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“Glyco-sulfo barcodes” regulate chemokine receptor function
Chemokine ligands and receptors regulate the directional migration of leukocytes. Post-translational modifications of chemokine receptors including...
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Analysis of the glyco-code in pancreatic ductal adenocarcinoma identifies glycan-mediated immune regulatory circuits
Pancreatic ductal adenocarcinoma (PDAC) remains one of the most aggressive malignancies with a 5-year survival rate of only 9%. Despite the fact that...
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Functional glyco-metagenomics elucidates the role of glycan-related genes in environments
BackgroundGlycan-related genes play a fundamental role in various processes for energy acquisition and homeostasis maintenance while adapting to the...
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Fast and comprehensive N- and O-glycoproteomics analysis with MSFragger-Glyco
Recent advances in methods for enrichment and mass spectrometric analysis of intact glycopeptides have produced large-scale glycoproteomics datasets,...
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40 years of glyco-polyacrylamide in glycobiology
Polyacrylamide conjugates of glycans have long been widely used in many research areas of glycobiology, mainly for immobilizing glycans in...
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ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3Gal1) synthesis of Siglec ligands mediates anti-tumour immunity in prostate cancer
Immune checkpoint blockade has yet to produce robust anti-cancer responses for prostate cancer. Sialyltransferases have been shown across several...
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Glyco-DIA: a method for quantitative O-glycoproteomics with in silico-boosted glycopeptide libraries
We report a liquid chromatography coupled to tandem mass spectrometry O -glycoproteomics strategy using data-independent acquisition (DIA) mode for...
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Inhibitory potency of the nettle lectin on neovascularization: a biomolecule for carbohydrate-mediated targeting of angiogenesis
BackgroundCurrent angiogenesis inhibitors target cellular vascularization processes, including proliferation, migration, and tube formation. In this...
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Integrating transcriptomics, glycomics and glycoproteomics to characterize hepatitis B virus-associated hepatocellular carcinoma
BackgroundHepatocellular carcinoma (HCC) ranks as the third most common cause of cancer related death globally, representing a substantial challenge...
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Production of N-glycosylated alcohol dehydrogenase in Escherichia coli
N-glycosylation of recombinant proteins using bacterial glycosylation system has proven to be a valuable although develo** tool ultimately...
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Informatics Ecosystems to Advance the Biology of Glycans
Glycomics researchers have identified the need for integrated database systems for collecting glycomics information in a consistent format. The goal...
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Statistical and Artificial Neural Network Approaches to Modeling and Optimization of Fermentation Conditions for Production of a Surface/Bioactive Glyco-lipo-peptide
A freshwater alkaliphilic strain of Pseudomonas aeruginosa, grown on waste frying oil-basal medium, produced a surface-active metabolite identified...
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Tools & Techniques of Plant Molecular Farming
This edited book is an in-depth compilation of recent tools and techniques, concepts and strategies used globally in plant molecular farming (PMF)...
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Soil and Plant Cover and Microbial–Biomorphic Assessment of Ecosystems in Coastal Depressions of Highly Mineralized Drainless Pulsating Lakes of Dauria (Southeastern Transbaikalia)
AbstractThe soils, vegetation cover, and microbiota of coastal depressions of highly mineralized drainless chloride lakes in southeastern...
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Endoglycosidase assay using enzymatically synthesized fluorophore-labeled glycans as substrates to uncover enzyme substrate specificities
Glycan synthesis and degradation are not template but enzyme only driven processes. Substrate specificities of glyco-enzymes determine the structures...
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Transcriptionally imprinted glycomic signatures of acute myeloid leukemia
BackgroundAcute myeloid leukemia (AML) is a genetically and phenotypically heterogeneous disease that has been suffering from stagnant survival...
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Characterization of substrate specificity and inhibitory mechanism of bile salt hydrolase from Lactobacillus reuteri CRL 1098 using molecular docking analysis
ObjectivesTo elucidate the molecular mechanisms involved in the substrate interaction of the bile salt hydrolase of Lactobacillus reuteri CRL 1098...
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Carbohydrate Structure Database and Other Glycan Databases as an Important Element of Glycoinformatics
Abstract—Carbohydrates are one of the most chemically diverse classes of biomolecules. The amount of accumulated information on carbohydrates is far...
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Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the development and homeostasis...
