Search
Search Results
-
Recombination and Chromosomal Rearrangements
Maintenance of chromosome stability is essential for the survival of all organisms and the transmission of their genetic information. Chromosomes...
-
Genome Rearrangement Analysis
Genome rearrangements are mutations that change the gene content of a genome or the arrangement of the genes on a genome. Several years of research...
-
Rapid detection of mutations and chromosomal rearrangements in T-DNA insertion mutants of Colletotrichum higginsianum using long-read whole-genome sequencing
Random mutagenesis is a useful tool for identifying genes of interest. Here, we used long-read whole-genome sequencing analysis to identify T-DNA...
-
Gene rearrangements in the mitochondrial genome of Eucleoteuthis luminosa (Ommastrephidae, Cephalopoda) and phylogenetic implications for Coleoidea
The complete mitochondrial genome provides crucial information for comprehending gene rearrangement, molecular evolution, and phylogenetic analysis....
-
High-density linkage maps and chromosome level genome assemblies unveil direction and frequency of extensive structural rearrangements in wood white butterflies (Leptidea spp.)
Karyotypes are generally conserved between closely related species and large chromosome rearrangements typically have negative fitness consequences...
-
The pan-genome of Mycobacterium avium subsp. paratuberculosis (Map) confirms ancestral lineage and reveals gene rearrangements within Map Type S
BackgroundTo date genomic studies on Map have concentrated on Type C strains with only a few Type S strains included for comparison. In this study...
-
High rates of structural rearrangements have shaped the chromosome evolution in dysploid Phaseolus beans
Key messageKaryotypes evolve through numerical and structural chromosome rearrangements. We show that Phaseolus leptostachyus , a wild bean,...
-
From germline genome to highly fragmented somatic genome: genome-wide DNA rearrangement during the sexual process in ciliated protists
Genomes are incredibly dynamic within diverse eukaryotes and programmed genome rearrangements (PGR) play important roles in generating genomic...
-
Fold-back mechanism originating inv-dup-del rearrangements in chromosomes 13 and 15
Intrachromosomal rearrangements involve a single chromosome and can be formed by several proposed mechanisms. We reported two patients with...
-
Co-localization of clusters of TCR-regulated genes with TAD rearrangements
BackgroundGene expression has long been known to be influenced by the relative proximity of DNA regulatory elements. Topologically associating...
-
Family-Free Genome Comparison
The comparison of large-scale genome structures across distinct species offers valuable insights into the species’ phylogeny, genome organization,...
-
DNA polymerases in precise and predictable CRISPR/Cas9-mediated chromosomal rearrangements
BackgroundRecent studies have shown that, owning to its cohesive cleavage, Cas9-mediated CRISPR gene editing outcomes at junctions of chromosomal...
-
Comparative Genome Annotation
Newly sequenced genomes are being added to the tree of life at an unprecedented fast pace. A large proportion of such new genomes are...
-
Translocations and inversions: major chromosomal rearrangements during Vigna (Leguminosae) evolution
Key messageInversions and translocations are the major chromosomal rearrangements involved in Vigna subgenera evolution, being Vigna vexillata the...
-
LDLR gene rearrangements in Czech FH patients likely arise from one mutational event
BackgroundLarge deletions and duplications within the low-density lipoprotein receptor ( LDLR) gene make up approximately 10% of LDLR pathogenic...
-
MSV: a modular structural variant caller that reveals nested and complex rearrangements by unifying breakends inferred directly from reads
Structural variant (SV) calling belongs to the standard tools of modern bioinformatics for identifying and describing alterations in genomes....
-
A Cre-LoxP-based approach for combinatorial chromosome rearrangements in human HAP1 cells
Alterations of human karyotype caused by chromosomal rearrangements are often associated with considerable phenotypic effects. Studying molecular...
-
Efficient gene orthology inference via large-scale rearrangements
BackgroundRecently we developed a gene orthology inference tool based on genome rearrangements ( Journal of Bioinformatics and Computational Biology ...
-
Rapid Detection of Transposon-Induced Genome Rearrangements
This chapter details the techniques used to detect transposon-induced genome rearrangements. Here, we describe a rapid DNA isolation technique, PCR...