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Characterization of free fatty acid receptor family in rainbow trout (Oncorhynchus mykiss): towards a better understanding of their involvement in fatty acid signalisation
Since 20 years of research, free fatty acids receptors (FFARs) have received considerable attention in mammals. To date, four FFARs (FFAR1, FFAR2,...
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Sterols, free fatty acids, and total fatty acid content in the massive Porites spp. corals cultured under different pCO2 and temperature treatments
Lipids may serve as energy reserves to support coral calcification, allow acclimation to higher temperatures, and are implicated in the control of...
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Engineering Pseudomonas putida KT2440 for chain length tailored free fatty acid and oleochemical production
Despite advances in understanding the metabolism of Pseudomonas putida KT2440, a promising bacterial host for producing valuable chemicals from...
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In Vivo Imaging of Bone Marrow Long-Chain Fatty Acid Uptake
In vivo imaging enables the detection and visualization of many different processes occurring within the body. Fatty acid uptake is a fundamental...
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GLUT4 localisation with the plasma membrane is unaffected by an increase in plasma free fatty acid availability
BackgroundInsulin-stimulated glucose uptake into skeletal muscle occurs via translocation of GLUT4 from intracellular storage vesicles to the plasma...
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Inhibition of fatty acid uptake by TGR5 prevents diabetic cardiomyopathy
Diabetic cardiomyopathy is characterized by myocardial lipid accumulation and cardiac dysfunction. Bile acid metabolism is known to play a crucial...
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Fatty Acid Profiling of Grapevine Extracellular Compartment
The apoplast is the plant compartment present between the plasma membrane and the cuticle, comprised of the cell wall and the extracellular spaces...
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Fatty acid metabolism of immune cells: a new target of tumour immunotherapy
Metabolic competition between tumour cells and immune cells for limited nutrients is an important feature of the tumour microenvironment (TME) and is...
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Fatty Acid Synthase: Structure, Function, and Regulation
Fatty acid (FA) biosynthesis plays a central role in the metabolism of living cells as building blocks of biological membranes, energy reserves of...
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The role of fatty acid metabolism in acute lung injury: a special focus on immunometabolism
Reputable evidence from multiple studies suggests that excessive and uncontrolled inflammation plays an indispensable role in mediating, amplifying,...
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Proteolytic activation of fatty acid synthase signals pan-stress resolution
Chronic stress and inflammation are both outcomes and major drivers of many human diseases. Sustained responsiveness despite mitigation suggests a...
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PCYT1A deficiency disturbs fatty acid metabolism and induces ferroptosis in the mouse retina
BackgroundInherited retinal dystrophies (IRDs) are a group of debilitating visual disorders characterized by the progressive degeneration of...
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Gluten worsens non-alcoholic fatty liver disease by affecting lipogenesis and fatty acid oxidation in diet-induced obese apolipoprotein E-deficient mice
Obesity is closely associated with non-alcoholic fatty liver disease (NAFLD), characterized by hepatic fat accumulation and hepatocyte injury....
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Growth and fatty acid profile of Nannochloropsis oceanica cultivated on nano-filtered whey permeate
Nano-filtered whey permeate (WP), a major by-product of dairy industry, is produced by membrane filtration of whey. The oleaginous microalga Nannochlor...
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Non-alcoholic fatty liver disease promotes liver metastasis of colorectal cancer via fatty acid synthase dependent EGFR palmitoylation
Liver metastasis is the major reason for most of colorectal cancer (CRC) related deaths. Accumulating evidence indicates that CRC patients with...
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Arf1 coordinates fatty acid metabolism and mitochondrial homeostasis
Lipid mobilization through fatty acid β-oxidation is a central process essential for energy production during nutrient shortage. In yeast, this...
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Fatty acid oxidation organizes mitochondrial supercomplexes to sustain astrocytic ROS and cognition
Having direct access to brain vasculature, astrocytes can take up available blood nutrients and metabolize them to fulfil their own energy needs and...
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Ionizing radiation-induced mitophagy promotes ferroptosis by increasing intracellular free fatty acids
Ferroptosis is a type of cell death characterized by the accumulation of intracellular iron and an increase in hazardous lipid peroxides. Ferroptosis...
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Transcriptome analyses of Acer Truncatum Bunge seeds to delineate the genes involved in fatty acid metabolism
BackgroundAcer truncatum Bunge is an economic, ecological, oil, and medicinal tree, and its kernel oil is rich in nervonic acid. It is crucial to...
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Bioproduction of n-3 polyunsaturated fatty acids by nematode fatty acid desaturases and elongase in Drosophila melanogaster
n-3 polyunsaturated fatty acids (n-3 PUFAs), including α-linolenic acid and eicosapentaenoic acid (EPA), are essential nutrients for vertebrates...
