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Overexpression of microRNA-100-5p attenuates the endothelial cell dysfunction by targeting HIPK2 under hypoxia and reoxygenation treatment
MicroRNAs (miRNAs) are important regulators of many cellular processes, and the dysregulation of miRNAs is associated with various diseases....
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Exosomal miR-1260b derived from non-small cell lung cancer promotes tumor metastasis through the inhibition of HIPK2
Tumor-derived exosomes (TEXs) contain enriched miRNAs, and exosomal miRNAs can affect tumor growth, including cell proliferation, metastasis, and...
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SPEN induces miR-4652-3p to target HIPK2 in nasopharyngeal carcinoma
SPEN family transcriptional repressor (SPEN), also known as the SMART/HDAC1-associated repressor protein (SHARP), has been reported to modulate the...
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Low glucose metabolite 3-phosphoglycerate switches PHGDH from serine synthesis to p53 activation to control cell fate
Glycolytic intermediary metabolites such as fructose-1,6-bisphosphate can serve as signals, controlling metabolic states beyond energy metabolism....
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Double knock-out of Hmga1 and Hipk2 genes causes perinatal death associated to respiratory distress and thyroid abnormalities in mice
The serine–threonine kinase homeodomain-interacting protein kinase 2 (HIPK2) modulates important cellular functions during development, acting as a...
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Overexpression of homeodomain-interacting protein kinase 2 (HIPK2) attenuates sepsis-mediated liver injury by restoring autophagy
Sepsis is the leading cause of death in intensive care units worldwide. Autophagy has recently been shown to protect against sepsis-induced liver...
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The truncated AXIN1 isoform promotes hepatocellular carcinoma metastasis through SRSF9-mediated exon 9 skip**
Axis inhibitor protein 1 (AXIN1) is a protein recognized for inhibiting tumor growth and is commonly involved in cancer development. In this study,...
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The scaffold protein AXIN1: gene ontology, signal network, and physiological function
AXIN1, has been initially identified as a prominent antagonist within the WNT/β-catenin signaling pathway, and subsequently unveiled its integral...
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SIRT3/6: an amazing challenge and opportunity in the fight against fibrosis and aging
Fibrosis is a typical aging-related pathological process involving almost all organs, including the heart, kidney, liver, lung, and skin....
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Emerging role of tumor suppressor p53 in acute and chronic kidney diseases
p53 is a major regulator of cell cycle arrest, apoptosis, and senescence. While involvement of p53 in tumorigenesis is well established, recent...
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The involvement of E3 ubiquitin ligases in the development and progression of colorectal cancer
To date, colorectal cancer (CRC) still has limited therapeutic efficacy and poor prognosis and there is an urgent need for novel targets to improve...
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MicroRNA-197 induces epithelial–mesenchymal transition and invasion through the downregulation of HIPK2 in lung adenocarcinoma
The major cause of cancer-related deaths in patients with lung adenocarcinoma (LAD) is due to distant metastasis. Many reports have indicated that...
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Programmed Cell Death and its Implications for Skeletal Muscle Wasting
Skeletal muscle atrophy is an inevitable sequel of various factors such as cachexia, aging, fasting, denervation, and microgravity. It is...
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PRCC reduces the sensitivity of cancer cells to DNA damage by inhibiting JNK and ATM/ATR pathways and results in a poor prognosis in hepatocellular carcinoma
Background and aimThe proline rich mitotic checkpoint control factor (PRCC) is involved in the splicing process of pre-mRNA. This study aims to...
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Atg7 autophagy-independent role on governing neural stem cell fate could be potentially applied for regenerative medicine
A literature review showed that Atg7 biological role was associated with the development and pathogenesis of nervous system, but very few reports...
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miRNA regulation of G protein-coupled receptor mediated angiogenic pathways in cancer
Angiogenesis is an important biological process associated with plethora of physiological and patho-physiological conditions. Recent data suggests...
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Autophagy induced by Helicobacter Pylori infection can lead to gastric cancer dormancy, metastasis, and recurrence: new insights
According to the findings of recent research, Helicobacter Pylori ( H. pylori ) infection is not only the primary cause of gastric cancer (GC), but it...
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The cardiac glycoside ZINC253504760 induces parthanatos-type cell death and G2/M arrest via downregulation of MEK1/2 phosphorylation in leukemia cells
Overcoming multidrug resistance (MDR) represents a major obstacle in cancer chemotherapy. Cardiac glycosides (CGs) are efficient in the treatment of...
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SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF
BackgroundThe gene encoding the E3 ubiquitin ligase substrate-binding adapter Speckle-type BTB/POZ protein ( SPOP ) is frequently mutated in prostate...
