Search
Search Results
-
FOXO family isoforms
FOXO family of proteins are transcription factors involved in many physiological and pathological processes including cellular homeostasis, stem cell...
-
FOXO transcription factors as mediators of stress adaptation
The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6) transcription factors are the mammalian orthologues of Caenorhabditis...
-
Targeting cis-regulatory elements of FOXO family is a novel therapeutic strategy for induction of leukemia cell differentiation
Differentiation therapy has been proposed as a promising therapeutic strategy for acute myeloid leukemia (AML); thus, the development of more...
-
Dorsomorphin inhibits AMPK, upregulates Wnt and Foxo genes and promotes the activation of dormant follicles
AMPK is a well-known energy sensor regulating cellular metabolism. Metabolic disorders such as obesity and diabetes are considered detrimental...
-
Tctp regulates the level and localization of Foxo for cell growth in Drosophila
Regulation of cell size is crucial for organ development. Insulin signaling regulates organ size by antagonizing the subgroup O of forkhead box...
-
Exosomal YB-1 facilitates ovarian restoration by MALAT1/miR-211-5p/FOXO3 axis
Premature ovarian failure (POF) affects many adult women less than 40 years of age and leads to infertility. Mesenchymal stem cells-derived small...
-
Role of FoxO transcription factors in aging and age-related metabolic and neurodegenerative diseases
Aging happens to all of us as we live. Thanks to the improved living standard and discovery of life-saving medicines, our life expectancy has...
-
Down-regulated FTO and ALKBH5 co-operatively activates FOXO signaling through m6A methylation modification in HK2 mRNA mediated by IGF2BP2 to enhance glycolysis in colorectal cancer
BackgroundN6-methyladenosine (m6A) modification is the most abundant reversible methylation modification in eukaryotes, and it is reportedly closely...
-
miRNA-559 and MTDH as possible diagnostic markers of psoriasis: Role of PTEN/AKT/FOXO pathway in disease pathogenesis
Psoriasis is a persistent, inflammatory, autoimmune skin disorder which can be elicited by genetic and environmental factors. Several microRNAs...
-
FoxO maintains a genuine muscle stem-cell quiescent state until geriatric age
Tissue regeneration declines with ageing but little is known about whether this arises from changes in stem-cell heterogeneity. Here, in homeostatic...
-
In vitro study of the role of FOXO transcription factors in regulating cigarette smoke extract-induced autophagy
Cigarette smoking is the chief etiological factor for chronic obstructive pulmonary disease (COPD). Oxidative stress induced by cigarette smoke (CS)...
-
Forkhead box O proteins: steering the course of stem cell fate
Stem cells are pivotal players in the intricate dance of embryonic development, tissue maintenance, and regeneration. Their behavior is delicately...
-
Control of endothelial quiescence by FOXO-regulated metabolites
Endothelial cells (ECs) adapt their metabolism to enable the growth of new blood vessels, but little is known how ECs regulate metabolism to adopt a...
-
FoxO directly regulates the expression of TOR/S6K and vitellogenin to modulate the fecundity of the brown planthopper
As a conserved transcription factor, FoxO plays a crucial role in multiple physiological processes in vivo , including stress resistance, longevity,...
-
Store-Operated Calcium Channel and Inositol Triphosphate Receptor Calcium Channel Hyperactivation Inhibits Hepatocyte Autophagy to Promote Nonalcoholic Fatty Liver Disease
AbstractPreviously, we demonstrated that store-operated calcium channel (SOCC) and inositol triphosphate receptor (IP3R) calcium channel upregulation...
-
Tectochrysin increases stress resistance and extends the lifespan of Caenorhabditis elegans via FOXO/DAF-16
Aging is related to the lowered overall functioning and increased risk for various age-related diseases in humans. Tectochrysin is a flavonoid...
-
CSNK1D-mediated phosphorylation of HNRNPA2B1 induces miR-25-3p/miR-93-5p maturation to promote prostate cancer cell proliferation and migration through m6A-dependent manner
It has been reported that heterogeneous nuclear ribonucleoprotein A2/B1 (HNRNPA2B1) is highly expressed in prostate cancer (PCa) and associated with...
-
Mechanistic insights into the alterations and regulation of the AKT signaling pathway in diabetic retinopathy
In the early stages of diabetic retinopathy (DR), diabetes-related hyperglycemia directly inhibits the AKT signaling pathway by increasing oxidative...
-
Evaluation of silent information regulator T (SIRT) 1 and Forkhead Box O (FOXO) transcription factor 1 and 3a genes in glaucoma
Analysis of the reactive oxygen species (ROS)-detoxifying biomarkers may elucidate the mitochondrial dysfunction in glaucoma pathogenesis. Therefore,...