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The Technical and Ethical Framework of Fetal Therapy: Past and Current Advances
Purpose of ReviewFetal therapy, a burgeoning field that encompasses prenatal surgical and medical interventions for congenital diseases, enables...
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Microtubule-Targeting Agents: Disruption of the Cellular Cytoskeleton as a Backbone of Ovarian Cancer Therapy
Microtubules are dynamic polymers composed of α- and β-tubulin heterodimers. Microtubules are universally conserved among eukaryotes and participate...
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Fetal Muse-based therapy prevents lethal radio-induced gastrointestinal syndrome by intestinal regeneration
BackgroundHuman multilineage-differentiating stress enduring (Muse) cells are nontumorigenic endogenous pluripotent-like stem cells that can be...
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Transcriptomic and proteomic profiles of fetal versus adult mesenchymal stromal cells and mesenchymal stromal cell-derived extracellular vesicles
BackgroundMesenchymal stem/stromal cells (MSCs) can regenerate tissues through engraftment and differentiation but also via paracrine signalling via...
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Presence of onco-fetal neighborhoods in hepatocellular carcinoma is associated with relapse and response to immunotherapy
Onco-fetal reprogramming of the tumor ecosystem induces fetal developmental signatures in the tumor microenvironment, leading to immunosuppressive...
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The regulated cell death at the maternal-fetal interface: beneficial or detrimental?
Regulated cell death (RCD) plays a fundamental role in placental development and tissue homeostasis. Placental development relies upon effective...
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Multipotent fetal stem cells in reproductive biology research
Due to the limited accessibility of the in vivo situation, the scarcity of the human tissue, legal constraints, and ethical considerations, the...
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Placenta-targeted Treatment Strategies for Preeclampsia and Fetal Growth Restriction: An Opportunity and Major Challenge
The placenta plays a crucial role in maintaining normal pregnancy. The failure of spiral artery remodeling (SAR) is a key factor leading to placental...
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TRASCET—Transamniotic Stem Cell Therapy
Purpose of ReviewThis is an overview of the current state of development of transamniotic stem cell therapy (TRASCET) as an emerging therapeutic...
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Structural surfaceomics reveals an AML-specific conformation of integrin β2 as a CAR T cellular therapy target
Safely expanding indications for cellular therapies has been challenging given a lack of highly cancer-specific surface markers. Here we explore the...
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3-Deazaadenosine alleviates senescence to promote cellular fitness and cell therapy efficiency in mice
Cellular senescence is a stable type of cell cycle arrest triggered by different stresses. As such, senescence drives age-related diseases and curbs...
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Chromatin accessibility and H3K9me3 landscapes reveal long-term epigenetic effects of fetal-neonatal iron deficiency in rat hippocampus
BackgroundIron deficiency (ID) during the fetal-neonatal period results in long-term neurodevelopmental impairments associated with pervasive...
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Liposome-Encapsulated Anti-inflammatory Proteins for Targeted Delivery to the Placenta to Treat Fetal Growth Restriction
Fetal growth restriction (FGR), the failure of a fetus to reach its genetically determined growth potential, is a serious complication affecting up...
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Cellular senescence triggers intracellular acidification and lysosomal pH alkalinized via ATP6AP2 attenuation in breast cancer cells
Several chemotherapeutic drugs induce senescence in cancer cells; however, the mechanisms underlying intracellular pH dysregulation in senescent...
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Stem Cell-Based Regenerative Medicine Therapy in Cancer
Stem cells play a unique role in various stages of an organism’s life cycle. Intensive research on the biology of stem cells has demystified many...
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Prenatal Therapy for Congenital Diaphragmatic Hernia and Myelomeningocele: Advances in Particle-Based Delivery
Purpose of ReviewPrenatal intervention for congenital diseases could potentially halt or reverse devastating co-morbidities. Particle-based therapy...
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Xenogeneic and Allogenic Cellular Rejection (CR)
In solid organ xenotransplantation, the humoral response of human immunity is a direct barrier due to its Abs binding to non-self-antigens of...
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TRIM22 induces cellular senescence by targeting PHLPP2 in hepatocellular carcinoma
The ubiquitin-proteasome system is a vital protein degradation system that is involved in various cellular processes, such as cell cycle progression,...
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Biomechanics of circulating cellular and subcellular bioparticles: beyond separation
Biomechanical attributes have emerged as novel markers, providing a reliable means to characterize cellular and subcellular fractions. Numerous...
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The miR-30-5p/TIA-1 axis directs cellular senescence by regulating mitochondrial dynamics
Senescent cells exhibit a diverse spectrum of changes in their morphology, proliferative capacity, senescence-associated secretory phenotype (SASP)...
