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A study on construction of a prognosis model for liver cancer based on analgesic targets and screening therapeutic drugs
BackgroundLiver cancer is one of the most malignant liver diseases in the world, and the 5-year survival rate of such patients is low. Analgesics are...
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Exploration of interaction interface of TRKβ/BDNF through fingerprint analysis to disinter potential agonists
Tyrosine Kinase beta (TRKβ), is a type I membrane receptor which plays a major role in various signalling pathways. TRKβ was found to be upregulated...
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Effects of poor plumage conditions on egg production, antioxidant status and gene expression in laying hens
The objective of this study was to investigate the effects of poor plumage conditions on production performance, antioxidant status and gene...
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X-linked genes influence various complex traits in dairy cattle
BackgroundThe search for quantitative trait loci (QTL) affecting traits of interest in mammals is frequently limited to autosomes, with the X...
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Pharmacoinformatic Analysis of Drug Leads for Alzheimer’s Disease from FDA-Approved Dataset Through Drug Repositioning Studies
Drug design is highly priced and time-consuming procedure. Therefore, to overcome this problem, in silico drug design methods, particularly drug...
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Study on the mechanism of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen in sedation and tranquillising mind
This study analysed the pharmacological mechanism of Gastrodiae Rhizoma, Lycii Fructus, and Ziziphi Spinosae Semen in sedation and tranquillising...
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The Restorative Effect of Combined Insulin and C-Peptide Intranasal Administration on Hormonal Status and Hypothalamic Signaling in the Male Rat Model of Severe Short-Term Streptozotocin-Induced Diabetes
AbstractAt early stages of severe type 1 diabetes mellitus (DM1), which is characterized by severe insulin deficiency, acute hyperglycemia and...
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Architecture of the subthalamic nucleus
The subthalamic nucleus (STN) is a major neuromodulation target for the alleviation of neurological and neuropsychiatric symptoms using deep brain...
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Large-scale analysis of de novo mutations identifies risk genes for female infertility characterized by oocyte and early embryo defects
BackgroundOocyte maturation arrest and early embryonic arrest are important reproductive phenotypes resulting in female infertility and cause the...
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Generic model to unravel the deeper insights of viral infections: an empirical application of evolutionary graph coloring in computational network biology
PurposeGraph coloring approach has emerged as a valuable problem-solving tool for both theoretical and practical aspects across various scientific...
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Gene count normalization in single-cell imaging-based spatially resolved transcriptomics
BackgroundRecent advances in imaging-based spatially resolved transcriptomics (im-SRT) technologies now enable high-throughput profiling of targeted...
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Biological function and clinical application prospect of tsRNAs in digestive system biology and pathology
tsRNAs are small non-coding RNAs originating from tRNA that play important roles in a variety of physiological activities such as RNA silencing,...
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A porcine brain-wide RNA editing landscape
Adenosine-to-inosine (A-to-I) RNA editing, catalyzed by ADAR enzymes, is an essential post-transcriptional modification. Although hundreds of...
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Spatio-molecular domains identified in the mouse subthalamic nucleus and neighboring glutamatergic and GABAergic brain structures
The subthalamic nucleus (STN) is crucial for normal motor, limbic and associative function. STN dysregulation is correlated with several brain...
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Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1
The DNA methylation status of the X-chromosome in cancer cells is often overlooked because of computational difficulties. Most of the CpG islands on...
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Macrophage plays important role in cortisol and serotonin induced adipogenesis in vitro
Psychological stress is an important cause to induce various metabolic disorders such as obesity, type II diabetes, and cardiovascular disorders by...
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Hindbrain circuits in the control of eating behaviour and energy balance
Body weight and adiposity represent biologically controlled parameters that are influenced by a combination of genetic, developmental and...
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Comprehensive analysis of coding and non-coding RNA transcriptomes related to hypoxic adaptation in Tibetan chickens
BackgroundTibetan chickens, a unique native breed in the Qinghai-Tibet Plateau of China, possess a suite of adaptive features that enable them to...
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Known and Unexplored Post-Translational Modification Pathways in Schizophrenia
Post-translational modifications (PTMs) of proteins occur in all domains of life, affecting various structural and functional properties. Multiple...