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GPR161 structure uncovers the redundant role of sterol-regulated ciliary cAMP signaling in the Hedgehog pathway
The orphan G protein-coupled receptor (GPCR) GPR161 plays a central role in development by suppressing Hedgehog signaling. The fundamental basis of...
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CHL1 promotes autophagy and apoptosis of multiple myeloma cells via inhibiting the Hedgehog pathway
BackgroundMultiple myeloma (MM) is a common type of hematological malignancy. Cell adhesion molecule L1 (CHL1) can regulate the progression of a...
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The impact of the Hedgehog signal pathway on the tumor immune microenvironment of gastric adenocarcinoma by integrated analysis of scRNA-seq and RNA-seq datasets
The Hedgehog signaling is a highly conserved pathway to regulate cell growth and proliferation, and plays an essential role in stomach adenocarcinoma...
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Activation of the Hedgehog signaling pathway leads to fibrosis in aortic valves
BackgroundFibrosis is a pathological wound healing process characterized by excessive extracellular matrix deposition, which interferes with normal...
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The HEDGEHOG-GLI1 pathway is important for fibroproliferative properties in keloids and as a candidate therapeutic target
Keloids are benign fibroproliferative skin tumors caused by aberrant wound healing that can negatively impact patient quality of life. The lack of...
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Hedgehog Signaling Methods and Protocols
This detailed book explores the technical breakthroughs with biophysical and cell biological approaches that have advanced the study of molecular...
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Distraction force promotes the osteogenic differentiation of Gli1+ cells in facial sutures via primary cilia-mediated Hedgehog signaling pathway
BackgroundTrans-sutural distraction osteogenesis (TSDO) involves the application of distraction force to facial sutures to stimulate osteogenesis....
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Cellular and molecular mechanisms of Hedgehog signalling
The Hedgehog signalling pathway has crucial roles in embryonic tissue patterning, postembryonic tissue regeneration, and cancer, yet aspects of...
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Targeting the hedgehog pathway in MET mutation cancers and its effects on cells associated with cancer development
The mutation of MET plays a crucial role in the initiation of cancer, while the Hedgehog (Hh) pathway also plays a significant role in cell...
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The Immunofluorescence-Based Detection of Hedgehog Pathway Components in Primary Cilia of Cultured Cells
The primary cilium is a microtubule-based organelle that projects from the surface of vertebrate cells. Defects in the biogenesis of or transport...
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Anethole improves the developmental competence of porcine embryos by reducing oxidative stress via the sonic hedgehog signaling pathway
BackgroundAnethole (AN) is an organic antioxidant compound with a benzene ring and is expected to have a positive impact on early embryogenesis in...
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piRNAs regulate a Hedgehog germline-to-soma pro-aging signal
The reproductive system regulates somatic aging through competing anti- and pro-aging signals. Germline removal extends somatic lifespan through...
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Mir-326 potentiates radiosensitivity of cervical squamous cell carcinoma through downregulating SMO expression in the Hedgehog signaling pathway
BackgroundRadiotherapy resistance affects the therapeutic effect of cervical squamous cell carcinoma (CSCC). Smoothened (Smo) is an anticancer target...
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The presynaptic glycine transporter GlyT2 is regulated by the Hedgehog pathway in vitro and in vivo
The identity of a glycinergic synapse is maintained presynaptically by the activity of a surface glycine transporter, GlyT2, which recaptures glycine...
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RETRACTED ARTICLE: Hedgehog signaling-related genomics signature for the accurate progress and prognosis prediction in gastric cancer
The Hedgehog pathway is thought to be closely associated with the progression of GC; however, a specific link between the Hedgehog pathway on the...
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Emerging roles of the Hedgehog signalling pathway in inflammatory bowel disease
The Hedgehog (Hh) signalling pathway plays a critical role in the growth and patterning during embryonic development and maintenance of adult tissue...
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Hedgehog signalling is involved in acquired resistance to KRASG12C inhibitors in lung cancer cells
Although KRAS G12C inhibitors have shown promising activity in lung adenocarcinomas harbouring KRAS G12C , acquired resistance to these therapies...
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PDLIM3 supports hedgehog signaling in medulloblastoma by facilitating cilia formation
Elevated levels of PDLIM3 expression are frequently detected in sonic hedgehog (SHH) group of medulloblastoma (MB). However, the possible role of...
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Hippo signaling activates hedgehog signaling by Taz-driven Gli3 processing
The overlap** roles of Hippo and Hedgehog signaling in biological functions and diseases prompt us to investigate their potential interactions....
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Control of the Hedgehog pathway by compartmentalized PKA in the primary cilium
The Hedgehog (Hh) signaling is one of the essential signaling pathways during embryogenesis and in adults. Hh signal transduction relies on primary...