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The transcription factor Sox7 modulates endocardiac cushion formation contributed to atrioventricular septal defect through Wnt4/Bmp2 signaling
Cardiac septum malformations account for the largest proportion in congenital heart defects. The transcription factor Sox7 has critical functions in...
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The roles and activation of endocardial Notch signaling in heart regeneration
As a highly conserved signaling pathway in metazoans, the Notch pathway plays important roles in embryonic development and tissue regeneration....
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Over-expression of Fgf8 in cardiac neural crest cells leads to persistent truncus arteriosus
During cardiogenesis, the outflow tract undergoes a complicated morphogenesis, including the re-alignment of the great blood vessels, and the...
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Generation and characterization of cardiac valve endothelial-like cells from human pluripotent stem cells
The cardiac valvular endothelial cells (VECs) are an ideal cell source that could be used for making the valve organoids. However, few studies have...
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Construction and comprehensive analysis of the competing endogenous RNA network in endometrial adenocarcinoma
BackgroundEndometrial carcinoma (EC) is one of the most common gynecological malignant tumors. In this study, we constructed gene co-expression...
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Developmental heart morphology in the Amazon turtle Podocnemis expansa (Testudines: Podocnemidae)
The study aims to describe the development of the heart in Podocnemis expansa during the incubation period and immediately after hatching. A total of...
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Role of Endocardium and Epicardium in Generation of Cardiomyocytes
Endocardial cells form the innermost layer of the heartHeart. EpicardiumEpicardium is the inner layer of the pericardium, the sac of fibrous tissue...
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Hypermethylation of NRG1 gene correlates with the presence of heart defects in Down’s syndrome
Congenital heart defects can decrease the quality of life and life expectancy in affected individuals, and constitute a major burden for the health...
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Mechanotransduction in Heart Development
The mechanical forces that the cells of an organism are subject to are an essential epigenetic factor impacting on their behavior. Heart development...
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Cardiovascular Diseases and Zinc
Zinc is structurally and functionally essential for more than 300 enzymes and 2000 transcription factors in human body. Intracellular labile zinc is...
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Current advances in human-induced pluripotent stem cell-based models and therapeutic approaches for congenital heart disease
Congenital heart disease (CHD) represents a significant risk factor with profound implications for neonatal survival rates and the overall well-being...
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Incidence, distribution, disease spectrum, and genetic deficits of congenital heart defects in China: implementation of prenatal ultrasound screening identified 18,171 affected fetuses from 2,452,249 pregnancies
BackgroundCongenital heart defects (CHDs) are the most common birth defects. Assessment of the incidence, distribution, disease spectrum, and genetic...
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Valvular Endothelial Cell Response to the Mechanical Environment—A Review
Heart valve leaflets are complex structures containing valve endothelial cells, interstitial cells, and extracellular matrix. Heart valve endothelial...
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Cardiac cell type-specific responses to injury and contributions to heart regeneration
Heart disease is the leading cause of mortality worldwide. Due to the limited proliferation rate of mature cardiomyocytes, adult mammalian hearts are...
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Mutation of LRP1 in cardiac neural crest cells causes congenital heart defects by perturbing outflow lengthening
The recent recovery of mutations in vesicular trafficking genes causing congenital heart disease (CHD) revealed an unexpected role for the endocytic...
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Genomic and physiological analyses of the zebrafish atrioventricular canal reveal molecular building blocks of the secondary pacemaker region
The atrioventricular canal (AVC) is the site where key structures responsible for functional division between heart regions are established, most...
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SOX9 in organogenesis: shared and unique transcriptional functions
The transcription factor SOX9 is essential for the development of multiple organs including bone, testis, heart, lung, pancreas, intestine and...
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Angiopoietin-like 2 is essential to aortic valve development in mice
Aortic valve (AoV) abnormalities during embryogenesis are a major risk for the development of aortic valve stenosis (AVS) and cardiac events later in...
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The versatility and paradox of BMP signaling in endothelial cell behaviors and blood vessel function
Blood vessels expand via sprouting angiogenesis, and this process involves numerous endothelial cell behaviors, such as collective migration,...
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Genome-wide association studies highlight novel risk loci for septal defects and left-sided congenital heart defects
BackgroundCongenital heart defects (CHD) are structural defects of the heart affecting approximately 1% of newborns. They exhibit low penetrance and...
