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Progress and challenges of develo** volatile metabolites from exhaled breath as a biomarker platform
BackgroundThe multitude of metabolites generated by physiological processes in the body can serve as valuable biomarkers for many clinical purposes....
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New perspectives on ‘Breathomics’: metabolomic profiling of non-volatile organic compounds in exhaled breath using DI-FT-ICR-MS
Breath analysis offers tremendous potential for diagnostic approaches, since it allows for easy and non-invasive sample collection. “Breathomics” as...
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Exhaled Breath Condensate Study for Biomarkers Discovery
Biomarkers seem to play an important role in understanding various diseases’ nature, course and management, including respiratory ones. Yet,...
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Proteomic characteristics and diagnostic potential of exhaled breath particles in patients with COVID-19
BackgroundSARS-CoV-2 has been shown to predominantly infect the airways and the respiratory tract and too often have an unpredictable and different...
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Identifying potential breath biomarkers for early diagnosis of papillary thyroid cancer based on solid-phase microextraction gas chromatography-high resolution mass spectrometry with metabolomics
IntroductionThyroid cancer incidence rate has increased substantially worldwide in recent years. Fine needle aspiration biopsy (FNAB) is currently...
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Origin of breath isoprene in humans is revealed via multi-omic investigations
Plants, animals and humans metabolically produce volatile isoprene (C 5 H 8 ). Humans continuously exhale isoprene and exhaled concentrations differ...
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Putative volatile biomarkers of bovine tuberculosis infection in breath, skin and feces of cattle
Bovine tuberculosis (bTB) is an infectious disease with significant impact on animal health, public health and international trade. Standard bTB...
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Selected ion flow tube mass spectrometry for targeted analysis of volatile organic compounds in human breath
The analysis of volatile organic compounds (VOCs) within breath for noninvasive disease detection and monitoring is an emergent research field that...
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Circadian Metabolomics from Breath
Metabolites like melatonin are essential in determining circadian phase. In the recent years, comprehensive metabolome analyses have unveiled entire...
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Intranasal PAMAM-G3 scavenges cell-free DNA attenuating the allergic airway inflammation
Allergic airway inflammation (AAI), including allergic rhinitis (AR) and allergic asthma, is driven by epithelial barrier dysfunction and type 2...
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Exploring Liver Mitochondrial Function by 13C-Stable Isotope Breath Tests: Implications in Clinical Biochemistry
The liver is at the crossroad of key metabolic processes, which include detoxification, glycolipidic storage and export, and protein synthesis. The...
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Subty** irritable bowel syndrome using cluster analysis: a systematic review
BackgroundIrritable bowel syndrome (IBS) is a common chronic functional gastrointestinal disorder associated with a wide range of clinical symptoms....
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A novel non-invasive method allowing for discovery of pathologically relevant proteins from small airways
BackgroundThere is a lack of early and precise biomarkers for personalized respiratory medicine. Breath contains an aerosol of droplet particles,...
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Metabolomics: From Scientific Research to the Clinical Diagnosis
Metabolomics supports uncovering relevant pathophysiological mechanisms and identifying biomarkers of risk and progression in diseases. Furthermore,...
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Identification of novel metabolic signatures potentially involved in the pathogenesis of COPD associated pulmonary hypertension
IntroductionChronic obstructive pulmonary disease (COPD) associated pulmonary hypertension (COPD-PH), one of the most prevalent forms of PH, is a...
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Advances in Three-Dimensional Metal Oxide-Based Nanostructures for Biological Gas-Sensing Applications
Nanostructured materials have been widely studied and established for various sensing applications in the last few decades. Nevertheless, there are...
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Fabricating and printing chemiresistors based on monolayer-capped metal nanoparticles
Chemiresistors that are based on monolayer-capped metal nanoparticles (MCNPs) have been used in a wide variety of innovative sensing applications,...
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Canine Detection of Cancer in Humans: Expectations Versus Reality
Easily accessible screening methods play a crucial role in the early detection of cancer. Over the last few decades, alternative cancer screening...
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Is there a placental microbiota? A critical review and re-analysis of published placental microbiota datasets
The existence of a placental microbiota is debated. The human placenta has historically been considered sterile and microbial colonization was...
