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CRISPR Interference (CRISPRi) Mediated Suppression of OmpR Gene in E. coli: An Alternative Approach to Inhibit Biofilm
Biofilm plays an important role in the community and hospital-acquired infections. Especially E. coli biofilm that contributes towards the...
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Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles
Antibiotic resistance is a pressing healthcare challenge and is mediated by various mechanisms, including the active export of drugs via multidrug...
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Synthesis and biochemical characterization of naphthoquinone derivatives targeting bacterial histidine kinases
Waldiomycin is an inhibitor of histidine kinases (HKs). Although most HK inhibitors target the ATP-binding region, waldiomycin binds to the...
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Molecular mechanism of siderophore regulation by the Pseudomonas aeruginosa BfmRS two-component system in response to osmotic stress
Pseudomonas aeruginosa , a common nosocomial pathogen, relies on siderophores to acquire iron, crucial for its survival in various environments and...
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Engineering Whole-Cell Biosensors for Enhanced Detection of Environmental Antibiotics Using a Synthetic Biology Approach
Bacterial Two component systems have evolved with many intricate sensory apparatuses for external stimuli like light, temperature, oxygen, pH and...
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Genomic insights into the molecular mechanisms of a Pseudomonas strain significant in its survival in Kongsfjorden, an Arctic fjord
Whole-genome sequence of Pseudomonas sp. Kongs-67 retrieved from Kongsfjorden, an Arctic fjord, has been investigated to understand the molecular...
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Sensors of abiotic stress in Synechocystis
Systematic mutagenesis of histidine kinases in combination with DNA microarray technology has allowed us to identify sensors for cold, hyperosmotic...
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Salmonella Typhimurium O-antigen and VisP play an important role in swarming and osmotic stress response during intracellular conditions
Salmonella Typhimurium is a pathogen of clinical relevance and a model of study in host–pathogen interactions. The virulence and stress-related...
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Determining the potential targets of silybin by molecular docking and its antibacterial functions on efflux pumps and porins in uropathogenic E. coli
BackgroundOne of the causes of antibiotic resistance is the reduced accumulation of antibiotics in bacterial cells through pum** out the drugs....
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What do we know about osmoadaptation of Yersinia pestis?
The plague agent Yersinia pestis mainly spreads among mammalian hosts and their associated fleas. Production of a successful mammal–flea–mammal life...
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The role of histidine kinase signalling in response to salt stress
Salt stress is a global environmental problem, which affects various biochemical and physiological processes in plants and significantly decreases...
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Production of ammonia as a low-cost and long-distance antibiotic strategy by Streptomyces species
Soil-inhabiting streptomycetes are nature’s medicine makers, producing over half of all known antibiotics and many other bioactive natural products....
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The Determination, Monitoring, Molecular Mechanisms and Formation of Biofilm in E. coli
Biofilms are cell assemblies embedded in an exopolysaccharide matrix formed by microorganisms of a single or many different species. This matrix in...
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Biofilm antimicrobial susceptibility through an experimental evolutionary lens
Experimental evolution experiments in which bacterial populations are repeatedly exposed to an antimicrobial treatment, and examination of the...
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Idiomarina rhizosphaerae sp. nov. isolated from rhizosphere soil of Kalidium cuspidatum, and reclassification of Idiomarina andamanensis as Pseudidiomarina andamanensis comb. nov., and Idiomarina mangrovi as Pseudidiomarina mangrovi comb. nov
A Gram-stain-negative, strictly aerobic, gliding motile, non-spore forming, rod-shaped indole-3-acetic acid producing bacterial strain, designated...
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Strategies to increase the robustness of microbial cell factories
Engineering microbial cell factories have achieved much progress in producing fuels, natural products and bulk chemicals. However, in industrial...
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Response to Phosphate Starvation and Osmotic Homeostasis
Phosphorus is one of the important nutrients for bacterial growth. Mostly, phosphorus is available in low concentrations in natural environment....
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Transcriptional Regulation of hmsB, A Temperature-Dependent Small RNA, by RovM in Yersinia pestis Biovar Microtus
HmsB, a temperature-dependent sRNA, promotes biofilm formation by Yersinia pestis , but whether its own expression is regulated by other regulators is...
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Polymyxins, the last-resort antibiotics: Mode of action, resistance emergence, and potential solutions
Infections caused by multi-drug resistant (MDR) bacterial pathogens are a leading cause of mortality and morbidity across the world. Indiscriminate...
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Phos-Tag Fluorescent Gel Staining for the Quantitative Detection of His- and Asp-Phosphorylated Proteins
We describe a standard protocol for phosphate-affinity fluorescent gel staining that uses a fluorophore-labeled dizinc(II) complex of a derivative of...