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Gene panel selection for targeted spatial transcriptomics
Targeted spatial transcriptomics hold particular promise in analyzing complex tissues. Most such methods, however, measure only a limited panel of...
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Detecting signatures of selection on gene expression
A substantial amount of phenotypic diversity results from changes in gene expression levels and patterns. Understanding how the transcriptome evolves...
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SRGS: sparse partial least squares-based recursive gene selection for gene regulatory network inference
BackgroundThe identification of gene regulatory networks (GRNs) facilitates the understanding of the underlying molecular mechanism of various...
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Unusual Dependence between Gene Expression and Negative Selection in Euplotes
AbstractIn most of the studied organisms, gene expression is associated with a number of evolutionary features pertaining to the protein-coding...
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A comparison of marker gene selection methods for single-cell RNA sequencing data
BackgroundThe development of single-cell RNA sequencing (scRNA-seq) has enabled scientists to catalog and probe the transcriptional heterogeneity of...
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Gene Selection in a Single Cell Gene Space Based on D–S Evidence Theory
If the samples, features and information values in a real-valued information system are cells, genes and gene expression values, respectively, then...
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ZINBMM: a general mixture model for simultaneous clustering and gene selection using single-cell transcriptomic data
Clustering is a critical component of single-cell RNA sequencing (scRNA-seq) data analysis and can help reveal cell types and infer cell lineages....
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Prediction of lung cancer using gene expression and deep learning with KL divergence gene selection
BackgroundLung cancer is one of the cancers with the highest mortality rate in China. With the rapid development of high-throughput sequencing...
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Dual specificity and target gene selection by the MADS-domain protein FRUITFULL
How transcription factors attain their target gene specificity and how this specificity may be modulated, acquiring different regulatory functions...
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Purifying selection leads to low protein diversity of the mitochondrial cyt b gene in avian malaria parasites
BackgroundMitochondrial respiration plays a central role in the survival of many eukaryotes, including apicomplexan parasites. A 479-bp fragment from...
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Recent gene selection and drug resistance underscore clinical adaptation across Candida species
Understanding how microbial pathogens adapt to treatments, humans and clinical environments is key to infer mechanisms of virulence, transmission and...
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In Vitro Amplification and Selection of Engineered RNase P Ribozyme for Gene Targeting Applications
Ribozymes engineered from the RNase P catalytic RNA (M1 RNA) represent promising gene-targeting agents for clinical applications. We describe in this...
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Efficient gene editing through an intronic selection marker in cells
BackgroundGene editing technology has provided researchers with the ability to modify genome sequences in almost all eukaryotes. Gene-edited cell...
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Robust markers associated with floral traits in roses are suitable for marker-assisted selection across gene pools
We investigated the potential of markers associated with floral traits for parental selection in a cut rose breeding program. We analysed six...
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Gene editing with an oxathiapiprolin resistance selection marker reveals that PuLLP, a loricrin-like protein, is required for oospore development in Pythium ultimum
Oomycetes, such as Pythium species, contain numerous devastating plant pathogens that inflict substantial economic losses worldwide. Although...
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Analysis of polygenic selection in purebred and crossbred pig genomes using generation proxy selection map**
BackgroundArtificial selection on quantitative traits using breeding values and selection indices in commercial livestock breeding populations causes...
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Genetic diversity and selection signatures in a gene bank panel of maize inbred lines from Southeast Europe compared with two West European panels
Southeast Europe (SEE) is a very important maize-growing region, comparable to the Corn belt region of the United States, with similar dent germplasm...
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Improving blast resistance of maintainer line DRR 9B by transferring broad spectrum resistance gene Pi2 by marker assisted selection in rice
Hybrid rice technology offers great promise to further enhance rice production and productivity for global food security. Improving hybrid rice...
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A dual-function selection system enables positive selection of multigene CRISPR mutants and negative selection of Cas9-free progeny in Arabidopsis
The CRISPR/Cas9 technology revolutionizes targeted gene knockout in diverse organisms including plants. However, screening edited alleles,...
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Neofunctionalization driven by positive selection led to the retention of the loqs2 gene encoding an Aedes specific dsRNA binding protein
BackgroundMosquito borne viruses, such as dengue, Zika, yellow fever and Chikungunya, cause millions of infections every year. These viruses are...
