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Investigating Epidermal Growth Factor Receptor Trafficking with High-Resolution Enzymatic Protein-Tagging and Transmission Electron Microscopy
Enzymatic ascorbate peroxidase (APEX) tagging allows for high-resolution, three-dimensional protein distribution analyses in cells and tissues. This...
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Human epidermal growth factor receptor 3 serves as a novel therapeutic target for acral melanoma
Acral melanoma (AM) is a rare, life-threatening skin cancer. Since AM bears unique features, existing therapies for other types of malignant...
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Human epidermal growth factor receptor 2 (HER2)-specific chimeric antigen receptor (CAR) for tumor immunotherapy; recent progress
Due to the overexpression or amplification of human epidermal growth factor receptor 2 (HER2) with poor prognosis in a myriad of human tumors, recent...
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Design and construction of scFv-PE35KDEL as a novel immunotoxin against human epidermal growth factor receptor 2 for cancer therapy
ProposeHuman epidermal growth factor receptor 2 (HER2) is overexpressed on the surface of some kinds of cancer cells including breast cancer. In this...
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A homogalacturonan from Lonicera japonica Thunb. disrupts angiogenesis via epidermal growth factor receptor and Delta-like 4 associated signaling
A homogeneous polysaccharide named as LJW2F2 was extracted and purified from the flowers of Lonicera japonica Thunb. Structural characteristic...
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Circadian patterns of growth factor receptor-dependent signaling and implications for carcinogenesis
Several different signaling pathways that regulate cell proliferation and differentiation are initiated by binding of ligands to cell-surface and...
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An association of epidermal growth factor receptor mutation subtypes with prognostic prediction and site-specific recurrence in advanced stage lung cancer patients
BackgroundConcerning the different clinical behavior of epidermal growth factor receptor (EGFR) subtypes in advanced-stage lung cancer patients, the...
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Two missense variants of the epidermal growth factor receptor gene are associated with non small cell lung carcinoma in the subjects from Iraq
BackgroundLung carcinoma is a foremost cause of cancer-related mortality worldwide. Variable genetic factors are associated with the development of...
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Protein kinase D1 overexpression potentiates epidermal growth factor signaling pathway in MCF-7 cells
BackgroundProtein kinase D1, PKD1, is a serine-threonine kinase implicated in cell proliferation, migration, invasion, and/or apoptosis and its...
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Osteoclast-derived extracellular vesicles are implicated in sensory neurons sprouting through the activation of epidermal growth factor signaling
BackgroundDifferent pathologies, affecting the skeletal system, were reported to display altered bone and/or cartilage innervation profiles leading...
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Milk fat-globule epidermal growth factor 8: A potential Regulator of Cutaneous Wound Healing
Destroying the integrity of the skin may causes disability and even death from injury or illness. Wound healing is a core mechanism to maintain skin...
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Utilization of Freeze-Thawing Method for High-level Expression of Functional Human Epidermal Growth Factor (hEGF)
The wide applications of human epidermal growth factor (hEGF) as an efficient mitogen agent in the clinical, health, and cosmetic industries has made...
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Epidermal Growth Factor Receptor: Key to Selective Intracellular Delivery
AbstractEpidermal growth factor receptor (EGFR) is an integral surface protein mediating cellular response to a number of growth factors. Its...
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Synergy of epidermal growth factor (EGFR) and angiotensin II (AT1R) receptor determines composition and temporal pattern of transcriptome variation
The tyrosine kinase receptor EGFR and the G-protein-coupled receptor AT1R induce essential cellular responses, in part via receptor crosstalk with an...
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Rapid Screening for High Expressing Multicopy Recombinants and Enhanced Epidermal Growth Factor (EGF) Protein Production Using Pichia Pastoris
Epidermal growth factor (EGF) is a highly effective stimulator which promotes cell proliferation and this has led it to being proposed as a...
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CG6015 controls spermatogonia transit-amplifying divisions by epidermal growth factor receptor signaling in Drosophila testes
Spermatogonia transit-amplifying (TA) divisions are crucial for the differentiation of germline stem cell daughters. However, the underlying...
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IL-26 mediates epidermal growth factor receptor-tyrosine kinase inhibitor resistance through endoplasmic reticulum stress signaling pathway in triple-negative breast cancer cells
Triple-negative breast cancer (TNBC) has a poor prognosis compared to other breast cancer subtypes. Although epidermal growth factor receptor (EGFR)...
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Matrix metalloproteinase-10 protects against acute kidney injury by augmenting epidermal growth factor receptor signaling
Matrix metalloproteinase-10 (MMP-10) is a zinc-dependent endopeptidase involved in regulating a wide range of biologic processes, such as apoptosis,...
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Generation of Properly Folded Epidermal Growth Factor-Like (EGF) Repeats and Glycosyltransferases Enables In Vitro O-Glycosylation
The epidermal growth factor-like (EGF) domain is an evolutionarily conserved motif found widely distributed among numerous secreted and...
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The SlSHN2 transcription factor contributes to cuticle formation and epidermal patterning in tomato fruit
Tomato ( Solanum lycopersicum ) is an established model for studying plant cuticle because of its thick cuticle covering and embedding the epidermal...
