Search
Search Results
-
Expression and Characterization of a Potent Long-Acting GLP-1 Receptor Like Agonist, Exendin-4-Fc
Human GLP-1 (glucagon-like peptide-1) can produce a remarkable improvement in glycemic control in patients with type 2 diabetes. However, its...
-
Exendin-4 and eldecalcitol synergistically promote osteogenic differentiation of bone marrow mesenchymal stem cells through M2 macrophages polarization via PI3K/AKT pathway
BackgroundThe incidence of diabetic osteoporosis is increasing. This article evaluates the effect of combination treatment with the hypoglycemic drug...
-
Oral self-nanoemulsifying formulation of GLP-1 agonist peptide exendin-4: development, characterization and permeability assesment on Caco-2 cell monolayer
The objective of this study was to prepare a stable self-nanoemulsifying formulation of exendin-4, which is an antidiabetic peptide. As exendin-4 is...
-
Human GLP1R variants affecting GLP1R cell surface expression are associated with impaired glucose control and increased adiposity
The glucagon-like peptide 1 receptor (GLP1R) is a major drug target with several agonists being prescribed in individuals with type 2 diabetes and...
-
Renal effects of exendin-4 in an animal model of brain death
Organ transplantation is the gold standard therapy for the majority of patients with terminal organ failure. However, it is still a limited treatment...
-
Secretome-based screening of fusion partners and their application in recombinant protein secretion in Saccharomyces cerevisiae
AbstractFor the efficient production of heterologous proteins in the yeast Saccharomyces cerevisiae , we screened for a novel fusion partner from the...
-
Dipeptidyl peptidase 4 promotes peritoneal fibrosis and its inhibitions prevent failure of peritoneal dialysis
Peritoneal dialysis (PD) possesses multiple advantages for end stage renal disease. However, long-term PD triggers peritoneal fibrosis (PF). From the...
-
Activation of arcuate nucleus glucagon-like peptide-1 receptor-expressing neurons suppresses food intake
BackgroundCentral nervous system (CNS) control of metabolism plays a pivotal role in maintaining energy balance. In the brain, Glucagon-like peptide...
-
-
Vitamin D supplementation affects bone marrow-derived mesenchymal stem cells differentiation into insulin-producing cells
Background this study was conducted to assess the effects of vitamin D on differentiation of bone marrow- derived mesenchymal stem cells (BM-MSCs)...
-
Treatment of type 2 diabetes mellitus with stem cells and antidiabetic drugs: a dualistic and future-focused approach
Type 2 Diabetes Mellitus (T2DM) accounts for more than 90% of total diabetes mellitus cases all over the world. Obesity and lack of balance between...
-
Optimization of differentiation protocols of dental tissues stem cells to pancreatic β-cells
BackgroundDespite the recent progress in the differentiation strategies of stem cells into pancreatic beta cell lineage, current protocols are not...
-
In vitro expansion of pancreatic islet clusters facilitated by hormones and chemicals
Tissue regeneration, such as pancreatic islet tissue propagation in vitro, could serve as a promising strategy for diabetes therapy and personalised...
-
GRP94 is an IGF-1R chaperone and regulates beta cell death in diabetes
High workload-induced cellular stress can cause pancreatic islet β cell death and dysfunction, or β cell failure, a hallmark of type 2 diabetes...
-
Current Status of Therapeutic Peptides for the Management of Diabetes Mellitus
Diabetes mellitus (DM) is a chronic endocrine disorder with lifelong implications. The prevalence of this condition is steadily increasing,...
-
Minimal SC-β-Cell Properties for Transplantation in Diabetic Patients
Pancreatic β cells within the islets of Langerhans are the body’s main source for insulin. β cells maintain glucose homeostasis through the tight...
-
The gut microbiota modulate locomotion via vagus-dependent glucagon-like peptide-1 signaling
Locomotor activity is an innate behavior that can be triggered by gut-motivated conditions, such as appetite and metabolic condition. Various...
-
Functional, metabolic and transcriptional maturation of human pancreatic islets derived from stem cells
Transplantation of pancreatic islet cells derived from human pluripotent stem cells is a promising treatment for diabetes. Despite progress in the...
-
Optimizing Generation of Stem Cell-Derived Islet Cells
Islet transplantation is a highly effective treatment for select patients with type 1 diabetes. Unfortunately, current use is limited to those with...
-
Dried Blood Spot Sampling in Protein and Peptide Bioanalysis: Optimism, Experience, and the Path Forward
Dried blood spot (DBS) based microsampling is an emerging approach that requires a minimally invasive procedure. It is being increasingly used in...
