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Metabolic signatures in human follicular fluid identify lysophosphatidylcholine as a predictor of follicular development
In order to investigate the metabolic characteristics of human follicular fluid (FF) and to reveal potential metabolic predictors of follicular...
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Follicular fluid C3a-peptide promotes oocyte maturation through F-actin aggregation
BackgroundImmature cumulus-oocyte complexes are retrieved to obtain mature oocytes by in vitro maturation (IVM), a laboratory tool in reproductive...
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Transcriptomics and metabolomics of blood, urine and ovarian follicular fluid of yak at induced estrus stage
To gain a deeper understanding of the metabolic differences within and outside the body, as well as changes in transcription levels following estrus...
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Characterization of bovine uterine fluid extracellular vesicles proteomic profiles at follicular and luteal phases of the oestrous cycle
Extracellular vesicles (EV) have been identified in uterine fluid (UF), however the bovine UF-EV profile during different phases of the oestrous...
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The Influence of Follicular Fluid Metals on Assisted Reproduction Outcome
Infertility has become more common, with an increased exposure to toxic compounds including heavy metals (HM). Follicular fluid (FF) surrounds the...
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Decreased histidine-rich glycoprotein and increased complement C4-B protein levels in follicular fluid predict the IVF outcomes of recurrent spontaneous abortion
BackgroundRecurrent spontaneous abortion (RSA) is a common and complicated pregnancy-related disease that lacks a suitable biomarker to predict its...
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Follicular fluid-derived exosomal miR-143-3p/miR-155-5p regulate follicular dysplasia by modulating glycolysis in granulosa cells in polycystic ovary syndrome
ObjectivePolycystic ovary syndrome (PCOS) is characterized by follicular dysplasia. An insufficient glycolysis-derived energy supply of granulosa...
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Does the addition of follicular fluid in the in vitro maturation medium increase the oocyte maturation and embryo production in alpacas?
In alpacas ( Vicugna pacos ), the high cost of in vitro embryo production is also a consequence of the use of several substances in the culture medium....
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Global proteomic analysis of the follicular fluid from brown brocket deer (Mazama gouazoubira; Fisher, 1814)
Understanding the protein composition of the follicular fluid from brown brocket deer would aid the development of a medium for in vitro embryo...
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Lipid metabolites, interleukin-6 and oxidative stress markers in follicular fluid and their association with serum concentrations in mares
The application of trans-vaginal ovum pick up (OPU) and intracytoplasmic sperm injection (ICSI) is well established for commercial in vitro embryo...
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High levels of follicular fluid testosterone could impair oocyte developmental competency via affecting aryl hydrocarbon receptor pathway in PCOS patients
BackgroundAlthough hormonal and metabolic dysfunction have been recognized as a possible cause of polycystic ovarian syndrome (PCOS), the...
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Association Between Exposure to Multiple Toxic Metals in Follicular Fluid and the Risk of PCOS Among Infertile Women: The Mediating Effect of Metabolic Markers
Polycystic ovary syndrome (PCOS) severely affects women's fertility and accompanies serious metabolic disturbances, affecting 5%-20% of women of...
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Iron-overloaded follicular fluid increases the risk of endometriosis-related infertility by triggering granulosa cell ferroptosis and oocyte dysmaturity
Endometriosis (EMs) occurs in approximately 50% of women with infertility. The main causes of EMs-related infertility are follicle dysplasia and...
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Multi-omics analysis reveals gut microbiota-ovary axis contributed to the follicular development difference between Meishan and Landrace × Yorkshire sows
BackgroundThe mechanism by which Meishan (MS) sows are superior to white crossbred sows in ovarian follicle development remains unclear. Given gut...
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ZnT 9 Involvement in Estradiol-Modulated Zinc Homeostasis of the Human Follicular Microenvironment
Female subfertility has been a growing concern for reproductive health. Assisted reproductive technologies make pregnancy possible, but the outcome...
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The role of zinc in follicular development
Follicles consist of specialized somatic cells that encase a single oocyte. Follicle development is a process regulated by a variety of endocrine,...
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An increase of phosphatidylcholines in follicular fluid implies attenuation of embryo quality on day 3 post-fertilization
BackgroundAlthough oocyte quality is the dominant factor determining embryo quality, few studies have been conducted to evaluate embryo quality based...
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Cultured Pig Thyroid Follicular Cells: Electrical Evaluation of Epithelial Integrity
Thyroid epithelial cells organize as enclosed follicles containing thyroid hormone precursor, iodinated thyroglobulin, with lumina bordered by the...
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DNMT1-mediated lncRNA IFFD controls the follicular development via targeting GLI1 by sponging miR-370
DNA methylation and long noncoding RNAs (lncRNAs) exhibit an indispensable role in follicular development. However, the specific mechanisms regarding...
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Bob1 maintains T follicular helper cells for long-term humoral immunity
Humoral immunity is vital for host protection, yet aberrant antibody responses can trigger harmful inflammation and immune-related disorders. T...
