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Targeted DNA demethylation of the ZNF334 promoter inhibits colorectal cancer growth
Colorectal cancer (CRC) is a leading cause of cancer deaths worldwide. Aberrant regulation of DNA methylation in promoters of tumor suppressor genes...
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Functional characterization of GhNAC2 promoter conferring hormone- and stress-induced expression: a potential tool to improve growth and stress tolerance in cotton
The GhNAC2 transcription factor identified from G. herbaceum improves root growth and drought tolerance through transcriptional reprogramming of...
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CENPA knockdown restrains cell progression and tumor growth in breast cancer by reducing PLA2R1 promoter methylation and modulating PLA2R1/HHEX axis
BackgroundBreast cancer is a lethal malignancy affecting females worldwide. It has been reported that upregulated centromere protein A (CENPA)...
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Enhancement of recombinant human keratinocyte growth factor 1 protein production in transgenic hazelnut (Corylus avellana L.) plant cell suspension cultures under RAmy3D inducible promoter
Recombinant human KGF1 (rhKGF) is a fibroblast growth factor that promotes epidermal cell proliferation, differentiation, migration, and wound...
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pCtFSG2, a flower-specific promoter with suitable promoter activity in safflower
Safflower ( Carthamus tincorius L.) is an economically important plant. Flowers are a source of dyes and active ingredients in medicines. The...
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Functional analysis of recurrent CDC20 promoter variants in human melanoma
Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can...
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Quantitative Estimation of Promoter Activity in Cannabis sativa Using Agroinfiltration-Based Transient Gene Expression
To properly assess promoter activity, which is critical for understanding biosynthetic pathways in different plant species, we use...
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New pAraDH2 Promoter for Metabolic Engineering of the Yarrowia lipolytica Yeast
AbstractThe ability to utilize a number of polyhydric alcohols as a sole carbon source has been studied in the Yarrowia lipolytica yeast. The...
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Expression of toxic genes in Methylorubrum extorquens with a tightly repressed, cumate-inducible promoter
Methylorubrum extorquens is an important model methylotroph and has enormous potential for the development of C1-based microbial cell factories....
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The overexpression of SlBRI1 driven by Atrd29A promoter-transgenic plants improves the chilling stress tolerance of tomato
Main conclusionOverexpression of SlBRI1 driven by the Atrd29A promoter could increase the cold resistance of tomato plants during chilling stress but...
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Chitosan nanoparticles as a rice growth promoter: evaluation of biological activity
The agriculture sector is the building block of an economy with more than 60% of the world population depending on it for livelihood. Among the many...
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Identification of a sugarcane bacilliform virus promoter that is activated by drought stress in plants
Sugarcane ( Saccharum spp.) is an important sugar and biofuel crop in the world. It is frequently subjected to drought stress, thus causing...
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Association of insulin-like growth factor binding protein-7 promoter methylation with esophageal cancer in peripheral blood
BackgroundThe insulin-like growth factor (IGF) signaling pathway has an important role in many cancers, including esophageal cancer (EC). IGF-binding...
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An efficient CRISPR–Cas12a promoter editing system for crop improvement
Promoter editing represents an innovative approach to introduce quantitative trait variation (QTV) in crops. However, an efficient promoter editing...
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Nutrient limitation and oxidative stress induce the promoter of acetate operon in Salmonella Typhimurium
Glyoxylate shunt is an important pathway for microorganisms to survive under multiple stresses. One of its enzymes, malate synthase (encoded by aceB ...
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Iron-manganese nanocomposites doped graphene quantum dots as growth promoter of wheat and its biomimetic activity
This study describes the development of iron manganese doped graphene quantum dots (FeMnO 4 @GQD) having peroxidase-like catalytic activity detected...
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Use of the Saccharomycopsis schoenii MET17 promoter for regulated heterologous gene expression
The ability to regulate the expression of genes is a central tool for the characterization of fungal genes. This is of particular interest to study...
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Identification and promoter analysis of a GA-stimulated transcript 1 gene from Jatropha curcas
Key messageOverexpression of JcGAST1 promotes plant growth but inhibits pistil development. The pyrimidine box and CGTCA motif of the JcGAST1 ...
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Develo** a CRISPR/FrCas9 system for core promoter editing in rice
Small mutations in the core promoter region of a gene may result in substantial changes in expression strengths. However, targeting TA-rich sequences...
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DNA methyltransferase 3a-induced hypermethylation of the fructose-1,6-bisphosphatase-2 promoter contributes to gastric carcinogenesis
BackgroundAberrant DNA methylation has been implicated in the development of gastric cancer (GC). In our previous study, we demonstrated that...
