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H3K9 and H4K20 methyltransferases are directly involved in the heterochromatinization of the paternal chromosomes in male Planococcus citri embryos
Using a new method for bulk preparation of early stage embryos, we have investigated the role played by putative Planococcus citri H3K9 and H4K20...
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From in vivo to in vitro: exploring the key molecular and cellular aspects of human female gametogenesis
Human oogenesis is a highly complex and not yet fully understood process due to ethical and technological barriers that limit studies in the field....
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Genomic Imprinting
A typical cell contains two sets of chromosomes: one that was inherited from the mother, the other from the father. Usually, autosomal alleles are...
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Genomic Imprinting: A Paradigm for Epigenetics of Human Diseases
Genomic imprinting is a remarkable phenomenon through which certain genes show monoallelic expression depending on their parent of origin. While...
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Whole-genome resequencing reveals loci with allelic transmission ratio distortion in F1 chicken population
Allelic transmission ratio distortion (TRD) is the significant deviation from the expected ratio under Mendelian inheritance theory, which may be...
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Inheritance of perturbed methylation and metabolism caused by uterine malnutrition via oocytes
BackgroundUndernourishment in utero has deleterious effects on the metabolism of offspring, but the mechanism of the transgenerational transmission...
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Bend family proteins mark chromatin boundaries and synergistically promote early germ cell differentiation
Understanding the regulatory networks for germ cell fate specification is necessary to develo** strategies for improving the efficiency of germ...
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Single-cell RNA sequencing of mitotic-arrested prospermatogonia with DAZL::GFP chickens and revealing unique epigenetic reprogramming of chickens
BackgroundGerm cell mitotic arrest is conserved in many vertebrates, including birds, although the time of entry or exit into quiescence phase...
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Profiling DNA Methylation in Human Naïve Pluripotent Stem Cells
DNA methylation represents one of the best characterized epigenetic modifications. In particular, global demethylation is a common feature of...
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Epigenetic Inheritance
The field of epigenetics, orchestrating molecular communication at the genome-phenotype interface, has gained significant importance over the last...
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Casting histone variants during mammalian reproduction
During mammalian reproduction, germ cell chromatin packaging is key to prepare parental genomes for fertilization and to initiate embryonic...
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Genetic Studies on Mammalian DNA Methyltransferases
Cytosine methylation at the C5-position—generating 5-methylcytosine (5mC)—is a DNA modification found in many eukaryotic organisms, including fungi,...
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Epigenetic Regulation Disturbances on Gene Expression in Imprinting Diseases
Abstract—Epigenetic regulation is hereditary and non-hereditary changes in the expression of a particular gene without any corresponding structural...
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Clonal origin of KMT2A wild-type lineage-switch leukemia following CAR-T cell and blinatumomab therapy
Children with acute lymphoblastic leukemia (ALL) undergoing anti-CD19 therapy occasionally develop acute myeloid leukemia (AML). The clonal origin of...
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Epigenetics and DNA Methylation
Epigenetics is a wide term representing molecular processes leading to modification of gene expression without bringing any DNA base sequence...
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Epigenetics in Development
Epigenetic processes regulate cellular function at all stages of life. Epigenetic processes in their entirety are referred to as the epigenome, which...
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Non-Mendelian segregation and transmission drive of B chromosomes
Selfish genetic elements (SGE) get a transmission advantage (drive) thanks to their non-Mendelian inheritance. Here I identify eight steps during the...
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The conserved DNMT1-dependent methylation regions in human cells are vulnerable to neurotoxicant rotenone exposure
BackgroundAllele-specific DNA methylation (ASM) describes genomic loci that maintain CpG methylation at only one inherited allele rather than having...
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Reduced PRC2 function alters male germline epigenetic programming and paternal inheritance
BackgroundDefining the mechanisms that establish and regulate the transmission of epigenetic information from parent to offspring is critical for...
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Conservation and divergence of canonical and non-canonical imprinting in murids
BackgroundGenomic imprinting affects gene expression in a parent-of-origin manner and has a profound impact on complex traits including growth and...
