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1. Extracellular adenosine 5ʹ-diphosphate promotes MCP-1/CCL2 expression via the P2Y₁₃ purinergic receptor/ERK signaling axis in temporomandibular joint-derived mouse fibroblast-like synoviocytes

   Background

   Temporomandibular joint osteoarthritis (TMJ-OA) causes cartilage degeneration, bone cavitation, and fibrosis of the TMJ. However, the...

   Seiji Yokota, Naoyuki Chosa, ... Akira Ishisaki in Molecular Biology Reports

   Article Open access 16 December 2022
   

2. Rheumatoid arthritis fibroblast-like synoviocytes maintain tumor-like biological characteristics through ciRS-7-dependent regulation of miR-7

   Background

   Altered phenotype of Fibroblast-like synoviocyte(FLS) is an important cause of the pathogenesis and progression of rheumatoid...

   Zuoyu Hu, **grong Chen, ... Yunfeng Pan in Molecular Biology Reports

   Article 25 June 2022
   

3. Integrins in Pathological Tissue Remodelling of Joints

   Osteoarthritis (OA), a primarily degenerative disorder, and rheumatoid arthritis (RA), a chronic autoimmune inflammatory disease, belong to the most...

   Thomas Pap, Beate Eckes, Adelheid Korb-Pap in Integrins in Health and Disease

   Chapter 2023
   

4. New Therapeutic Strategies for the Inflammatory Rheumatoid Arthritis Disease: Emphasizing Mesenchymal Stem Cells and Associated exo-miRNA or exo-lncRNA

   The most prevalent inflammatory arthritis and a leading contributor to disability is rheumatoid arthritis (RA). Although it may not have arrived in...

   Shadia Faris Ahmed, Saade Abdalkareem Jasim, ... Ahmed Hussein Zwamel in Cell Biochemistry and Biophysics

   Article 31 May 2024
   

5. MiR-92a inhibits fibroblast-like synoviocyte proliferation and migration in rheumatoid arthritis by targeting AKT2

   Growing data have indicated that the miR-17–92 cluster is implicated in inflammatory response and rheumatoid arthritis (RA). This study was aimed to...

   Fang-Yuan Yu, Cong-Qin **e, ... Xun-Wu Huang in Journal of Biosciences

   Article 04 October 2018
   

6. CP-25 inhibits the hyperactivation of rheumatic synoviocytes by suppressing the switch in G_αs-G_αi coupling to the β₂-adrenergic receptor

   In essence, the β ₂ adrenergic receptor (β ₂ AR) plays an antiproliferative role by increasing the intracellular cyclic 3’,5’-adenosine monophosphate...

   Mingli Ge, Li Wu, ... Qingtong Wang in Cell Communication and Signaling

   Article Open access 30 November 2023
   

7. Synovial membrane-derived mesenchymal progenitor cells from osteoarthritic joints in dogs possess lower chondrogenic-, and higher osteogenic capacity compared to normal joints

   Background

   Synovial membrane-derived mesenchymal progenitor cells (SM-MPCs) are a promising candidate for the cell-based treatment of osteoarthritis...

   M. Teunissen, N. S. Ahrens, ... M. A. Tryfonidou in Stem Cell Research & Therapy

   Article Open access 05 September 2022
   

8. Omic horizon expression: a database of gene expression based on RNA sequencing data

   Background

   Gene expression profiles have important significance for gene expression characteristics and further functional studies. More attention has...

   Yuzhe Hu, Dong **e, ... **zhang Wang in BMC Genomics

   Article Open access 08 November 2023
   

9. Long Noncoding RNAs as Therapeutic Targets

   Long noncoding RNAs (lncRNAs) have emerged as critical regulators of cellular functions including maintenance of cellular homeostasis as well as the...

   Jacob B. Pierce, Haoyang Zhou, ... Mark W. Feinberg in Long Noncoding RNA

   Chapter 2022
   

10. The Impact of Non-coding RNA Networks on Disease Comorbidity: Cardiometabolic Diseases, Inflammatory Diseases, and Cancer

    Notably, a cluster of non-coding RNAs is at the cross-road between metabolic and cardiovascular diseases and the cross-road of metabolic diseases and...

