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Capability of DHA biosynthesis in a marine teleost, Pacific saury Cololabis saira: functional characterization of two paralogous Fads2 desaturases and Elovl5 elongase
The Pacific saury Cololabis saira is an important fishery resource in the Far East, where it is appreciated for its high lipid content, which...
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The role of fatty acid desaturase 2 in multiple tumor types revealed by bulk and single-cell transcriptomes
BackgroundPrevious studies have demonstrated the important role of fatty acid desaturase 2 (FADS2) in governing tumorigenesis and tumor metastasis....
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Determination of dietary essential fatty acids in a deep-sea fish, the splendid alfonsino Beryx splendens: functional characterization of enzymes involved in long-chain polyunsaturated fatty acid biosynthesis
The splendid alfonsino Beryx splendens is a commercially important deep-sea fish in East Asian countries. Because the wild stock of this species has...
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Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production
Highly unsaturated fatty acids (HUFAs) are fatty acids with more than three double bonds in the molecule. Mammalian testes contain very high levels...
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Preparing for the future offspring: European perch (Perca fluviatilis) biosynthesis of physiologically required fatty acids for the gonads happens already in the autumn
Long-chain polyunsaturated fatty acids (PUFA) are critical for reproduction and thermal adaptation. Year-round variability in the expression of fads2 ...
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Engineered human hepatocyte organoids enable CRISPR-based target discovery and drug screening for steatosis
The lack of registered drugs for nonalcoholic fatty liver disease (NAFLD) is partly due to the paucity of human-relevant models for target discovery...
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A complete inventory of long-chain polyunsaturated fatty acid biosynthesis pathway enzymes in the miniaturized cyprinid Paedocypris micromegethes
The capacity for long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis activity in a species depends on the enzymatic activities of fatty...
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Role of plasma fatty acid in age-related macular degeneration: insights from a mendelian randomization analysis
BackgroundAn imbalance in lipid metabolism has been linked to the development of AMD, but the causal relationship between AMD and plasma fatty acids...
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Human liver organoid: modeling liver steatosis and beyond
Steatosis, as the early stage of nonalcoholic fatty acid disease (NAFLD), would progress into nonalcoholic steatohepatitis (NASH) and liver failure...
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Transcriptome analysis of large yellow croaker (Larimichthys crocea) at different growth rates
The unsynchronized growth of the large yellow croaker ( Larimichthys crocea ), which impacts growth efficiency, poses a challenge for aquaculture...
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Effect of fasting and refeeding on serum physiology, intestinal microbiota, and transcriptome in Pseudobagrus vachellii
Fasting is a common phenomenon caused by environmental factors. Here, changes in growth, serum biochemical parameters, intestinal microbiota, and...
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Inhibition of cannabinoid receptor type 1 sensitizes triple-negative breast cancer cells to ferroptosis via regulating fatty acid metabolism
Triple-negative breast cancer (TNBC) is a heterogeneous subtype of breast cancer that displays highly aggressive with poor prognosis. Owing to the...
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Rumen microbial-driven metabolite from grazing lambs potentially regulates body fatty acid metabolism by lipid-related genes in liver
BackgroundLipid metabolism differs significantly between grazing and stall-feeding lambs, affecting the quality of livestock products. As two...
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Dysregulated palmitic acid metabolism promotes the formation of renal calcium-oxalate stones through ferroptosis induced by polyunsaturated fatty acids/phosphatidic acid
The pathogenesis of renal calcium-oxalate (CaOx) stones is complex and influenced by various metabolic factors. In parallel, palmitic acid (PA) has...
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Lack of ∆5 Desaturase Activity Impairs EPA and DHA Synthesis in Fish Cells from Red Sea Bream and Japanese Flounder
Long-chain (≥ C 20 ) polyunsaturated fatty acids (LC-PUFA), such as eicosapentaenoic acid (20:5n-3, EPA) and docosahexaenoic acid (22:6n-3, DHA), are...
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Metabolomics and transcriptomics based multi-omics integration reveals radiation-induced altered pathway networking and underlying mechanism
Recent advancement in integrated multi-omics has significantly contributed to many areas of the biomedical field. Radiation research has also grasped...
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Impact of High-Sucrose Diet on the mRNA Levels for Elongases and Desaturases and Estimated Protein Activity in Rat Adipose Tissue
AbstractFatty acids (FAs) present in the adipose tissue (AT) can be modified by elongases and desaturases. These enzymes are regulated by different...
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Ancestry-related distribution of Runs of homozygosity and functional variants in Qatari population
BackgroundDescribing how genetic history shapes the pattern of medically relevant variants could improve the understanding of how specific loci...
