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Fragment-Based Drug Design in Lead Discovery
This chapter focuses on the main new drug development strategies using the fragment-based drug design (FBDD) approach and its relationship with...
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Analysis of the droplet size and distribution for micro-sprinkling hose based on the LPM
A micro-sprinkling hose is promising water-saving irrigation equipment due to its low cost and ease of installation and dismantlement during...
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Modeling fragment counts improves single-cell ATAC-seq analysis
Single-cell ATAC sequencing coverage in regulatory regions is typically binarized as an indicator of open chromatin. Here we show that binarization...
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Specific-Locus Amplified Fragment Sequencing (SLAF-Seq)
Specific length amplified fragment sequencing (SLAF-seq) technology is a simplified genome sequencing technology based on next-generation sequencing....
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Lowland forest fragment characteristics and anthropogenic disturbances determine alien plant species richness and composition
Loss of habitat and biological invasion are the main threats to biodiversity. In intensive agricultural or urban landscapes, forest fragments, even...
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Classification of likely functional class for ligand binding sites identified from fragment screening
Fragment screening is used to identify binding sites and leads in drug discovery, but it is often unclear which binding sites are functionally...
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HIPPO: HIstogram-based Pseudo-POtential for scoring protein-ssRNA fragment-based docking poses
BackgroundThe RNA-Recognition motif (RRM) is a protein domain that binds single-stranded RNA (ssRNA) and is present in as much as 2% of the human...
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Enhancing drug property prediction with dual-channel transfer learning based on molecular fragment
BackgroundAccurate prediction of molecular property holds significance in contemporary drug discovery and medical research. Recent advances in...
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Identification and functional analysis of a chromosome 2D fragment harboring TaFPF1 gene with the potential for yield improvement using a late heading wheat mutant
Key messageA chromosome fragment influencing wheat heading and grain size was identified using map** of m406 mutant. The study of TaFPF1 in this...
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Map** crossover events of mouse meiotic recombination by restriction fragment ligation-based Refresh-seq
Single-cell whole-genome sequencing methods have undergone great improvements over the past decade. However, allele dropout, which means the...
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A designer synthetic chromosome fragment functions in moss
Rapid advances in DNA synthesis techniques have enabled the assembly and engineering of viral and microbial genomes, presenting new opportunities for...
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Towards systematic exploration of chemical space: building the fragment library module in molecular property diagnostic suite
A fragment-based drug discovery (FBDD) approach has traditionally been of utmost significance in drug design studies. It allows the exploration of...
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Dietary and habitat specialization, eye size, clutch size, and aerial lifestyle predict avian fragmentation sensitivity in an Andean biodiversity hotpot
The fragmentation of tropical forests remains a major driver of avian biodiversity loss, particularly for insectivores, yet the mechanisms underlying...
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The η-secretase-derived APP fragment ηCTF is localized in Golgi, endosomes and extracellular vesicles and contributes to Aβ production
The processing of the amyloid precursor protein (APP) is one of the key events contributing to Alzheimer’s disease (AD) etiology. Canonical cleavages...
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The C-terminal 32-mer fragment of hemoglobin alpha is an amyloidogenic peptide with antimicrobial properties
Antimicrobial peptides (AMPs) are major components of the innate immune defense. Accumulating evidence suggests that the antibacterial activity of...
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Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment
Claudins are a 27-member family of ~25 kDa membrane proteins that integrate into tight junctions to form molecular barriers at the paracellular...
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Functionally divergent growth, biomass allocation and root distribution of two xerophytic species in response to varying soil rock fragment content
AimsRock fragments are widespread in soil profiles. Despite direct effects of rock fragment content (RFC) on vegetation and soil properties, how...
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In planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation
In humans, aggregation of polyglutamine repeat (polyQ) proteins causes disorders such as Huntington’s disease. Although plants express hundreds of...
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The BACE1-generated C-terminal fragment of the neural cell adhesion molecule 2 (NCAM2) promotes BACE1 targeting to Rab11-positive endosomes
Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), also known as β-secretase, is an aspartic protease. The sorting of this enzyme into...
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The influence of size and distance of Atlantic forest patches on seed rain over tropical pasture
Atlantic Forest has experienced an expansion of vegetation fragments in abandoned pasture areas. Thus, we aimed to evaluate seed rain over abandoned...
