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Genetic and Molecular Quality Control of Genetically Engineered Mice
Genetically engineered mice are used as avatars to understand mammalian gene function and develop therapies for human disease. During genetic...
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Genetically Engineered Hamster Models of Dyslipidemia and Atherosclerosis
Animal models of human diseases play an extremely important role in biomedical research. Among them, mice are widely used animal models for...
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Dual engineered bacteria improve inflammatory bowel disease in mice
AbstractCurrently, there are many different therapies available for inflammatory bowel disease (IBD), including engineered live bacterial...
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Simulation of COVID-19 symptoms in a genetically engineered mouse model: implications for the long haulers
The ongoing pandemic (also known as coronavirus disease-19; COVID-19) by a constantly emerging viral agent commonly referred as the severe acute...
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Breeding of Genetically Engineered Indonesian Potato, Bio Granola, Resistant to Late Blight Pathogen Phytophthora infestans
As a staple food in many regions in the world, potatoes are the world’s fourth most consumed food. In Indonesia, potatoes contribute significantly to...
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Genetically modified mice as a tool for the study of human diseases
Modeling a human disease is an essential part of biomedical research. The recent advances in the field of molecular genetics made it possible to...
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Engineered probiotic overcomes pathogen defences using signal interference and antibiotic production to treat infection in mice
Probiotic supplements are suggested to promote human health by preventing pathogen colonization. However, the mechanistic bases for their efficacy in...
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The immunobiology and clinical use of genetically engineered porcine hearts for cardiac xenotransplantation
A summary of the scientific rationale of the advancements that led to the first genetically modified pig-to-human cardiac xenotransplantation is...
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Genetically Engineered CLDN18.2 CAR-T Cells Expressing Synthetic PD1/CD28 Fusion Receptors Produced Using a Lentiviral Vector
This study aimed to develop synthetic Claudin18.2 (CLDN18.2) chimeric antigen receptor (CAR)-T (CAR-T) cells as a treatment for advanced gastric...
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Designing Genetically Engineered Mouse Models (GEMMs) Using CRISPR Mediated Genome Editing
Genetically engineered mouse models (GEMMs) are very powerful tools to study lineage hierarchy and cellular dynamics of stem cells in vivo. Stem cell...
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Anti-inflammatory, Anti-fibrotic and Pro-cardiomyogenic Effects of Genetically Engineered Extracellular Vesicles Enriched in miR-1 and miR-199a on Human Cardiac Fibroblasts
RationaleEmerging evidence indicates that stem cell (SC)- derived extracellular vesicles (EVs) carrying bioactive miRNAs are able to repair damaged...
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Genetically encoded phosphatidylserine biosensor for in vitro, ex vivo and in vivo labelling
BackgroundThe dynamics of phosphatidylserine in the plasma membrane is a tightly regulated feature of eukaryotic cells. Phosphatidylserine (PS) is...
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Delivery of a sebum modulator by an engineered skin microbe in mice
Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most...
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Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression
The development of transgenic mouse models that express genes of interest in specific cell types has transformed our understanding of basic biology...
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Lessons learned from the introduction of genetically engineered crops: relevance to gene drive deployment in Africa
The application of gene drives to achieve public health goals, such as the suppression of Anopheles gambiae populations, or altering their ability to...
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Donor template delivery by recombinant adeno-associated virus for the production of knock-in mice
BackgroundThe ability of recombinant adeno-associated virus to transduce preimplantation mouse embryos has led to the use of this delivery method for...
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Recent advances in single-cell engineered live biotherapeutic products research for skin repair and disease treatment
The human microbiome has emerged as a key player in maintaining skin health, and dysbiosis has been linked to various skin disorders. Amidst growing...
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Engineered poly(A)-surrogates for translational regulation and therapeutic biocomputation in mammalian cells
Here, we present a gene regulation strategy enabling programmable control over eukaryotic translational initiation. By excising the natural...
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Engineered live bacteria suppress Pseudomonas aeruginosa infection in mouse lung and dissolve endotracheal-tube biofilms
Engineered live bacteria could provide a new modality for treating lung infections, a major cause of mortality worldwide. In the present study, we...
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Compositional changes in fecal microbiota in a new Parkinson's disease model: C57BL/6-Tg(NSE-haSyn) mice
BackgroundThe gut–brain axis (GBA) in Parkinson's disease (PD) has only been investigated in limited mice models despite dysbiosis of the gut...
