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1. Neuroprotective effects of the PPARβ/δ antagonist GSK0660 in in vitro and in vivo Parkinson’s disease models

   Background

   The underlying mechanism of Parkinson’s disease are still unidentified, but excitotoxicity, oxidative stress, and neuroinflammation are...

   Andrea Antonosante, Vanessa Castelli, ... Michele d’Angelo in Biological Research

   Article Open access 25 May 2023
   

2. PPARβ/δ priming enhances the anti-apoptotic and therapeutic properties of mesenchymal stromal cells in myocardial ischemia–reperfusion injury

   Background

   Mesenchymal Stromal Cells (MSC) have been widely used for their therapeutic properties in many clinical applications including myocardial...

   Charlotte Sarre, Rafael Contreras-Lopez, ... Stéphanie Barrere-Lemaire in Stem Cell Research & Therapy

   Article Open access 23 April 2022
   

3. PPARβ/δ accelerates bone regeneration in diabetic mellitus by enhancing AMPK/mTOR pathway-mediated autophagy

   Background

   Diabetic patients are more vulnerable to skeletal complications. Peroxisome proliferators-activated receptor (PPAR) β/δ has a positive...

   Miao Chen, Dian **g, ... Zhihe Zhao in Stem Cell Research & Therapy

   Article Open access 04 November 2021
   

4. Selective deletion of PPARβ/δ in fibroblasts causes dermal fibrosis by attenuated LRG1 expression

   Connective tissue diseases of the skin are characterized by excessive collagen deposition in the skin and internal organs. Fibroblasts play a pivotal...

   Ming Keat Sng, Jeremy Soon Kiat Chan, ... Nguan Soon Tan in Cell Discovery

   Article Open access 03 April 2018
   

5. Protective Effect of Unsaturated Fatty Acids on Palmitic Acid-Induced Toxicity in Skeletal Muscle Cells is not Mediated by PPARδ Activation

   Unsaturated free fatty acids (FFA) are able to prevent deleterious effects of saturated FFA in skeletal muscle cells although the mechanisms involved...

   Jana Tumova, Lucia Malisova, ... Jan Trnka in Lipids

   Article 09 August 2015
   

6. Peroxisome proliferator-activated receptorβ/δ activation is essential for modulating p-Foxo1/Foxo1 status in functional insulin-positive cell differentiation

   Peroxisome proliferator-activated receptors (PPARs) participate in energy homeostasis and play essential roles in diabetes therapy through their...

   L Li, T Li, ... Y Lou in Cell Death & Disease

   Article Open access 09 April 2015
   

7. The PPARβ/δ agonist GW0742 modulates signaling pathways associated with cardiac myocyte growth via a non-genomic redox mechanism

   Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor...

   Eleftheria Galatou, Tara Kelly, Antigone Lazou in Molecular and Cellular Biochemistry

   Article 18 June 2014
   

8. PPARδ regulates satellite cell proliferation and skeletal muscle regeneration

   Peroxisome proliferator-activated receptors (PPARs) are a class of nuclear receptors that play important roles in development and energy metabolism....

   Alison R Angione, Chunhui Jiang, ... Shihuan Kuang in Skeletal Muscle

   Article Open access 01 November 2011