Search
Search Results
-
Endothelial gene regulatory elements associated with cardiopharyngeal lineage differentiation
Endothelial cells (EC) differentiate from multiple sources, including the cardiopharyngeal mesoderm, which gives rise also to cardiac and...
-
Extracellular vesicles from UTX-knockout endothelial cells boost neural stem cell differentiation in spinal cord injury
BackgroundVascular endothelial cells are pivotal in the pathophysiological progression following spinal cord injury (SCI). The UTX (Ubiquitously...
-
Differentiation of mesenchymal stem cells into vascular endothelial cells in 3D culture: a mini review
Mesenchymal Stem Cells, mesodermal origin and multipotent stem cells, have ability to differentiate into vascular endothelial cells. The cells are...
-
Effect and mechanism of hypoxia on differentiation of porcine-induced pluripotent stem cells into vascular endothelial cells
Pigs are similar to humans in organ size and physiological function, and are considered as good models for studying cardiovascular diseases. The...
-
iPS Cell Differentiation into Brain Microvascular Endothelial Cells
The blood–brain barrier is a tissue structure that modulates the selective entry of molecules into the brain compartment. This barrier offers...
-
Rab37 Promotes Endothelial Differentiation and Accelerates ADSC-Mediated Diabetic Wound Healing through Regulating Secretion of Hsp90α and TIMP1
Accumulating evidence indicates that adipose tissue-derived mesenchymal stem cells (ADSCs) are an effective treatment for diabetic refractory wounds....
-
Endothelial and hematopoietic hPSCs differentiation via a hematoendothelial progenitor
BackgroundhPSC-derived endothelial and hematopoietic cells (ECs and HCs) are an interesting source of cells for tissue engineering. Despite their...
-
PFKFB3-mediated glycometabolism reprogramming modulates endothelial differentiation and angiogenic capacity of placenta-derived mesenchymal stem cells
BackgroundMesenchymal stem cells (MSCs) have a great potential ability for endothelial differentiation, contributing to an effective means of...
-
Chemokine CCL2 Activates Hypoxia Response Factors Regulating Pluripotency and Directed Endothelial Differentiation of Human Pluripotent Stem Cells
AbstractHuman pluripotent stem cell (PSC) research is currently focused on selecting conditions and growth factors that better mimic preimplantation...
-
The JNK-EGR1 signaling axis promotes TNF-α-induced endothelial differentiation of human mesenchymal stem cells via VEGFR2 expression
Mesenchymal stem cells (MSCs) can differentiate into endothelial cells; however, the mechanisms underlying this process in the tumor microenvironment...
-
LncRNA MEG3 induces endothelial differentiation of mouse derived adipose-derived stem cells by targeting MiR-145-5p/KLF4
BackgroundThe present study aimed to investigate the mechanisms through which long non-coding RNA (lncRNA) maternally expressed 3 (MEG3) affected the...
-
High-efficient serum-free differentiation of endothelial cells from human iPS cells
IntroductionEndothelial cells (ECs) form the inner lining of all blood vessels of the body play important roles in vascular tone regulation, hormone...
-
Endothelial Robo4 suppresses endothelial-to-mesenchymal transition induced by irradiation and improves hematopoietic reconstitution
Bone marrow ablation is routinely performed before hematopoietic stem cell transplantation (HSCT). Hematopoietic stem and progenitor cells (HSPCs)...
-
Identification of a new way to induce differentiation of dermal fibroblasts into vascular endothelial cells
BackgroundHuman dermal fibroblasts (HDFs) have the potential to differentiate into vascular endothelial cells (VECs), but their differentiation rate...
-
Safety and efficacy of human ESC-derived corneal endothelial cells for corneal endothelial dysfunction
BackgroundResearch on human pluripotent stem cells (hPSCs) has shown tremendous progress in cell-based regenerative medicine. Corneal endothelial...
-
Differentiation and Characterization of Human Pluripotent Stem Cell-Derived Cardiac Endothelial Cells for In Vitro Applications
Various protocols have been developed to generate endothelial cells for disease modeling, angiogenesis, vascular regeneration, and drug screening....
-
Platelet factor 4 (PF4) induces cluster of differentiation 40 (CD40) expression in human aortic endothelial cells (HAECs) through the SIRT1/NF-κB/p65 signaling pathway
PF4 is a pro-atherosclerotic molecule. Endothelial CD40, upon binding to its ligand CD40L, induces endothelial cell (EC) activation, which is a vital...
-
Nestin and Notch3 collaboratively regulate angiogenesis, collagen production, and endothelial–mesenchymal transition in lung endothelial cells
BackgroundNestin, an intermediate filament protein, participates in various pathophysiological processes, including wound healing, angiogenesis,...
-
CD32 captures committed haemogenic endothelial cells during human embryonic development
During embryonic development, blood cells emerge from specialized endothelial cells, named haemogenic endothelial cells (HECs). As HECs are rare and...
-
Cardiac Microvascular Endothelial Cells and Pressure Overload-Induced Cardiac Fibrosis
Heart failure is one of the main causes of death worldwide. It is a consequence of ultimately maladaptive cardiac remodelling processes, i.e.,...