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H3K27me3 timely dictates uterine epithelial transcriptome remodeling and thus transformation essential for normal embryo implantation
Uterine luminal epithelia (LE), the first layer contacting with the blastocyst, acquire receptivity for normal embryo implantation. Besides the...
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The EZH2-H3K27me3 axis modulates aberrant transcription and apoptosis in cyclophosphamide-induced ovarian granulosa cell injury
Chemotherapy-induced ovarian damage and infertility are significant concerns for women of childbearing age with cancer; however, the underlying...
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Liquid–liquid phase separation of H3K27me3 reader BP1 regulates transcriptional repression
BackgroundBromo-adjacent homology-plant homeodomain domain containing protein 1 (BP1) is a reader of histone post-translational modifications in...
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JMJD3 regulate H3K27me3 modification via interacting directly with TET1 to affect spermatogonia self-renewal and proliferation
BackgroundIn epigenetic modification, histone modification and DNA methylation coordinate the regulation of spermatogonium. Not only can...
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H3K27me3-H3K4me1 transition at bivalent promoters instructs lineage specification in development
BackgroundBivalent genes, of which promoters are marked by both H3K4me3 (trimethylation of histone H3 on lysine 4) and H3K27me3 (trimethylation of...
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Histone modification landscape and the key significance of H3K27me3 in myocardial ischaemia/reperfusion injury
Histone modifications play crucial roles in the pathogenesis of myocardial ischaemia/reperfusion (I/R) injury. However, a genome-wide map of histone...
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H3K27me3 shapes DNA methylome by inhibiting UHRF1-mediated H3 ubiquitination
DNA methylation and histone lysine tri-methylation at H3K27 (H3K27me3) are two chromatin modifications for transcriptional gene silencing, which play...
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Epigenetic regulation of H3K27me3 in laying hens with fatty liver hemorrhagic syndrome induced by high-energy and low-protein diets
BackgroundFatty liver hemorrhagic syndrome (FLHS) in the modern poultry industry is primarily caused by nutrition. Despite encouraging progress on...
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The EZH2–PRC2–H3K27me3 axis governs the endometrial cell cycle and differentiation for blastocyst invasion
Infertility occurs in 15% of couples worldwide. Recurrent implantation failure (RIF) is one of the major problems in in vitro fertilization and...
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KAKU4 regulates leaf senescence through modulation of H3K27me3 deposition in the Arabidopsis genome
Lamins are the major components of the nuclear lamina, which regulate chromatin structure and gene expression. KAKU4 is a unique nuclear lamina...
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TGF-β1-induced bone marrow mesenchymal stem cells (BMSCs) migration via histone demethylase KDM6B mediated inhibition of methylation marker H3K27me3
Mesenchymal stem cells (MSCs) are widely used in clinical research and therapy. Since the number of MSCs migration is extremely crucial at the lesion...
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CTCF-mediated H3K27me3 enrichment on the LncRNA MALAT1 promoter regulates the cardiomyocytes from I/R-induced apoptosis through targeting miR-26b-5p
BackgroundIt is reported that LncRNAs play an important role in various diseases, including myocardial ischemia–reperfusion injury. However, the...
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Nucleophosmin 1 cooperates with the methyltransferase DOT1L to preserve peri-nucleolar heterochromatin organization by regulating H3K27me3 levels and DNA repeats expression
BackgroundNPM1 is a phosphoprotein highly abundant in the nucleolus. However, additional nuclear functions have been attributed to NPM1, probably...
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Long non-coding RNA FOXP4-AS1 facilitates the biological functions of hepatocellular carcinoma cells via downregulating ZC3H12D by mediating H3K27me3 through recruitment of EZH2
BackgroundSome studies have reported the effect of long non-coding RNA forkhead box P4 antisense RNA 1 (lncRNA FOXP4-AS1) on hepatocellular carcinoma...
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Dynamic Behavior of Inactive X Chromosome Territory During the Cell Cycle as Revealed by H3K27me3-Specific Intracellular Antibody
Posttranslational histone modifications are critical for the regulation of genome function. The levels of histone modifications oscillate during the...
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Seasonal plasticity and diel stability of H3K27me3 in natural fluctuating environments
Diel and seasonal oscillations are two major environmental changes in nature. While organisms cope with the former by the well-characterized...
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KDM6B is an androgen regulated gene and plays oncogenic roles by demethylating H3K27me3 at cyclin D1 promoter in prostate cancer
Lysine (K)-specific demethylase 6B (KDM6B), a stress-inducible H3K27me3 demethylase, plays oncogenic or antitumoral roles in malignant tumors...
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Targeted reprogramming of H3K27me3 resets epigenetic memory in plant paternal chromatin
Epigenetic marks are reprogrammed in the gametes to reset genomic potential in the next generation. In mammals, paternal chromatin is extensively...
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TET3 controls the expression of the H3K27me3 demethylase Kdm6b during neural commitment
The acquisition of cell identity is associated with developmentally regulated changes in the cellular histone methylation signatures. For instance,...
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Fixed Cell Immunofluorescence for Quantification of Hypoxia-Induced Changes in Histone Methylation
Hypoxia and its signalling pathway play a key role in human physiology and a variety of diseases. Alterations in histone methylation coordinate...