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Biochemical Studies to Understand Teratogenicity and Lethality Outcomes in Modified-FETAX
The frog embryo teratogenesis assay-Xenopus (FETAX) is a standardized test used to assess the toxic and teratogenic effects of xenobiotics. With this...
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The histone chaperone function of Daxx is dispensable for embryonic development
Daxx functions as a histone chaperone for the histone H3 variant, H3.3, and is essential for embryonic development. Daxx interacts with Atrx to form...
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Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities
Transcriptional co-regulators have been widely pursued as targets for disrupting oncogenic gene regulatory programs. However, many proteins in this...
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Acute expression of human APOBEC3B in mice results in RNA editing and lethality
BackgroundRNA editing has been described as promoting genetic heterogeneity, leading to the development of multiple disorders, including cancer. The...
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RNA-Mediated Regulation of Glycolysis in Embryonic Stem Cell Pluripotency and Differentiation
Purpose of ReviewThe maintenance and differentiation of embryonic stem cells are strictly coordinated with their metabolic status. As a core part of...
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RBM47 is a Critical Regulator of Mouse Embryonic Stem Cell Differentiation
RNA-binding proteins (RBPs) are pivotal for regulating gene expression as they are involved in each step of RNA metabolism. Several RBPs are...
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Sensitive-stage embryo irradiation affects embryonic neuroblasts and adult motor function
BackgroundCranial radiation therapy for treating childhood malignancies in the central nervous system or accidental radiation exposure may result in...
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Neonatal lethality of mouse A/J-7SM consomic strain is caused by an insertion mutation in the Dchs1 gene
Homosomic mice of the A/J-7 SM consomic mouse strain that introduced the entire chromosome 7 (Chr 7) of SM/J into the A/J strain exhibited neonatal...
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A CRISPR/Cas9 screen in embryonic stem cells reveals that Mdm2 regulates totipotency exit
During early embryonic development, the transition from totipotency to pluripotency is a fundamental and critical process for proper development....
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53BP1 loss rescues embryonic lethality but not genomic instability of BRCA1 total knockout mice
BRCA1 is critical for DNA double-strand break (DSB) repair by homologous recombination (HR). BRCA1 deficient mice are embryonic lethal. Previous...
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NSUN3-mediated mitochondrial tRNA 5-formylcytidine modification is essential for embryonic development and respiratory complexes in mice
In mammalian mitochondria, translation of the AUA codon is supported by 5-formylcytidine (f 5 C) modification in the mitochondrial methionine tRNA...
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tRNAGlu-derived fragments from embryonic extracellular vesicles modulate bovine embryo hatching
Transfer RNA-derived small RNAs (tsRNAs) have been shown to be involved in early embryo development and repression of endogenous retroelements in...
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SCAP contributes to embryonic angiogenesis by negatively regulating KISS-1 expression in mice
Sterol regulatory element-binding protein (SREBP) cleavage-activating protein (SCAP) is indispensable in organ development because it maintains...
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Polycomb repressive complexes 1 and 2 are each essential for maintenance of X inactivation in extra-embryonic lineages
In female mammals, one of the two X chromosomes becomes inactivated during development by X-chromosome inactivation (XCI). Although Polycomb...
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A class I histone deacetylase HDA-2 is essential for embryonic development and size regulation of fertilized eggs in Caenorhabditis elegans
BackgroundCaenorhabditis elegans encodes three class I histone deacetylases (HDACs), HDA-1, HDA-2, and HDA-3. Although HDA-1 is known to be involved...
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Rif1 Regulates Self-Renewal and Impedes Mesendodermal Differentiation of Mouse Embryonic Stem Cells
BackgroundRAP1 interacting factor 1 ( Rif1 ) is highly expressed in mice embryos and mouse embryonic stem cells (mESCs). It plays critical roles in...
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DNA methylation restricts coordinated germline and neural fates in embryonic stem cell differentiation
As embryonic stem cells (ESCs) transition from naive to primed pluripotency during early mammalian development, they acquire high DNA methylation...
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Lower expression of the equine maternally imprinted gene IGF2R is related to the slow proliferation of hinny embryonic fibroblast in vitro
BackgroundProliferation of embryonic fibroblasts under the same cell culture conditions, hinny embryonic fibroblasts (HiEFs) was slower than horse...
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The embryonic patterning gene Dbx1 governs the survival of the auditory midbrain via Tcf7l2-Ap2δ transcriptional cascade
At the top of the midbrain is the inferior colliculus (IC), which functions as the major hub for processing auditory information. Despite the...
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Genetic landscape of T cells identifies synthetic lethality for T-ALL
To capture the global gene network regulating the differentiation of immature T cells in an unbiased manner, large-scale forward genetic screens in...
