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Embryogenesis, Growth, and Differentiation
An essential feature of plant development is the ability of plant cells to grow and differentiate. Growth of an organism is defined as an...
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PLCβ1 by-passes early growth response -1 to induce the differentiation of neuronal cells
The Gα q /phospholipase C-β (PLCβ) signaling system mediates calcium responses to a variety of hormones and neurotransmitters. Recent studies suggest...
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Bovine Skeletal Muscle Satellite Cells: Isolation, Growth, and Differentiation
Skeletal muscle in cattle occupies a large part of the animal’s body mass and develops into an important source of nutrients for human nutrition....
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Simulated lunar microgravity transiently arrests growth and induces osteocyte-chondrocyte lineage differentiation in human Wharton’s jelly stem cells
Human Wharton’s jelly stem cells (hWJSCs) are multipotent stem cells that are extensively employed in biotechnology applications. However, the impact...
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mTORC1 signaling pathway integrates estrogen and growth factor to coordinate vaginal epithelial cells proliferation and differentiation
The mouse vaginal epithelium cyclically exhibits cell proliferation and differentiation in response to estrogen. Estrogen acts as an activator of...
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Growth differentiation factor 7 autocrine signaling promotes hepatic progenitor cell expansion in liver fibrosis
Background and aimLiver fibrosis is prevalent among chronic diseases of the liver and represents a major health burden worldwide. Growth...
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How the mechanical microenvironment of stem cell growth affects their differentiation: a review
Stem cell differentiation is of great interest in medical research; however, specifically and effectively regulating stem cell differentiation is...
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Growth differentiation factor 5 inhibits lipopolysaccharide-mediated pyroptosis of nucleus pulposus mesenchymal stem cells via RhoA signaling pathway
BackgroundDegenerative disc disease(DDD)is one of the most important causes of low back pain (LBP). Programmed death of human nucleus pulposus...
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Enhancing cord blood stem cell-derived NK cell growth and differentiation through hyperosmosis
BackgroundNatural killer (NK) cells hold great promise in treating diverse hematopoietic and solid tumors. Despite their availability from peripheral...
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Basic Fibroblast Growth Factor Induces Cholinergic Differentiation of Tonsil-Derived Mesenchymal Stem Cells
Background:Mesenchymal stem cells (MSCs) are considered a potential tool for regenerating damaged tissues due to their great multipotency into...
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An insight into differential protein abundance throughout Leishmania donovani promastigote growth and differentiation
Leishmania donovani causes anthroponotic visceral leishmaniasis, responsible for about 50,000 annual deaths worldwide. Current therapies have...
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The H3K27M mutation alters stem cell growth, epigenetic regulation, and differentiation potential
BackgroundNeurodevelopmental disorders increase brain tumor risk, suggesting that normal brain development may have protective properties. Mutations...
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Chondrogenic Differentiation of Human-Induced Pluripotent Stem Cells
The generation of large quantities of genetically defined human chondrocytes remains a critical step for the development of tissue engineering...
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p66Shc signaling and autophagy impact on C2C12 myoblast differentiation during senescence
During aging, muscle regenerative capacities decline, which is concomitant with the loss of satellite cells that enter in a state of irreversible...
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Visualizing Activated Myofibroblasts Resulting from Differentiation of Mesenchymal Stem Cells
Mesenchymal stem cells (MSCs) are multipotent cells that exhibit two main characteristics which define stem cells: self-renewal and differentiation....
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Signaling Pathways in Trans-differentiation of Mesenchymal Stem Cells: Recent Advances
Mesenchymal stem cells are a group of multipotent cells that can be induced to differentiate into other cell types. The cells fate is decided by...
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TGF-β signaling regulates differentiation of MSCs in bone metabolism: disputes among viewpoints
Mesenchymal stem cells (MSCs) are multipotent cells that can differentiate into cells of different lineages to form mesenchymal tissues, which are...
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Less Frequently Used Growth Regulators in Plant Tissue Culture
Plant growth regulators are routinely added to in vitro culture media to foster the growth and differentiation of the cells, tissues, and organs....
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Growth differentiation factor 11 induces skeletal muscle atrophy via a STAT3-dependent mechanism in pulmonary arterial hypertension
Skeletal muscle wasting is a clinically remarkable phenotypic feature of pulmonary arterial hypertension (PAH) that increases the risk of mortality....
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The role of semaphorin 3A on chondrogenic differentiation
Osteoblast-derived semaphorin3A (Sema3A) has been reported to be involved in bone protection, and Sema3A knockout mice have been reported to exhibit...
