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Peptidoglycan endopeptidase MepM of uropathogenic Escherichia coli contributes to competitive fitness during urinary tract infections
BackgroundUrinary tract infections (UTIs) are common bacterial infections, primarily caused by uropathogenic Escherichia coli (UPEC), leading to...
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Asparaginyl endopeptidase protects against podocyte injury in diabetic nephropathy through cleaving cofilin-1
Podocyte injury and loss are critical events in diabetic nephropathy (DN); however, the underlying molecular mechanisms remain unclear. Here, we...
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Long-Term Social Isolation Reduces Expression of the BDNF Precursor and Prolyl Endopeptidase in the Rat Brain
AbstractEarly-life stress is a risk factor for the development of behavioral and cognitive disorders in humans and animals. Such stressful situations...
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Human small-intestinal gluten-degrading bacteria and its potential implication in celiac disease
Celiac disease (CeD) is an immune-mediated chronic disorder triggered by the ingestion of wheat gluten in genetically predisposed individuals. Gluten...
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Successive digestion of tilapia collagen by serine proteinase and proline specific endopeptidase to produce novel angiotensin I-converting enzyme inhibitory peptides
Serine proteinase, purified from the hepatopancreas of Pacific white shrimp ( Litopenaeus vannamei ), was used to hydrolyze acid solubilized collagen...
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Quantitative Analysis of Bacillus pumilus Serine Proteinases in Recombinant Bacillus Strains
AbstractA comparative study of the expression of B. pumilus extracellular serine proteinases (subtilisin-like proteinase and glutamyl endopeptidase)...
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Zygocin – a monomeric protein toxin secreted by virus-infected Zygosaccharomyces bailii
Zygocin, a protein toxin secreted by virus-infected strains of the osmotolerant spoilage yeast Zygosaccharomyces bailii kills a broad spectrum of...
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Aspergillus oryzae PrtR alters transcription of individual peptidase genes in response to the growth environment
AbstractAspergillus oryzae PrtR is an ortholog of the transcription factor PrtT, which positively regulates the transcription of extracellular...
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Enhancing proteolytic activity of Lysobacter enzymogenes using cold atmospheric plasma
Cold atmospheric plasma (CAP) is being used recently as a modern technique for microbial random mutagenesis. In the present study, CAP was used to...
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In Vitro Assays for the Bifunctional Acylpeptide Hydrolase (APEH) Enzyme from Antarctic Fish
The bifunctional enzyme acylpeptide hydrolase (APEH) is involved in important metabolic processes both as an exopeptidase and as an endopeptidase....
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GDF1 ameliorates cognitive impairment induced by hearing loss
Hearing loss is associated with an increased risk of Alzheimer disease (AD). However, the mechanisms of hearing loss promoting the onset of AD are...
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Recombinant Endopeptidases IdeS and IdeZ and Their Potential Application
AbstractEndopeptidases IdeS and IdeZ (streptococcal virulence factors that specifically cleave IgG heavy chains) are of particular interest because...
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Selenium Treatment Alleviates the Inhibition Caused by Nep-L Gene Knockdown in Silkworm (Bombyx mori)
Recent studies have emphasized the beneficial effects of 50 μM selenium (Se) on the growth and development of the silkworm, Bombyx mori ; however,...
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Neutral Endopeptidase (Neprilysin) in Therapy and Diagnostics: Yin and Yang
Neprilysin (NEP) is a zinc-dependent metalloproteinase that exists in organisms in both transmembrane and soluble forms. NEP substrates are involved...
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Antiparkinsonian Action of the Prolyl Endopeptidase Inhibitor in Mice
AbstractProlyl endopeptidase is involved in neurodegeneration, proliferation, neuroinflammation, and neuron differentiation. It has been observed...
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Evaluation of the Moonlighting Histone H3 Specific Protease (H3ase) Activity and the Dehydrogenase Activity of Glutamate Dehydrogenase (GDH)
The N-terminus of Histone H3 is proteolytically processed in aged chicken liver. A histone H3 N-terminus specific endopeptidase (named H3ase) has...
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Proximity Labelling Confirms the Involvement of Papain-Like Cysteine Proteases and Chaperones in Cyclotide Biosynthesis
Cyclotides are disulfide-rich insecticidal peptides from plants that harbour a cyclic cystine knot motif that imparts them with high stability. Like...
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Generalist endophyte Phomopsis liquidambaris colonization of Oryza sativa L. promotes plant growth under nitrogen starvation
Fungal endophytes establish symbiotic relationships with host plants, which results in a mutual growth benefit. However, little is known about the...
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A Novel Synonymous Variant of PHEX in a Patient with X-Linked Hypophosphatemia
X-linked dominant hypophosphatemia (XLH), the most common form of hereditary hypophosphatemic rickets/osteomalacia, is caused by loss-of-function...
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Function of PHEX mutations p.Glu145* and p.Trp749Arg in families with X-linked hypophosphatemic rickets by the negative regulation mechanism on FGF23 promoter transcription
X-linked hypophosphatemic rickets (XLH) is characterized by increased circulating fibroblast growth factor 23 (FGF23) concentration caused by PHEX ...
