-term expansion of human hematopoietic stem cells
Hematopoietic stem cells (HSCs) are critical for the treatment of a variety of hematological diseases. However, the low number of HSCs lead to the...
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Enhancing prime editing in hematopoietic stem and progenitor cells by modulating nucleotide metabolism
Therapeutic prime editing of hematopoietic stem and progenitor cells (HSPCs) holds great potential to remedy blood disorders. Quiescent cells have...
