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A common gene signature of the right ventricle in failing rat and human hearts
The molecular mechanisms of progressive right heart failure are incompletely understood. In this study, we systematically examined transcriptomic...
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A robust immune-related gene pairs signature for predicting the overall survival of esophageal cancer
BackgroundIdentifying reliable biomarkers could effectively predict esophagus carcinoma (EC) patients with poor prognosis. In this work, we...
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Construction of immune-related gene pairs signature to predict the overall survival of multiple myeloma patients based on whole bone marrow gene expression profiling
Multiple myeloma (MM) is a plasma cell dyscrasia that is characterized by the uncontrolled proliferation of malignant PCs in the bone marrow. Due to...
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Identification and validation of a novel nine-gene prognostic signature of stem cell characteristic in hepatocellular carcinoma
Currently, cancer stem cells (CSCs) are regarded as the most promising target for cancer therapy due to their close association with tumor...
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A lipid metabolism-related gene signature reveals dynamic immune infiltration of the colorectal adenoma-carcinoma sequence
BackgroundLipid metabolism-related genes (LMRGs) have been reported to be correlated with the immune infiltration of colorectal cancer (CRC). This...
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Exploration and validation of a combined Hypoxia and m6A/m5C/m1A regulated gene signature for prognosis prediction of liver cancer
BackgroundIt is widely acknowledged that hypoxia and m6A/m5C/m1A RNA modifications promote the occurrence and development of tumors by regulating the...
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Development and validation of an RBP gene signature for prognosis prediction in colorectal cancer based on WGCNA
BackgroundRNA binding proteins (RBPs) have been implicated in oncogenesis and progression in various cancers. However, the potential value of RBPs as...
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Towards a potential pan-cancer prognostic signature for gene expression based on probesets and ensemble machine learning
Cancer is one of the leading causes of death worldwide and can be caused by environmental aspects (for example, exposure to asbestos), by human...
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Development and experimental validation of a folate metabolism-related gene signature to predict the prognosis and immunotherapeutic sensitivity in bladder cancer
Folate metabolism is critical for the maintenance of genomic stability due to its regulatory ability to methylation, nucleotide metabolism, and...
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Identification and validation of an ECM organization-related gene signature as a prognostic biomarker and therapeutic target for glioma patients
BackgroundGlioma is the most common and devastating form of malignant brain tumor, with a poor prognosis. Extracellular matrix (ECM) organization is...
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Novel six-gene prognostic signature based on colon adenocarcinoma immune-related genes
BackgroundColon adenocarcinoma (COAD) is one of the most common gastrointestinal tumors worldwide, and immunotherapy is one of the most promising...
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Development of a 32-gene signature using machine learning for accurate prediction of inflammatory bowel disease
Inflammatory bowel disease (IBD) is a chronic inflammatory condition caused by multiple genetic and environmental factors. Numerous genes are...
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Identification and validation of an m6A-related gene signature to predict prognosis and evaluate immune features of breast cancer
Breast cancer is the most prevalent cancer, and it is accompanied by high heterogeneity. N6-methyladenosine (m6A) modification significantly...
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Novel Gene Signature for Bladder Cancer Stage Identification
This article presents a study that aimed to identify the stages of bladder cancer based on gene expression data. The dataset used in the study was...
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A novel mitochondria-related gene signature in esophageal carcinoma: prognostic, immune, and therapeutic features
Esophageal carcinoma (ESCA) is a common and lethal malignant tumor worldwide. The mitochondrial biomarkers were useful in finding significant...
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Construction and validation of a cuproptosis-related diagnostic gene signature for atrial fibrillation based on ensemble learning
BackgroundAtrial fibrillation (AF) is the most common type of cardiac arrhythmia. Nonetheless, the accurate diagnosis of this condition continues to...
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Discovery of a novel lipid metabolism-related gene signature to predict outcomes and the tumor immune microenvironment in gastric cancer by integrated analysis of single-cell and bulk RNA sequencing
Gastric cancer (GC) is a pressing global clinical issue, with few treatment options and a poor prognosis. The onset and spread of stomach cancer are...
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Characterization of a lipid droplet and endoplasmic reticulum stress related gene risk signature to evaluate the clinical and biological value in hepatocellular carcinoma
IntroductionLipid metabolism and endoplasmic reticulum (ER) stress play an important role in the progression and metastasis of hepatocellular...
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Comprehensive analyses of a CD8+ T cell infiltration related gene signature with regard to the prediction of prognosis and immunotherapy response in lung squamous cell carcinoma
Lung squamous cell carcinoma (LUSC) is associated with a worse prognosis than other histological subtypes of non-small cell lung cancer. Due to the...
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Evolution of gene expression signature in mammary gland stem cells from neonatal to old mice
During the lifetime of females, mammary epithelial cells undergo cyclical expansion and proliferation depending on the cyclical activation of mammary...
