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Prioritization and functional validation of target genes from single-cell transcriptomics studies
Translation of academic results into clinical practice is a formidable unmet medical need. Single-cell RNA-sequencing (scRNA-seq) studies generate...
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An Integrated Bioinformatics and Functional Approach for miRNA Validation
MicroRNAs (miRNAs) are small (20–24 nucleotides) non-coding ribo-regulatory molecules with significant roles in regulating target mRNA and long...
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Plant Functional Genomics Methods and Protocols, Volume 2
This detailed book gathers hands-on techniques to characterize, identify, localize, profile, and determine genome functions in plants. Volume 2 opens...
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Identification and functional validation of HLA-C as a potential gene involved in colorectal cancer in the Korean population
BackgroundColorectal cancer (CRC) is the third most common cancer worldwide and is influenced by environmental and genetic factors. Although numerous...
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Functional Genomics and Network Biology
Functional genomics and network biology have emerged as interdisciplinary fields that provide a comprehensive understanding of biological systems....
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Functional and structural reorganization in brain tumors: a machine learning approach using desynchronized functional oscillations
Neuroimaging studies have allowed for non-invasive map** of brain networks in brain tumors. Although tumor core and edema are easily identifiable...
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CRISPR single base editing, neuronal disease modelling and functional genomics for genetic variant analysis: pipeline validation using Kleefstra syndrome EHMT1 haploinsufficiency
BackgroundOver 400 million people worldwide are living with a rare disease. Next Generation Sequencing (NGS) identifies potential disease causative...
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Screening and Characterization of Functional circRNAs in Neuronal Cultures
This chapter describes a methodology for the screening and characterization of functional circRNAs, particularly in the context of neural circuit...
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Functional Genomics of Novel Rhabdomyosarcoma Fusion-Oncogenes Using Zebrafish
Clinical sequencing efforts continue to identify novel putative oncogenes with limited strategies to perform functional validation in vivo and study...
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Genome-wide identification of the C2H2-Zinc finger gene family and functional validation of CsZFP7 in citrus nucellar embryogenesis
Key MessageGenome-wide identification of C2H2-ZF gene family in the poly- and mono-embryonic citrus species and validation of the positive role of CsZFP7...
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Precision genetic technologies for cereal functional genomics
Identifying and characterizing genes that control important agronomic traits and finding ways to alter them are vital for crop improvement. Map-based...
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Identification and validation of key biomarkers and potential therapeutic targets for primary open-angle glaucoma
Primary open-angle glaucoma (POAG) is a prevalent cause of blindness worldwide, resulting in degeneration of retinal ganglion cells and permanent...
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Identification and validation of microbial biomarkers from cross-cohort datasets using xMarkerFinder
Microbial signatures have emerged as promising biomarkers for disease diagnostics and prognostics, yet their variability across different studies...
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Identification and validation of biomarkers related to lipid metabolism in osteoarthritis based on machine learning algorithms
BackgroundOsteoarthritis and lipid metabolism are strongly associated, although the precise targets and regulatory mechanisms are unknown.
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Optimized protoplast isolation and transfection with a breakpoint: accelerating Cas9/sgRNA cleavage efficiency validation in monocot and dicot
The CRISPR-Cas genome editing tools are revolutionizing agriculture and basic biology with their simplicity and precision ability to modify target...
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Intragenic Duplications in Diatoms: Search and Validation
AbstractIt has previously been demonstrated that some diatom genes contain a single reading frame encoding several concatenated copies of a protein...
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Transcriptome analysis and functional validation reveal the novel role of LhCYCL in axillary bud development in hybrid Liriodendron
Shoot branching significantly influences yield and timber quality in woody plants, with hybrid Liriodendron being particularly valuable due to its...
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Microalgae amino acids: Method validation using gas chromatography coupled to mass spectrometry
This study aimed to develop a method for determining protein amino acids in microalgae using gas chromatography coupled with mass spectrometry. To...
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Serum metabolic signatures for Alzheimer’s Disease reveal alterations in amino acid composition: a validation study
IntroductionAlzheimer’s Disease (AD) is complex and novel approaches are urgently needed to aid in diagnosis. Blood is frequently used as a source...
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Functional Regression
This chapter deals with the main theoretical fundamentals and practical issues of using functional regression in the context of genomic prediction....