    Paul Holvoet in Non-coding RNAs at the Cross-Road of Cardiometabolic Diseases and Cancer

    Chapter 2021
    

11. Mesenchymal Stromal Cell-Based Novel Treatment Modalities in Rheumatoid Arthritis

    Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease that affects the joints’ cartilage lining and can cause considerable pain and...

    Mahtab Ahmadipour, Ahmadreza Jamshidi, ... Massoud Vosough in Handbook of Stem Cell Applications

    Reference work entry 2024
    

12. Extracellular Vesicles: A Potent Therapeutic Tool for Cartilage Regeneration

    Extracellular vesicles (EVs), which mostly include exosomes and microparticles are bilayer lipids that encapsulate nucleic acids and proteins. They...

    Nazmul Huda Syed, Maryam Azlan, ... Asma Abdullah Nurul in Cartilage: From Biology to Biofabrication

    Chapter 2023
    

13. Cellular senescence in skeletal disease: mechanisms and treatment

    The musculoskeletal system supports the movement of the entire body and provides blood production while acting as an endocrine organ. With aging, the...

    Xu He, Wei Hu, ... Qin Shi in Cellular & Molecular Biology Letters

    Article Open access 27 October 2023
    

14. Anti-inflammatory and anti-oxidant activities of mesenchymal stem cells in chemically induced arthritic rats

    Background

    Mesenchymal stem cells (MSCs) have been extensively used as cell-based treatments for decades due to their anti-inflammatory,...

    Mohamed Y. Zaky, Eman E. Mohamed, ... Fatma I. Abo El-Ela in Molecular Biology Reports

    Article 25 October 2023
    

15. Efficacy of IFN-γ-Primed Umbilical Cord-Derived Mesenchymal Stem Cells on Temporomandibular Joint Osteoarthritis

    Background:

    Temporomandibular joint osteoarthritis (TMJOA) is a degenerative disease affecting the cartilage and subchondral bone, leading to...

    Hyunjeong Kim, Yerin Kim, ... Bu-Kyu Lee in Tissue Engineering and Regenerative Medicine

    Article 08 January 2024
    

16. Mesenchymal Stromal Cell-based Novel Treatment Modalities in Rheumatoid Arthritis

    Rheumatoid arthritis (RA) is a systemic chronic inflammatory disease that affects the joints’ cartilage lining and can cause considerable pain and...

    Mahtab Ahmadipour, Ahmadreza Jamshidi, ... Massoud Vosough in Handbook of Stem Cell Applications

    Living reference work entry 2023
    

17. Synovial membrane mesenchymal stem cells for cartilaginous tissues repair

    Background

    The present review is focused on general aspects of the synovial membrane as well as specialized aspects of its cellular constituents,...

    Yessica Zamudio-Cuevas, Ricardo Plata-Rodríguez, ... Carlos Landa-Solís in Molecular Biology Reports

    Article 11 January 2022
    

18. Krüppel-like factor 4 regulates the expression of inducible nitric oxide synthase induced by TNF-α in human fibroblast-like synoviocyte MH7A cells

    Krüppel-like factor 4 (KLF4), a zinc finger transcription factor, has been implicated in the inflammation mediated by macrophages and endothelial...

    Xuanrong Mo, Jie Chen, ... **n**g Luo in Molecular and Cellular Biochemistry

    Article 25 July 2017
    

19. Long Non-coding RNAs in Rheumatology

    The last decade has seen an enormous increase in long non-coding RNA (lncRNA) research within rheumatology. LncRNAs are arbitrarily classed as...

    Susanne N. Wijesinghe, Mark A. Lindsay, Simon W. Jones in Long Noncoding RNA

    Chapter 2022
    

20. Nomenclature clarification: synovial fibroblasts and synovial mesenchymal stem cells

    Synovial-derived cells, found in the synovial membrane of human joints, were obtained by digestion of the synovial membrane and were subsequently...

    Fangqi Li, Yiyong Tang, ... Rui Yang in Stem Cell Research & Therapy

    Article Open access 19 August 2019