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Turning the spotlight on the oligosaccharide chain of GM1 ganglioside
It is well over a century that glycosphingolipids are matter of interest in different fields of research. The hydrophilic oligosaccharide and the...
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Modulation of calcium signaling depends on the oligosaccharide of GM1 in Neuro2a mouse neuroblastoma cells
Recently, we demonstrated that the oligosaccharide portion of ganglioside GM1 is responsible, via direct interaction and activation of the TrkA...
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GM1 structural requirements to mediate neuronal functions
Since the 1980s, it has been known that the administration of ganglioside GM1 to cultured cells induced or enhanced neuronal differentiation. GM1...
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The oligosaccharide portion of ganglioside GM1 regulates mitochondrial function in neuroblastoma cells
The crucial role of ganglioside GM1 in the regulation of neural homeostasis has been assessed by several studies. Recently we shed new light on the...
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Gangliosides in the differentiation process of primary neurons: the specific role of GM1-oligosaccharide
It has been recently reported by our group that GM1-oligosaccharide added to neuroblastoma cells or administered to mouse experimental model mimics...
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Plasma membrane glycosphingolipid signaling: a turning point
Plasma membrane interaction is highly recognized as an essential step to start the intracellular events in response to extracellular stimuli. The...
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Chemical Synthesis of Gangliosides
Synthetic methodologies for gangliosides have evolved over the past three decades. The strategies for constructing ganglioside skeletons can...
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Assays and Utilization of Enzymes Involved in Glycolipid Metabolism in Bacteria and Fungi
Microbial glycosphingolipid (GSL)-degrading enzymes with unique specificity are useful tools for GSL research. On the other hand, some microbial...
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Novel insights on GM1 and Parkinson's disease: A critical review
GM1 is a crucial component of neuronal membrane residing both in the soma and nerve terminals. As reported in Parkinson’s disease patients, the...
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Experimental and computational characterization of dynamic biomolecular interaction systems involving glycolipid glycans
On cell surfaces, carbohydrate chains that modify proteins and lipids mediate various biological functions, which are exerted not only through...
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Characterization of Gangliosides from Mouse Optic Nerve Samples Using Mass Spectrometry
This chapter focuses on identifying gangliosides in the optic nerve of the mouse using mass spectrometry techniques. The described protocol will also...
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Dendrimeric Entities as Chemical Alternatives Toward Antimicrobial Therapy
The intrinsic ability of certain pathogenic microbes to grow resistance toward the beneficial impressions of various antimicrobial medications...
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A paintbrush for delivery of nanoparticles and molecules to live cells with precise spatiotemporal control
Delivery of very small amounts of reagents to the near-field of cells with micrometer spatial precision and millisecond time resolution is currently...
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Role of SIRT1 in Potentially Toxic Trace Elements (Lead, Fluoride, Aluminum and Cadmium) Associated Neurodevelopmental Toxicity
The formation of the central nervous system is a meticulously planned and intricate process. Any modification to this process has the potential to...
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Advancements in understanding bacterial enteritis pathogenesis through organoids
Bacterial enteritis has a substantial role in contributing to a large portion of the global disease burden and serves as a major cause of newborn...
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Alkali-labile gangliosides
The structure and properties of a group of gangliosides modified by mild alkaline treatment are discussed. We will present the occurrence and the...
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Glycosphingolipids
Glycosphingolipids are amphiphilic plasma membrane components formed by a glycan linked to a specific lipid moiety. In this chapter we report on...
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Innovative treatment targeting gangliosides aimed at blocking the formation of neurotoxic α-synuclein oligomers in Parkinson’s disease
Parkinson’s disease (PD) is a major neurodegenerative disorder which exhibits many of the characteristics of a pandemic. Current therapeutic...
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GM2/GM3 controls the organizational status of CD82/Met microdomains: further studies in GM2/GM3 complexation
At cell surface gangliosides might associate with signal transducers proteins, grown factor receptors, integrins, small G-proteins and tetraspanins...
