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Histone H2A deubiquitinase BAP1 is essential for endothelial cell differentiation from human pluripotent stem cells
Polycomb group proteins (PcGs) add repressive post translational histone modifications such as H2AK119ub1, and histone H2A deubiquitinases remove it....
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Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury
BackgroundVascular endothelial cells are pivotal in the pathophysiological progression following spinal cord injury (SCI). The UTX (Ubiquitously...
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Endothelial gene regulatory elements associated with cardiopharyngeal lineage differentiation
Endothelial cells (EC) differentiate from multiple sources, including the cardiopharyngeal mesoderm, which gives rise also to cardiac and...
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iPS Cell Differentiation into Brain Microvascular Endothelial Cells
The blood–brain barrier is a tissue structure that modulates the selective entry of molecules into the brain compartment. This barrier offers...
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Differentiation and Characterization of Human Pluripotent Stem Cell-Derived Cardiac Endothelial Cells for In Vitro Applications
Various protocols have been developed to generate endothelial cells for disease modeling, angiogenesis, vascular regeneration, and drug screening....
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Differentiation of mesenchymal stem cells into vascular endothelial cells in 3D culture: a mini review
Mesenchymal Stem Cells, mesodermal origin and multipotent stem cells, have ability to differentiate into vascular endothelial cells. The cells are...
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Endothelial and hematopoietic hPSCs differentiation via a hematoendothelial progenitor
BackgroundhPSC-derived endothelial and hematopoietic cells (ECs and HCs) are an interesting source of cells for tissue engineering. Despite their...
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Chemokine CCL2 Activates Hypoxia Response Factors Regulating Pluripotency and Directed Endothelial Differentiation of Human Pluripotent Stem Cells
AbstractHuman pluripotent stem cell (PSC) research is currently focused on selecting conditions and growth factors that better mimic preimplantation...
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Effect and mechanism of hypoxia on differentiation of porcine-induced pluripotent stem cells into vascular endothelial cells
Pigs are similar to humans in organ size and physiological function, and are considered as good models for studying cardiovascular diseases. The...
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PFKFB3-mediated glycometabolism reprogramming modulates endothelial differentiation and angiogenic capacity of placenta-derived mesenchymal stem cells
BackgroundMesenchymal stem cells (MSCs) have a great potential ability for endothelial differentiation, contributing to an effective means of...
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Single-Cell RNA-seq Analysis of a Human Embryonic Stem Cell to Endothelial Cell System Based on Transcription Factor Overexpression
BackgroundHuman embryonic stem cell (hESC)-derived endothelial cells (ECs) possess therapeutic potential in many diseases. Cytokine supplementation...
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Single cell RNA analysis uncovers the cell differentiation and functionalization for air breathing of frog lung
The evolution and development of vertebrate lungs have been widely studied due to their significance in terrestrial adaptation. Amphibians possess...
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Rab37 Promotes Endothelial Differentiation and Accelerates ADSC-Mediated Diabetic Wound Healing through Regulating Secretion of Hsp90α and TIMP1
Accumulating evidence indicates that adipose tissue-derived mesenchymal stem cells (ADSCs) are an effective treatment for diabetic refractory wounds....
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Flt1 produced by lung endothelial cells impairs ATII cell transdifferentiation and repair in pulmonary fibrosis
Pulmonary fibrosis is a devastating disease, in which fibrotic tissue progressively replaces lung alveolar structure, resulting in chronic...
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Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution
Bone marrow ablation is routinely performed before hematopoietic stem cell transplantation (HSCT). Hematopoietic stem and progenitor cells (HSPCs)...
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Angiogenesis Invasion Assay to Study Endothelial Cell Invasion and Sprouting Behavior
Angiogenesis is the formation of new blood vessels from the existing vasculature. It is a fundamental process in developmental biology but also a...
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High-efficient serum-free differentiation of endothelial cells from human iPS cells
IntroductionEndothelial cells (ECs) form the inner lining of all blood vessels of the body play important roles in vascular tone regulation, hormone...
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Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction
BackgroundResearch on human pluripotent stem cells (hPSCs) has shown tremendous progress in cell-based regenerative medicine. Corneal endothelial...
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The JNK-EGR1 signaling axis promotes TNF-α-induced endothelial differentiation of human mesenchymal stem cells via VEGFR2 expression
Mesenchymal stem cells (MSCs) can differentiate into endothelial cells; however, the mechanisms underlying this process in the tumor microenvironment...
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Bioprinting of human pluripotent stem cell derived corneal endothelial cells with hydrazone crosslinked hyaluronic acid bioink
BackgroundHuman corneal endothelial cells lack regenerative capacity through cell division in vivo . Consequently, in the case of trauma or...
