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GDF1 ameliorates cognitive impairment induced by hearing loss
Hearing loss is associated with an increased risk of Alzheimer disease (AD). However, the mechanisms of hearing loss promoting the onset of AD are...
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Natural products: protective effects against sensorineural hearing loss
Hearing loss is one of the major public health problems in the world, which brings huge adverse effects to individuals and society. Sensorineural...
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Novel pathogenic WHRN variant causing hearing loss in a moroccan family
ObjectivesThe most prevalent sensory disease in humans is deafness. A variety of genes have been linked to hearing loss, which can either be isolated...
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Advances in the Study of Etiology and Molecular Mechanisms of Sensorineural Hearing Loss
Sensorineural hearing loss (SNHL), a multifactorial progressive disorder, results from a complex interplay of genetic and environmental factors, with...
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Serum lipid metabolism characteristics and potential biomarkers in patients with unilateral sudden sensorineural hearing loss
BackgroundGlycerophospholipids (GPLs) are essential for cell membrane structure and function. Sphingomyelin and its metabolites regulate cell growth,...
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Hearing loss and vestibular schwannoma: new insights into Schwann cells implication
Hearing loss (HL) is the most common and heterogeneous disorder of the sensory system, with a large morbidity in the worldwide population. Among...
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Identification of common stria vascularis cellular alteration in sensorineural hearing loss based on ScRNA-seq
BackgroundThe stria vascularis (SV), located in the lateral wall of the cochlea, maintains cochlear fluid homeostasis and mechanoelectrical...
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Identification of novel and known genetic variants associated with hereditary hearing loss in iranian families using whole exome sequencing
BackgroundHearing loss (HL) is a common sensory impairment worldwide, with genetic and environmental factors contributing to its occurrence. Next...
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Electroencephalogram-based objective assessment of cognitive function level associated with age-related hearing loss
Age-Related Hearing Loss (ARHL) is a common problem in aging. Numerous longitudinal cohort studies have revealed that ARHL is closely related to...
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The applications of CRISPR/Cas-mediated genome editing in genetic hearing loss
Hearing loss (HL) can be caused by a number of different genetic factors. Non-syndromic HL refers that HL occurs as an isolated symptom in an...
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A potassium channel agonist protects hearing function and promotes outer hair cell survival in a mouse model for age-related hearing loss
Age-related hearing loss (ARHL) is the most common sensory impairment mainly caused by degeneration of sensory hair cells in the cochlea with no...
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d-Galactose and Hypoxia Induce the Early Onset of Age-Related Hearing Loss Deterioration in a Mouse Model
Background:We previously showed that aging accelerates after 3 months of exposure to hypoxia and environmental change but not genetic modifications....
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Population-scale analysis of common and rare genetic variation associated with hearing loss in adults
To better understand the genetics of hearing loss, we performed a genome-wide association meta-analysis with 125,749 cases and 469,497 controls...
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Comprehensive analysis of N6-methyladenosine-related RNA methylation in the mouse hippocampus after acquired hearing loss
BackgroundThe mechanism underlying cognitive impairment after hearing loss (HL) remains unclear. N6-methyladenosine (m6A) is involved in many...
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Biallelic mutations in pakistani families with autosomal recessive prelingual nonsyndromic hearing loss
BackgroundNonsyndromic autosomal recessive hearing loss (DFNB) is an etiologically heterogeneous disorder group showing a wide spectrum of onset ages...
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Spectral Characteristics of Cardinal Vowels as Indicators of the Auditory Speech Feedback Control in Patients with Moderate and Moderately Severe Chronic Postlingual Sensorineural Hearing Loss
AbstractChronic sensorineural hearing loss (SNHL) is characterized by an increase in hearing thresholds at basic speech frequencies, which implies...
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Apoptotic vesicles resist oxidative damage in noise-induced hearing loss through activation of FOXO3a-SOD2 pathway
BackgroundMesenchymal stem cell (MSC) transplantation is a promising therapeutic approach for noise-induced hearing loss (NIHL). As the indispensable...
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Association between the atherogenic index of plasma and hearing loss based on a nationwide cross-sectional study
BackgroundHearing loss (HL) is a worldwide public health issue for which the role of dyslipidemia has not been fully elucidated. This study aimed to...
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Single-cell RNA-sequencing of zebrafish hair cells reveals novel genes potentially involved in hearing loss
Hair cells play key roles in hearing and balance, and hair cell loss would result in hearing loss or vestibular dysfunction. Cellular and molecular...
