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Genetic map** of the wheat leaf rust resistance gene Lr19 and development of translocation lines to break its linkage with yellow pigment
Key messageThe leaf rust resistance gene Lr19 , which is present on the long arm of chromosome 7E1 in Thinopyrum ponticum , was mapped within a 0.3-cM...
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Viruses and autophagy: bend, but don’t break
Autophagy is a constitutive cellular process of degradation required to maintain homeostasis and turn over spent organelles and aggregated proteins....
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SSBlazer: a genome-wide nucleotide-resolution model for predicting single-strand break sites
Single-strand breaks are the major DNA damage in the genome and serve a crucial role in various biological processes. To reveal the significance of...
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A comparative proteomic analysis provides insight into the molecular mechanism of bud break in longan
BackgroundThe timing of bud break is very important for the flowering and fruiting of longan. To obtain new insights into the underlying regulatory...
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Di- and tri-methylation of histone H3K36 play distinct roles in DNA double-strand break repair
Histone H3 Lys36 (H3K36) methylation and its associated modifiers are crucial for DNA double-strand break (DSB) repair, but the mechanism governing...
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Linking CRISPR–Cas9 double-strand break profiles to gene editing precision with BreakTag
Cas9 can cleave DNA in both blunt and staggered configurations, resulting in distinct editing outcomes, but what dictates the type of Cas9 incisions...
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Genetic Studies on Behavior
Animal behavior is one of the most complex phenomena in biology. Understanding the cellular and molecular basis of behavior is one of the critical...
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Fatty acid oxidation facilitates DNA double-strand break repair by promoting PARP1 acetylation
DNA repair is a tightly coordinated stress response to DNA damage, which is critical for preserving genome integrity. Accruing evidence suggests that...
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Wheat Genetic Resources
In order to continue humanity, we need to feed the growing population and practice agriculture in harmony with the changing environmental conditions....
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Time-resolved microfluidics unravels individual cellular fates during double-strand break repair
BackgroundDouble-strand break repair (DSBR) is a highly regulated process involving dozens of proteins acting in a defined order to repair a DNA...
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Boric Acid Alters the Expression of DNA Double Break Repair Genes in MCF-7-Derived Breast Cancer Stem Cells
Breast cancer pathology ranks second in mortality among women worldwide due to the resistance of cancer stem cells in tumor tissue to radiotherapy...
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DEtail-seq is an ultra-efficient and convenient method for meiotic DNA break profiling in multiple organisms
Programmed DNA double-strand break (DSB) formation is a crucial step in meiotic recombination, yet techniques for high-efficiency and precise map**...
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Comprehensive analysis and expression profiles of the AP2/ERF gene family during spring bud break in tea plant (Camellia sinensis)
BackgroundAP2/ERF transcription factors (AP2/ERFs) are important regulators of plant physiological and biochemical metabolism. Evidence suggests that...
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Meiotic pairing and double-strand break formation along the heteromorphic threespine stickleback sex chromosomes
Double-strand break repair during meiosis is normally achieved using the homologous chromosome as a repair template. Heteromorphic sex chromosomes...
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Genetic Improvement of Banana
Banana (Musa spp.) stands as one of the most important staple crops globally, catering to both food security and economic livelihoods in numerous...
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Boric Acid Affects the Expression of DNA Double-Strand Break Repair Factors in A549 Cells and A549 Cancer Stem Cells: An In Vitro Study
DNA double-strand break (DSB) repair genes interact with tumor stemness- and resistance-associated processes in cancer stem cells (CSCs). Therefore,...
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Deletion of IRC19 Causes Defects in DNA Double-Strand Break Repair Pathways in Saccharomyces cerevisiae
DNA double-strand break (DSB) repair is a fundamental cellular process crucial for maintaining genome stability, with homologous recombination and...
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Expression of human BRCA2 in Saccharomyces cerevisiae complements the loss of RAD52 in double-strand break repair
BRCA2 is a tumor-suppressor gene that is normally expressed in the breast and ovarian tissue of mammals. The BRCA2 protein mediates the repair of...
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DNA double-strand break–capturing nuclear envelope tubules drive DNA repair
Current models suggest that DNA double-strand breaks (DSBs) can move to the nuclear periphery for repair. It is unclear to what extent human DSBs...
