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A quantitative method to measure geranylgeranyl diphosphate (GGPP) and geranylgeranyl monophosphate (GGP) in tomato (Solanum lycopersicum) fruit
BackgroundIsoprenoids are a very large class of metabolites playing a key role in plant physiological processes such as growth, stress resistance,...
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Identification and functional characterization of two trans-isopentenyl diphosphate synthases and one squalene synthase involved in triterpenoid biosynthesis in Platycodon grandiflorus
Main conclusionTwo trans -isopentenyl diphosphate synthase and one squalene synthase genes were identified and proved to be involved in the...
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Genome-wide identification of the geranylgeranyl pyrophosphate synthase (GGPS) gene family involved in chlorophyll synthesis in cotton
BackgroundGeranylgeranyl pyrophosphate synthase (GGPS) is a structural enzyme of the terpene biosynthesis pathway that is involved in regulating...
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Therapeutic targeting of the mevalonate–geranylgeranyl diphosphate pathway with statins overcomes chemotherapy resistance in small cell lung cancer
Small cell lung cancer (SCLC) lacks effective treatments to overcome chemoresistance. Here we established multiple human chemoresistant xenograft...
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Plant geranylgeranyl diphosphate synthases: every (gene) family has a story
Plant isoprenoids (also known as terpenes or terpenoids) are a wide family of primary and secondary metabolites with multiple functions. In...
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Cloning and homologous characterization of geranylgeranyl pyrophosphate synthase (GGPPS) from Withania somnifera revealed alterations in metabolic flux towards gibberellic acid biosynthesis
Main conclusionOverexpression of a novel geranylgeranyl pyrophosphate synthase gene ( WsGGPPS) in planta resulted in increased levels of gibberellic...
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Unraveling the multiplicity of geranylgeranyl reductases in Archaea: potential roles in saturation of terpenoids
The enzymology of the key steps in the archaeal phospholipid biosynthetic pathway has been elucidated in recent years. In contrast, the complete...
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Genome-wide characterization and expression analysis of geranylgeranyl diphosphate synthase genes in cotton (Gossypium spp.) in plant development and abiotic stresses
BackgroundGGPP (geranylgeranyl diphosphate) is produced in the isoprenoid pathway and mediates the function of various plant metabolites, which is...
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Regulation of the Notch-ATM-abl axis by geranylgeranyl diphosphate synthase inhibition
Notch proteins drive oncogenesis of many cancers, most prominently T-cell acute lymphoblastic leukemia (T-ALL). Because geranylgeranylated Rab...
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Analysis of root volatiles and functional characterization of a root-specific germacrene A synthase in Artemisia pallens
Main conclusionThe study demonstrated that
Artemisia pallens roots can be a source of terpene-rich essential oil and root-specific ApTPS1 forms...
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A Simple In Vitro Assay to Measure the Activity of Geranylgeranyl Diphosphate Synthase and Other Short-Chain Prenyltransferases
Most carotenoids are C40 metabolites produced from C20 geranylgeranyl diphosphate (GGPP). The enzymes that produce this precursor, GGPP synthases...
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Characterization of regioisomeric diterpenoid tails in bacteriochlorophylls produced by geranylgeranyl reductase from Halorhodospira halochloris and Blastochloris viridis
Geranylgeranyl reductase (GGR) encoded by the bchP gene catalyzes the reductions of three unsaturated C = C double bonds (C6 = C7, C10 = C11, and...
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Characterization of sandalwood (E,E)-α-farnesene synthase whose overexpression enhances cold tolerance through jasmonic acid biosynthesis and signaling in Arabidopsis
Main conclusionSantalum album (E,E )-α-farnesene synthase catalyzes FPP into (E,E )-α-farnesene. Overexpression of theSaAFS gene positively improved...
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Promoter characterization of a citrus linalool synthase gene mediating interspecific variation in resistance to a bacterial pathogen
BackgroundTerpenoids play essential roles in plant defense against biotic stresses. In Citrus species, the monoterpene linalool mediates resistance...
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Transcriptomic Analysis Reveals Suppression of Photosynthesis and Chlorophyll Synthesis Following Gibberellic Acid Treatment on Oil Palm (Elaies guineensis)
Gibberellins (GA) and paclobutrazol (PBZ) are plant growth regulators. GA promotes plant growth and development while PBZ retards plant growth....
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Transcriptional responses of hypericin and hyperforin to methyl jasmonate elicitation in Hypericum perforatum
Hypericin and hyperforin are the most important secondary metabolites of Hypericum perforatum , which are fundamentally effective and useful in...
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Metabolic engineering of Bacillus subtilis toward the efficient and stable production of C30-carotenoids
Commercial carotenoid production is dominated by chemical synthesis and plant extraction, both of which are unsustainable and can be detrimental to...
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Integrative transcriptome analysis uncovers common components containing CPS2 regulated by maize lncRNA GARR2 in gibberellin response
Main conclusionThe combined transcriptome outcome provides an important clue to the regulatory cascade centering on lncRNA GARR2 and CPS2 gene in GA...
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Transcript expression level analysis of phytoene synthase and phytoene desaturase associated with β-carotene content in selected Kenyan Bitter melon
BackgroundBitter melon ( Momordica charantia L. ) is a widely cultivated food and medicinal plant native to the world's subtropics and tropics....
