Search
Search Results
-
Deletion of FGF9 in GABAergic neurons causes epilepsy
Fibroblast growth factor 9 (FGF9) has long been assumed to modulate multiple biological processes, yet very little is known about the impact of FGF9...
-
Zbtb33 Gene Knockout Changes Transcription of the Fgf9, Fgfr3, c-Myc and FoxG1 Genes in the Develo** Mouse Brain
AbstractThe transcription factor KAISO is important for proper development of animal embryos. In the cell, KAISO regulates cell division and...
-
FGF-independent MEK1/2 signalling in the develo** foetal testis is essential for male germline differentiation in mice
BackgroundDisrupted germline differentiation or compromised testis development can lead to subfertility or infertility and are strongly associated...
-
LncRNA H19 promotes odontoblastic differentiation of human dental pulp stem cells by regulating miR-140-5p and BMP-2/FGF9
BackgroundIncreasing evidence has revealed that long non-coding RNAs (lncRNAs) exert critical roles in biological mineralization. As a critical...
-
Fibroblast growth factor 9 attenuates sepsis-induced fulminant hepatitis in mice
Sepsis-induced fulminant hepatitis (FH) is a fatal syndrome that has a worse prognosis in clinical practice. Hence, seeking effective agents for...
-
In vitro effects of two environmental toxicants, beauvericin and glyphosate in Roundup, on cell numbers and steroidogenesis of bovine ovarian cells
Beauvericin is an emerging Fusariotoxin naturally occurring in cereal grains throughout the world whereas glyphosate (N-phosphonomethyl-glycine) is a...
-
Novel six-gene prognostic signature based on colon adenocarcinoma immune-related genes
BackgroundColon adenocarcinoma (COAD) is one of the most common gastrointestinal tumors worldwide, and immunotherapy is one of the most promising...
-
Identification of candidate genomic regions for egg yolk moisture content based on a genome-wide association study
BackgroundEggs represent important sources of protein and are widely loved by consumers. Egg yolk taste is an important index for egg selection, and...
-
Podocytes derived from human induced pluripotent stem cells: characterization, comparison, and modeling of diabetic kidney disease
BackgroundIn diabetic kidney disease, high glucose damages specialized cells called podocytes that filter blood in the glomerulus. In vitro culture...
-
Inhibition of WNT/β-catenin signalling during sex-specific gonadal differentiation is essential for normal human fetal testis development
Sex-specific gonadal differentiation is directed by complex signalling promoting development in either male or female direction, while simultaneously...
-
Neurotrophic Biomarkers
Neurotrophins are proteins that exert profound effects on cell survival and activity within the central nervous system, playing crucial roles in the...
-
Human endometrium-derived stem cell improves cardiac function after myocardial ischemic injury by enhancing angiogenesis and myocardial metabolism
BackgroundThe human endometrium in premenopausal women is an active site of physiological angiogenesis, with regenerative cells present, suggesting...
-
Generation of proximal tubule-enhanced kidney organoids from human pluripotent stem cells
Kidney organoids derived from human pluripotent stem cells (hPSCs) are now being used as models of renal disease and nephrotoxicity screening....
-
Galectins use N-glycans of FGFs to capture growth factors at the cell surface and fine-tune their signaling
Fibroblast growth factors (FGFs) and their receptors (FGFRs) constitute complex signaling hubs that are crucial for the development and homeostasis...
-
Pharmaceutically Important Fungal Endophytes Associated with Mushrooms: Current Findings and Prospects
Traditional medication knowledge base has propelled the pharma sector to actively look into natural bioactive. Apart from various plants, certain...
-
HIF-1α promotes kidney organoid vascularization and applications in disease modeling
BackgroundKidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease modeling, and cell...
-
Gene expression of male pathway genes sox9 and amh during early sex differentiation in a reptile departs from the classical amniote model
BackgroundSex determination is the process whereby the bipotential embryonic gonads become committed to differentiate into testes or ovaries. In...
-
Estrogen suppresses SOX9 and activates markers of female development in a human testis-derived cell line
BackgroundThe increasing incidence of reproductive disorders in humans has been attributed to in utero exposure to estrogenic endocrine disruptors....
-
Sex difference on fibroblast growth factors (FGFs) expression in skin and wound of streptozotocin(STZ)-induced type 1 diabetic mice
BackgroundFibroblast growth factors (FGFs) are key factors affecting diabetic wound healing. However, the FGF family’s expression patterns in skin...
-
SOX9 in organogenesis: shared and unique transcriptional functions
The transcription factor SOX9 is essential for the development of multiple organs including bone, testis, heart, lung, pancreas, intestine and...
