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Unveiling the crucial role of betaine: modulation of GABA homeostasis via SLC6A1 transporter (GAT1)
Betaine is an endogenous osmolyte that exhibits therapeutic potential by mitigating various neurological disorders. However, the underlying cellular...
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Molecular basis for substrate recognition and transport of human GABA transporter GAT1
γ-Aminobutyric acid (GABA), an important inhibitory neurotransmitter in the central nervous system, is recycled through specific GABA transporters...
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Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism
The inhibitory neurotransmitter γ-aminobutyric acid (GABA) is cleared from the synaptic cleft by the sodium- and chloride-coupled GABA transporter...
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Changes in the Glutamate/GABA System in the Hippocampus of Rats with Age and during Alzheimer’s Disease Signs Development
AbstractGABA and glutamate are the most abundant neurotransmitters in the CNS and play a pivotal part in synaptic stability/plasticity. Glutamate and...
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Inhibition of GABA-Transaminase and GABA-Transporters in the Brain by Vigabatrin and Tiagabine Prevents Seizure Development in Rats Breathing Hyperbaric Oxygen
AbstractHyperbaric oxygen (HBO 2 ) inhibits the GABAergic function in the brain, leading to the development of convulsive reactions in the form of...
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Protein–Protein Interactions in Neurodegenerative Diseases
Neurodegeneration is a state of progressive decay of neuronal structure and function. It has gained scientific attention owing to the fact that...
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Inhibitors of DNA Methylation
DNA methylation is involved in numerous biological processes and is deregulated in human diseases. The modulation of the activity of the enzymes and...
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Role of sodium dependent SLC13 transporter inhibitors in various metabolic disorders
The sodium dependent SLC13 family transporters comprise of five genes SLC13A1, SLC13A2 (NaDC1), SLC13A3 (NaDC3), SLC13A4 and SLC13A5 (NaCT). Among...
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Protein-Protein Interactions in Host–Pathogen Interactions
Human body is vulnerable to infection by several causative agents like viruses, bacteria, fungi, and protozoa. Currently, a lot of importance has...
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HL-7 and HL-10 Peptides Stimulate Insulin Secretion in the INS-1 Insulinoma Cell Line through Incretin-Dependent Pathway and Increasing the Glucose Uptake in L6 Myoblast
In this study, the effect of two peptides, namely HL-7 and HL-10, on the percentage of cell death in L6 myoblast, proliferation, and metabolism of...
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Role of the AMP-Activated Protein Kinase in the Pathogenesis of Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) is a complex disorder characterized by elevated androgen levels, menstrual irregularities, and polycystic morphology...
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Structures of synaptic vesicle protein 2A and 2B bound to anticonvulsants
Epilepsy is a common neurological disorder characterized by abnormal activity of neuronal networks, leading to seizures. The racetam class of...
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Analysis of the Functional State of Astroglia in the Hippocampus of Rats Genetically Prone to Audiogenic Seizures
AbstractIt was shown that abnormalities in astrocyte functions can cause alterations in neuronal excitability and promote the development of...
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Rational approaches for the design of various GABA modulators and their clinical progression
AbstractGABA (γ-amino butyric acid) is an important inhibitory neurotransmitter in the central nervous system. Attenuation of GABAergic...
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Cerebral venous congestion alters CNS homeostatic plasticity, evoking tinnitus-like behavior
BackgroundBrain function and neuronal activity depend on a constant supply of blood from the cerebral circulation. The cerebral venous system (CVS)...
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2,3,5-triiodobenzoic acid affects the in vitro propagation of Cedrela fissilis Vell. (Meliaceae) through alterations in endogenous polyamine and indol-3-acetic acid levels and the proteomic profile
Endogenous levels of some molecules, such as polyamines (PAs) and auxin, can be associated with the control of shoot and root development. The...
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Oxysterols in Central and Peripheral Synaptic Communication
Cholesterol is a key molecule for synaptic transmission, and both central and peripheral synapses are cholesterol rich. During intense neuronal...
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Homology Modeling of Transporter Proteins
Membrane transporter proteins are divided into channels/pores and carriers and constitute protein families of physiological and pharmacological...
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Cannabis and Parkinson’s Disease
Parkinson’s disease is a slowly progressive, degenerative disorder characterized by resting tremors, stiffness (rigidity), slow and decreased...