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Targeted and whole-genome sequencing reveal a north-south divide in P. falciparum drug resistance markers and genetic structure in Mozambique
Mozambique is one of the four African countries which account for over half of all malaria deaths worldwide, yet little is known about the parasite...
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Drug resistance and vaccine target surveillance of Plasmodium falciparum using nanopore sequencing in Ghana
Malaria results in over 600,000 deaths annually, with the highest burden of deaths in young children living in sub-Saharan Africa. Molecular...
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Positive-unlabeled learning identifies vaccine candidate antigens in the malaria parasite Plasmodium falciparum
Malaria vaccine development is hampered by extensive antigenic variation and complex life stages of Plasmodium species. Vaccine development has...
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Plasmodium falciparum gametocytes display global chromatin remodelling during sexual differentiation
BackgroundThe protozoan malaria parasite Plasmodium falciparum has a complex life cycle during which it needs to differentiate into multiple...
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Crucifer’s Pathogens Genome
The information on genome sequences, analysis and assembly of limited pathogens of crucifers has been generated and made available. It has given...
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Plasmodium falciparum resistant to artemisinin and diagnostics have emerged in Ethiopia
Diagnosis and treatment of Plasmodium falciparum infections are required for effective malaria control and are pre-requisites for malaria elimination...
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A type II protein arginine methyltransferase regulates merozoite invasion in Plasmodium falciparum
Protein arginine methyltransferases (PRMTs) regulate many important cellular processes, such as transcription and RNA processing in model organisms...
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Genome-Wide Ribosome Profiling of the Plasmodium falciparum Intraerythrocytic Developmental Cycle
Monitoring whole-genome translation and mRNA ribosome occupancy in vivo using ribosome profiling has proven to be a powerful tool for discovery of...
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A manually curated annotation characterises genomic features of P. falciparum lncRNAs
BackgroundImportant regulation occurs at the level of transcription in Plasmodium falciparum and growing evidence suggests that these apicomplexan...
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A versatile Plasmodium falciparum reporter line expressing NanoLuc enables highly sensitive multi-stage drug assays
Transgenic luciferase-expressing Plasmodium falciparum parasites have been widely used for the evaluation of anti-malarial compounds. Here, to screen...
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Large DNA fragment knock-in and sequential gene editing in Plasmodium falciparum: a preliminary study using suicide-rescue-based CRISPR/Cas9 system
CRISPR/Cas9 technology applied to Plasmodium falciparum offers the potential to greatly improve gene editing, but such expectations including large...
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Genoty** var Gene DBL1α Domain of Severe and Non-severe Plasmodium falciparum Patients
This study analysed the genetic diversity of DBL1α domain of Plasmodium falciparum var gene in severe and non-severe malaria patients from Delhi and...
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Adipokinetic hormone signaling in the malaria vector Anopheles gambiae facilitates Plasmodium falciparum sporogony
An obligatory step in the complex life cycle of the malaria parasite is sporogony, which occurs during the oocyst stage in adult female Anopheles ...
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tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum
Plasmodium falciparum artemisinin (ART) resistance is driven by mutations in kelch-like protein 13 (PfK13). Quiescence, a key aspect of resistance,...
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Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1
Malaria parasites break down host haemoglobin into peptides and amino acids in the digestive vacuole for export to the parasite cytoplasm for growth:...
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Characterising genome architectures using genome decomposition analysis
Genome architecture describes how genes and other features are arranged in genomes. These arrangements reflect the evolutionary pressures on genomes...
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Structure-based virtual screening against multiple Plasmodium falciparum kinases reveals antimalarial compounds
The continuous emergence of resistance against most frontline antimalarial drugs has led to countless deaths in malaria-endemic countries, counting...
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Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response
The emergence and spread of artemisinin-resistant Plasmodium falciparum , first in the Greater Mekong Subregion (GMS), and now in East Africa, is a...
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STRIDE: a command-line HMM-based identifier and sub-classifier of Plasmodium falciparum RIFIN and STEVOR variant surface antigen families
BackgroundRIFINs and STEVORs are variant surface antigens expressed by P. falciparum that play roles in severe malaria pathogenesis and immune...
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Comparative analysis of the kinomes of Plasmodium falciparum, Plasmodium vivax and their host Homo sapiens
BackgroundNovel antimalarials should be effective across all species of malaria parasites that infect humans, especially the two species that bear...
