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Genomic Instability
Maintenance of genome stability is vital for human health, and it is of particular importance in ageing. Genome stability is regulated by multiple...
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Genomic distribution and context dependent functionality of novel WRKY transcription factor binding sites
BackgroundThe WT-boxes NGACTTTN are novel microbe-associated molecular pattern (MAMP)-responsive cis -regulatory sequences. Many of them are uncommon...
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ALAN is a computational approach that interprets genomic findings in the context of tumor ecosystems
Gene behavior is governed by activity of other genes in an ecosystem as well as context-specific cues including cell type, microenvironment, and...
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Principles of Genomic Evolution
In the preceding chapters, we looked at a possible topological model of genomic architecture. Even if we were to accept the proposed model to be true...
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Improving Bacterial sRNA Identification By Combining Genomic Context and Sequence-Derived Features
Bacterial small non-coding RNAs (sRNAs) are ubiquitous regulatory RNAs involved in controlling several cellular processes by targeting multiple...
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Genomic Selection in Crop Improvement
A boost in the crop improvement rate is essential for accomplishing a sustainable food supply and other demands of rapid population growth. Genomic...
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Optimization of Multi-Generation Multi-location Genomic Prediction Models for Recurrent Genomic Selection in an Upland Rice Population
Genomic selection is a worthy breeding method to improve genetic gain in recurrent selection breeding schemes. The integration of multi-generation...
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Nature of Aging Processes: Genomic Ontology of Aging
The process of aging, like the embryonic development, must be seen as a polygenic phenomenon embedded at a deeper level of the genomic architecture....
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Bayesian discrete lognormal regression model for genomic prediction
Key messageGenomic prediction models for quantitative traits assume continuous and normally distributed phenotypes. In this research, we proposed a...
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Genomic Islands Involved in Iron Uptake
Iron is an important element for all life forms. In microbial life, it plays a significant bearing either as an important growth factor and/or...
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Genomic Selection in Maize Breeding
Rapid developments in the field of genomics have benefitted plant breeding in recent times. Genomic selection (GS) is one of the tools hel** plant...
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Accelerating Almond Breeding in Post-genomic Era
Classical almond breeding is a long process due to its plurennial woody character and long juvenile period. The implementation of marker-assisted...
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Best practices for genetic and genomic data archiving
Genetic and genomic data are collected for a vast array of scientific and applied purposes. Despite mandates for public archiving, data are typically...
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Disease-driven top predator decline affects mesopredator population genomic structure
Top predator declines are pervasive and often have dramatic effects on ecological communities via changes in food web dynamics, but their...
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Genomic diversity of the pathogenic fungus Aspergillus fumigatus in Japan reveals the complex genomic basis of azole resistance
Aspergillus fumigatus is a pathogenic fungus with a global distribution. The emergence of azole-resistant A. fumigatus (AR Af ) other than the...
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Nature of Genomic Architecture: A Topological Model of Genome
Our present understanding of genomic architecture is based on incremental addition of the manner in which genes are expressed. At present, there is...
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Genomic data integration tutorial, a plant case study
BackgroundThe ongoing evolution of the Next Generation Sequencing (NGS) technologies has led to the production of genomic data on a massive scale....
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Microbial Genomic Island Discovery: Visualization and Analysis
Genomic Islands (GIs), the integrative part of the prokaryotic genomes which contain many genes with important biological functions. The islands are...
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Aneuploidy and complex genomic rearrangements in cancer evolution
Mutational processes that alter large genomic regions occur frequently in develo** tumors. They range from simple copy number gains and losses to...
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Nature of Genomic Evolution: Its Imprint in Cancer
In preceding chapters, a topological model of the genomic architecture is described. This model is characterized by top to bottom control elements...