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One-Shot Generation of Epitope-Directed Monoclonal Antibodies to Multiple Nonoverlap** Targets: Peptide Selection, Antigen Preparation, and Epitope Map**
This chapter describes an epitope-directed approach to generate antipeptide monoclonal antibodies to multiple nonoverlap** protein sites using a...
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Conformational epitope matching and prediction based on protein surface spiral features
BackgroundA conformational epitope (CE) is composed of neighboring amino acid residues located on an antigenic protein surface structure. CEs bind...
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Immunogenic Epitope-Based Vaccine Prediction from Surface Glycoprotein of MERS-CoV by Deploying Immunoinformatics Approach
Middle East respiratory syndrome coronavirus (MERS-CoV) has caused a high mortality rate since its emergence in 2012 in the Middle East. Currently,...
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Phylogenetic analysis and antigenic epitope prediction for E6 and E7 of Alpha-papillomavirus 9 in Taizhou, China
BackgroundAlpha-papillomavirus 9 (α-9) is a member of the human papillomavirus (HPV) α genus, causing 75% invasive cervical cancers worldwide. The...
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Multiple circulating forms of neprilysin detected with novel epitope-directed monoclonal antibodies
Neprilysin (NEP) is an emerging biomarker for various diseases including heart failure (HF). However, major inter-assay inconsistency in the reported...
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An Immunoinformatics Prediction of Novel Multi-Epitope Vaccines Candidate Against Surface Antigens of Nipah Virus
Nipah virus (NiV) is an emerging zoonotic virus causing outbreaks of encephalitis and respiratory illnesses in humans, with high mortality. NiV is...
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Designing multi-epitope vaccine against important colorectal cancer (CRC) associated pathogens based on immunoinformatics approach
BackgroundIt seems that several members of intestinal gut microbiota like Streptococcus bovis, Bacteroides fragilis, Helicobacter pylori,...
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A novel epitope tag from rabies virus has versatile in vitro applications
AbstractFusion tag technology is an important tool for rapid separation, purification, and characterization of proteins. Combined with monoclonal...
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Mammalian cell display with automated oligo design and library assembly allows for rapid residue level conformational epitope map**
Precise epitope determination of therapeutic antibodies is of great value as it allows for further comprehension of mechanism of action, therapeutic...
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Novel edible multi-epitope vaccine construct against Enterococcus faecalis
Enterococcus faecalis is an opportunistic pathogen known to cause urinary tract and gastrointestinal infection in addition to bacteraemia,...
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A novel conserved B-cell epitope in pB602L of African swine fever virus
AbstractAfrican swine fever virus (ASFV) is a complex DNA virus and the only member of the Asfarviridae family. It causes high mortality and severe...
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Identification of a novel linear B-cell epitope in porcine deltacoronavirus nucleocapsid protein
AbstractPorcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus that caused diarrhea and/or vomiting in neonatal piglets...
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In silico designing of novel epitope-based peptide vaccines against HIV-1
AbstractThe HIV-1 virus has been regarded as a catastrophe for human well-being. The global incidence of HIV-1-infected individuals is increasing....
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The use of Bacillus subtilis as a cost-effective expression system for production of Cholera Toxin B fused factor VIII epitope regions applicable for inducing oral immune tolerance
Coagulation factor replacement therapy for the X-linked bleeding disorder Haemophilia, characterized by a deficiency of coagulation protein factor...
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Advances in Computational and Bioinformatics Tools and Databases for Designing and Develo** a Multi-Epitope-Based Peptide Vaccine
A vaccine is defined as a biologic preparation that trains the immune system, boosts immunity, and protects against a deadly microbial infection....
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Immunoinformatics design of multi-epitope vaccine using OmpA, OmpD and enterotoxin against non-typhoidal salmonellosis
BackgroundNon-typhoidal Salmonella (NTS) is one of the important bacteria that cause foodborne diseases and invasive infections in children and...
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In silico Approach for B Cell Epitopes Prediction of Respiratory Syncytial Virus
In recent years, epitope-based peptides have constituted a prominent and prospective class in pharmacology; especially in mounting specific immune...
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Immunoinformatics design of novel multi-epitope vaccine against Trueperella Pyogenes using collagen adhesion protein, fimbriae, and pyolysin
Trueperella pyogenes ( T. pyogenes ) is an opportunistic pathogen that causes infertility, mastitis, and metritis in animals. T. pyogenes is also a...
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“Redirecting an anti-IL-1β antibody to bind a new, unrelated and computationally predicted epitope on hIL-17A”
Antibody engineering technology is at the forefront of therapeutic antibody development. The primary goal for engineering a therapeutic antibody is...
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Exploring the surface epitope and nuclear localization analysis of porcine circovirus type 3 capsid protein
Porcine circovirus 3 (PCV3) is a newly emerging virus associated with porcine dermatitis and nephropathy syndrome (PDNS) and reproductive disorders,...
